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Orexin (OX)

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HCRT; PPOX; Orexin A; Hypocretin 1; Orexin B; Hypocretin 2; Preproorexin; Hypocretin Neuropeptide Precursor

Orexin (OX)
CCC A346
HGNC 4847
MGI 1202306
PubMed 23398442
RGD 2786
UniProt O43612
Wiki Orexin
The polypeptides, named orexin A and orexin B, are derived from the same precursor (orexin) by proteolytic processing. The orexin-A peptide comprises gln33 to gly66, and the orexin-B peptide arg69 to met96, of the precursor protein. The predicted peptide for orexin A is identical in human, rat, mouse, and bovine. The predicted peptide for human orexin B shows only 2 amino acid differences when compared with the rodent sequence.
Preproorexin mRNA and immunoreactive orexin A are localized in neurons within and around the lateral and posterior hypothalamus in the adult rat brain. Northern blot analysis revealed that in the rat a 0.7-kb preproorexin mRNA species is expressed predominantly in the brain and in a small amount in testis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA346Hu01 Recombinant Orexin (OX) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA346Hu01 Polyclonal Antibody to Orexin (OX) WB; IHC; ICC; IP.
MAA346Hu21 Monoclonal Antibody to Orexin (OX) WB; IHC; ICC; IP.
Assay Kits CEA346Hu ELISA Kit for Orexin (OX) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA346Mu01 Recombinant Orexin (OX) Positive Control; Immunogen; SDS-PAGE; WB.
RPA346Mu02 Recombinant Orexin (OX) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA346Mu01 Polyclonal Antibody to Orexin (OX) WB; IHC; ICC; IP.
PAA346Mu02 Polyclonal Antibody to Orexin (OX) WB; IHC; ICC; IP.
Assay Kits CEA346Mu ELISA Kit for Orexin (OX) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA346Ra01 Recombinant Orexin (OX) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA346Ra01 Polyclonal Antibody to Orexin (OX) WB; IHC; ICC; IP.
Assay Kits CEA346Ra ELISA Kit for Orexin (OX) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior." Cell 92:573-585(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Structure and function of human prepro-orexin gene."J. Biol. Chem. 274:17771-17776(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Solution structure of a new hypothalamic neuropeptide, human hypocretin-2/orexin-B."Eur. J. Biochem. 266:831-839(1999) [PubMed] [Europe PMC] [Abstract]
  4. "Hypocretin/orexin, sleep and narcolepsy."Bioessays 23:397-408(2001) [PubMed] [Europe PMC] [Abstract]
  5. "To eat or to sleep? Orexin in the regulation of feeding and wakefulness."Annu. Rev. Neurosci. 24:429-458(2001) [PubMed] [Europe PMC] [Abstract]
  6. "Solution structure of human orexin-A: regulator of appetite and wakefulness."J. Biochem. Mol. Biol. 37:565-573(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Crystal structure of HLA-DQ0602 that protects against type 1 diabetes and confers strong susceptibility to narcolepsy."Proc. Natl. Acad. Sci. U.S.A. 101:1999-2004(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Orexin-A is composed of a highly conserved C-terminal and a specific, hydrophilic N-terminal region, revealing the structural basis of specific recognition by the orexin-1 receptor."J. Pept. Sci. 12:443-454(2006) [PubMed] [Europe PMC] [Abstract]
  9. "A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains." Nat. Med. 6:991-997(2000) [PubMed] [Europe PMC] [Abstract]