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Thyroglobulin (TG)

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AITD3; TGN

Thyroglobulin (TG)
CCC A355
HGNC 11764
MGI 98733
PubMed 15157556
RGD 3848
UniProt P01266
Wiki Thyroglobulin
Thyroglobulin (Tg) is a 660 kDa, dimeric protein produced by and used entirely within the thyroid gland. In earlier literature, Tg was referred to as "colloid".Thyroglobulin should not be confused with Thyroxine-binding globulin, a carrier protein responsible for carrying the thyroid hormones in the blood.Tg is used by the thyroid gland to produce the thyroid hormones thyroxine (T4) and triiodothyronine (T3). The active form of triiodothyronine, 3, 5, 3' triiodothyronine, is produced both within the thyroid gland and periphery by 5'-deiodinase (which has been referred to as tetraiodothyronine 5' deiodinase.)Thyroglobulin levels in the blood can be used as a tumor marker for certain kinds of thyroid cancer. Thyroglobulin levels in the blood can also be elevated in cases of Graves' disease.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA355Hu01 Recombinant Thyroglobulin (TG) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA355Hu01 Polyclonal Antibody to Thyroglobulin (TG) WB; IHC; ICC; IP.
MAA355Hu22 Monoclonal Antibody to Thyroglobulin (TG) WB; IHC; ICC; IP.
LAA355Hu71 Biotin-Linked Polyclonal Antibody to Thyroglobulin (TG) WB; IHC; ICC.
Assay Kits SEA355Hu ELISA Kit for Thyroglobulin (TG) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA355Hu CLIA Kit for Thyroglobulin (TG) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA355Mu01 Recombinant Thyroglobulin (TG) Positive Control; Immunogen; SDS-PAGE; WB.
RPA355Mu02 Recombinant Thyroglobulin (TG) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA355Mu01 Polyclonal Antibody to Thyroglobulin (TG) WB; IHC; ICC; IP.
PAA355Mu02 Polyclonal Antibody to Thyroglobulin (TG) WB; IHC; ICC; IP.
Assay Kits SEA355Mu ELISA Kit for Thyroglobulin (TG) Enzyme-linked immunosorbent assay for Antigen Detection.
AEA355Mu ELISA Kit for Anti-Thyroglobulin Antibody (Anti-TG) Enzyme-linked immunosorbent assay for Antibody Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA355Ra01 Recombinant Thyroglobulin (TG) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA355Ra01 Polyclonal Antibody to Thyroglobulin (TG) WB; IHC; ICC; IP.
MAA355Ra21 Monoclonal Antibody to Thyroglobulin (TG) WB; IHC; ICC; IP.
Assay Kits SEA355Ra ELISA Kit for Thyroglobulin (TG) Enzyme-linked immunosorbent assay for Antigen Detection.
AEA355Ra ELISA Kit for Anti-Thyroglobulin Antibody (Anti-TG) Enzyme-linked immunosorbent assay for Antibody Detection.

Organism species: Canis familiaris; Canine (Dog)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Thyroglobulin (TG) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Thyroglobulin (TG) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Thyroglobulin (TG) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Thyroglobulin (TG) CLIA Kit Customized Service Offer
n/a ELISA Kit for Thyroglobulin (TG) ELISA Kit Customized Service Offer

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NPA355Po01 Native Thyroglobulin (TG) Positive Control; Immunogen; SDS-PAGE; WB.
RPA355Po01 Recombinant Thyroglobulin (TG) Positive Control; Immunogen; SDS-PAGE; WB.
RPA355Po02 Recombinant Thyroglobulin (TG) Positive Control; Immunogen; SDS-PAGE; WB.
RPA355Po03 Recombinant Thyroglobulin (TG) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA355Po05 Polyclonal Antibody to Thyroglobulin (TG) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Thyroglobulin (TG) CLIA Kit Customized Service Offer
n/a ELISA Kit for Thyroglobulin (TG) ELISA Kit Customized Service Offer

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NPA355Bo01 Native Thyroglobulin (TG) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA355Bo05 Polyclonal Antibody to Thyroglobulin (TG) WB; IHC; ICC; IP.
PAA355Bo01 Polyclonal Antibody to Thyroglobulin (TG) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Thyroglobulin (TG) CLIA Kit Customized Service Offer
n/a ELISA Kit for Thyroglobulin (TG) ELISA Kit Customized Service Offer
  1. "Primary structure of human thyroglobulin deduced from the sequence of its 8448-base complementary DNA."Eur. J. Biochem. 165:491-498(1987) [PubMed] [Europe PMC] [Abstract]
  2. "The revised 8307 base pair coding sequence of human thyroglobulin transiently expressed in eukaryotic cells."Eur. J. Endocrinol. 136:508-515(1997) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence and analysis of human chromosome 8." Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
  4. "Sequence of the 5'-end quarter of the human-thyroglobulin messenger ribonucleic acid and of its deduced amino-acid sequence."Eur. J. Biochem. 147:53-58(1985) [PubMed] [Europe PMC] [Abstract]
  5. "Structural organization of the 5' region of the thyroglobulin gene. Evidence for intron loss and 'exonization' during evolution."J. Mol. Biol. 196:769-779(1987) [PubMed] [Europe PMC] [Abstract]
  6. "An unusually long poly(purine)-poly(pyrimidine) sequence is located upstream from the human thyroglobulin gene."Nucleic Acids Res. 13:5127-5144(1985) [PubMed] [Europe PMC] [Abstract]
  7. "Genomic organization of the 5' region of the human thyroglobulin gene."Eur. J. Endocrinol. 143:789-798(2000) [PubMed] [Europe PMC] [Abstract]
  8. "Genomic organization of the 3' region of the human thyroglobulin gene."Thyroid 9:903-912(1999) [PubMed] [Europe PMC] [Abstract]
  9. "Identification of a minor Tg mRNA transcript in RNA from normal and goitrous thyroids."Mol. Cell. Endocrinol. 84:R23-R26(1992) [PubMed] [Europe PMC] [Abstract]
  10. "Hormone synthesis in human thyroglobulin: possible cleavage of the polypeptide chain at the tyrosine donor site."FEBS Lett. 242:414-418(1989) [PubMed] [Europe PMC] [Abstract]
  11. "Preferential sites of proteolytic cleavage of bovine, human and rat thyroglobulin. The use of limited proteolysis to detect solvent-exposed regions of the primary structure."Eur. J. Biochem. 218:603-621(1993) [PubMed] [Europe PMC] [Abstract]
  12. "Characterization of hormonogenic sites in an N-terminal, cyanogen bromide fragment of human thyroglobulin."Arch. Biochem. Biophys. 320:96-105(1995) [PubMed] [Europe PMC] [Abstract]
  13. "Glycosylation in human thyroglobulin: location of the N-linked oligosaccharide units and comparison with bovine thyroglobulin."Arch. Biochem. Biophys. 327:61-70(1996) [PubMed] [Europe PMC] [Abstract]
  14. "Characterization of the type-1 repeat from thyroglobulin, a cysteine-rich module found in proteins from different families."Eur. J. Biochem. 240:125-133(1996) [PubMed] [Europe PMC] [Abstract]
  15. "Consensus sequences for early iodination and hormonogenesis in human thyroglobulin."J. Biol. Chem. 264:13541-13545(1989) [PubMed] [Europe PMC] [Abstract]
  16. "Sulfated tyrosines of thyroglobulin are involved in thyroid hormone synthesis."Biochem. Biophys. Res. Commun. 262:193-197(1999) [PubMed] [Europe PMC] [Abstract]
  17. "The hormonogenic tyrosine 5 of porcine thyroglobulin is sulfated."Biochem. Biophys. Res. Commun. 298:193-197(2002) [PubMed] [Europe PMC] [Abstract]
  18. "A single chondroitin 6-sulfate oligosaccharide unit at Ser-2730 of human thyroglobulin enhances hormone formation and limits proteolytic accessibility at the carboxyl terminus. Potential insights into thyroid homeostasis and autoimmunity."J. Biol. Chem. 281:22200-22211(2006) [PubMed] [Europe PMC] [Abstract]
  19. "Thyroglobulin gene point mutation associated with non-endemic simple goitre."Lancet 341:462-464(1993) [PubMed] [Europe PMC] [Abstract]
  20. "Two novel cysteine substitutions (C1263R and C1995S) of thyroglobulin cause a defect in intracellular transport of thyroglobulin in patients with congenital goiter and the variant type of adenomatous goiter."J. Clin. Endocrinol. Metab. 84:1438-1444(1999) [PubMed] [Europe PMC] [Abstract]
  21. "Amino acid substitutions in the thyroglobulin gene are associated with susceptibility to human and murine autoimmune thyroid disease."Proc. Natl. Acad. Sci. U.S.A. 100:15119-15124(2003) [PubMed] [Europe PMC] [Abstract]
  22. "A novel compound heterozygous mutation in the thyroglobulin gene resulting in congenital goitrous hypothyroidism with high serum triiodothyronine levels."J. Hum. Genet. 51:379-382(2006) [PubMed] [Europe PMC] [Abstract]
  23. "Congenital hypothyroidism with goitre caused by new mutations in the thyroglobulin gene."Clin. Endocrinol. (Oxf.) 67:351-357(2007) [PubMed] [Europe PMC] [Abstract]
  24. "Thyroglobulin gene mutations producing defective intracellular transport of thyroglobulin are associated with increased thyroidal type 2 iodothyronine deiodinase activity."J. Clin. Endocrinol. Metab. 92:1451-1457(2007) [PubMed] [Europe PMC] [Abstract]
  25. "The p.A2215D thyroglobulin gene mutation leads to deficient synthesis and secretion of the mutated protein and congenital hypothyroidism with wide phenotype variation."J. Clin. Endocrinol. Metab. 94:2938-2944(2009) [PubMed] [Europe PMC] [Abstract]