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GATA Binding Protein 5 (GATA5)

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Transcription factor GATA-5

GATA Binding Protein 5 (GATA5)
CCC A342
HGNC 15802
MGI 109497
PubMed 21633169
RGD 1561365
UniProt Q9BWX5
Wiki GATA5

Transcription factor GATA-5 is is a transcription factor that contains two GATA-type zinc fingers. The encoded protein is known to bind to hepatocyte nuclear factor-1alpha (HNF-1alpha), and this interaction is essential for cooperative activation of the intestinal lactase-phlorizin hydrolase promoter. In other organisms, similar proteins may be involved in the establishment of cardiac smooth muscle cell diversity.

GATA5 Binds to the functionally important CEF-1 nuclear protein binding site in the cardiac-specific slow/cardiac troponin C transcriptional enhancer. May play an important role in the transcriptional program(s) that underlies smooth muscle cell diversity

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant GATA Binding Protein 5 (GATA5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to GATA Binding Protein 5 (GATA5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to GATA Binding Protein 5 (GATA5) Polyclonal Antibody Customized Service Offer
Assay Kits SEA342Hu ELISA Kit for GATA Binding Protein 5 (GATA5) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA342Mu01 Recombinant GATA Binding Protein 5 (GATA5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to GATA Binding Protein 5 (GATA5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to GATA Binding Protein 5 (GATA5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for GATA Binding Protein 5 (GATA5) CLIA Kit Customized Service Offer
n/a ELISA Kit for GATA Binding Protein 5 (GATA5) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA342Ra01 Recombinant GATA Binding Protein 5 (GATA5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA342Ra01 Polyclonal Antibody to GATA Binding Protein 5 (GATA5) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for GATA Binding Protein 5 (GATA5) CLIA Kit Customized Service Offer
n/a ELISA Kit for GATA Binding Protein 5 (GATA5) ELISA Kit Customized Service Offer
  1. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Novel GATA5 loss-of-function mutations underlie familial atrial fibrillation."Clinics (Sao Paulo) 67:1393-1399(2012) [PubMed] [Europe PMC] [Abstract]
  4. "Mutational spectrum of the GATA5 gene associated with familial atrial fibrillation."Int. J. Cardiol. 157:305-307(2012) [PubMed] [Europe PMC] [Abstract]
  5. "Rare non-synonymous variations in the transcriptional activation domains of GATA5 in bicuspid aortic valve disease."J. Mol. Cell. Cardiol. 53:277-281(2012) [PubMed] [Europe PMC] [Abstract]
  6. "GATA5 loss-of-function mutations underlie tetralogy of fallot."Int. J. Med. Sci. 10:34-42(2013) [PubMed] [Europe PMC] [Abstract]
  7. "A novel GATA5 loss-of-function mutation underlies lone atrial fibrillation."Int. J. Mol. Med. 31:43-50(2013) [PubMed] [Europe PMC] [Abstract]
  8. "GATA5 loss-of-function mutation responsible for the congenital ventriculoseptal defect."Pediatr. Cardiol. 34:504-511(2013) [PubMed] [Europe PMC] [Abstract]
  9. "GATA5 loss-of-function mutations associated with congenital bicuspid aortic valve."Int. J. Mol. Med. 33:1219-1226(2014) [PubMed] [Europe PMC] [Abstract]
  10. "Somatic GATA5 mutations in sporadic tetralogy of Fallot."Int. J. Mol. Med. 33:1227-1235(2014) [PubMed] [Europe PMC] [Abstract]
  11. "GATA5 loss-of-function mutation in familial dilated cardiomyopathy."Int. J. Mol. Med. 35:763-770(2015) [PubMed] [Europe PMC] [Abstract]