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Hypocretin Receptor 2 (HCRTR2)

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HCRTR-2; OX2R; OX2; Orexin Receptor 2

Hypocretin Receptor 2 (HCRTR2)
CCC A343
HGNC 4849
MGI 2680765
PubMed 21186399
RGD 2788
UniProt O43614
Wiki HCRTR2
is a G-protein coupled receptor expressed exclusively in the brain. It has 64% identity with OX1. OX2 binds both orexin A and orexin B neuropeptides. OX2 is involved in the central feedback mechanism that regulates feeding behaviour.
Hypothalamic orexin (hypocretin) neurons project to the key structures of the limbic system and orexin receptors, both orexin receptor type 1 (OXR1) and type 2 (OXR2), are expressed in most limbic regions.the up-regulation of OXR2 in the nucleus accumbens as an enduring molecular event that is correlated well with behavioral plasticity in response to chronic psychostimulant administration. This OXR2 up-regulation may reflect a key adaptation of limbic orexinergic transmission to chronic drug exposure and may thus be critical for the expression of motor plasticity.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Hypocretin Receptor 2 (HCRTR2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Hypocretin Receptor 2 (HCRTR2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Hypocretin Receptor 2 (HCRTR2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Hypocretin Receptor 2 (HCRTR2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Hypocretin Receptor 2 (HCRTR2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Hypocretin Receptor 2 (HCRTR2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Hypocretin Receptor 2 (HCRTR2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Hypocretin Receptor 2 (HCRTR2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Hypocretin Receptor 2 (HCRTR2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Hypocretin Receptor 2 (HCRTR2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Hypocretin Receptor 2 (HCRTR2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Hypocretin Receptor 2 (HCRTR2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Hypocretin Receptor 2 (HCRTR2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Hypocretin Receptor 2 (HCRTR2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Hypocretin Receptor 2 (HCRTR2) ELISA Kit Customized Service Offer
  1. "Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior." Cell 92:573-585(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Polymorphisms in hypocretin/orexin pathway genes and narcolepsy."Neurology 57:1896-1899(2001) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  4. "Hypocretin/orexin, sleep and narcolepsy."Bioessays 23:397-408(2001) [PubMed] [Europe PMC] [Abstract]
  5. "To eat or to sleep? Orexin in the regulation of feeding and wakefulness."Annu. Rev. Neurosci. 24:429-458(2001) [PubMed] [Europe PMC] [Abstract]