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GATA Binding Protein 2 (GATA2)

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NFE1B; Endothelial transcription factor GATA-2

GATA Binding Protein 2 (GATA2)
CCC A337
HGNC 4171
MGI 95662
PubMed 21892162
RGD 2664
UniProt P23769
Wiki GATA2

The GATA family of transcription factors, which contain zinc fingers in their DNA binding domain, have emerged as candidate regulators of gene expression in hematopoietic cells. GATA1 is essential for normal primitive and definitive erythropoiesis and is expressed at high levels in erythroid cells, mast cells, and megakaryocytes.

GATA2 is expressed in hematopoietic progenitors, including early erythroid cells, mast cells, and megakaryocytes, and also in nonhematopoietic embryonic stem cells. In chicken erythroid progenitors, forced expression of GATA2 promotes proliferation at the expense of differentiation. GATA3 expression is restricted to T-lymphoid cells and some nonhematopoietic cell types, including embryonic stem cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA337Hu01 Recombinant GATA Binding Protein 2 (GATA2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA337Hu01 Polyclonal Antibody to GATA Binding Protein 2 (GATA2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for GATA Binding Protein 2 (GATA2) CLIA Kit Customized Service Offer
n/a ELISA Kit for GATA Binding Protein 2 (GATA2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA337Mu01 Recombinant GATA Binding Protein 2 (GATA2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA337Mu01 Polyclonal Antibody to GATA Binding Protein 2 (GATA2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for GATA Binding Protein 2 (GATA2) CLIA Kit Customized Service Offer
n/a ELISA Kit for GATA Binding Protein 2 (GATA2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant GATA Binding Protein 2 (GATA2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to GATA Binding Protein 2 (GATA2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to GATA Binding Protein 2 (GATA2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for GATA Binding Protein 2 (GATA2) CLIA Kit Customized Service Offer
n/a ELISA Kit for GATA Binding Protein 2 (GATA2) ELISA Kit Customized Service Offer
  1. "Cloning of the GATA-binding protein that regulates endothelin-1 gene expression in endothelial cells."J. Biol. Chem. 266:16188-16192(1991) [PubMed] [Europe PMC] [Abstract]
  2. "Human transcription factor GATA-2. Evidence for regulation of preproendothelin-1 gene expression in endothelial cells."J. Biol. Chem. 267:1279-1285(1992) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Mutations in GATA2 are associated with the autosomal dominant and sporadic monocytopenia and mycobacterial infection (MonoMAC) syndrome." Blood 118:2653-2655(2011) [PubMed] [Europe PMC] [Abstract]
  7. "Mutations in GATA2 cause primary lymphedema associated with a predisposition to acute myeloid leukemia (Emberger syndrome)."Nat. Genet. 43:929-931(2011) [PubMed] [Europe PMC] [Abstract]
  8. "Heritable GATA2 mutations associated with familial myelodysplastic syndrome and acute myeloid leukemia." Nat. Genet. 43:1012-1017(2011) [PubMed] [Europe PMC] [Abstract]