Fibrillin 3 (FBN3)
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More recently, fibrillin-3 was described and is believed to be located mainly in the brain. Along with the brain, fibrillin 1 has been localized in the gonads and ovaries of field mice.
Fibrillins, such as FBN3, are extracellular matrix macromolecules that perform architectural functions in most connective tissues. Fibrillins assemble into microfibrils that can be identified ultrastructurally as uniform, small-diameter fibrils.By sequencing clones obtained from a size-fractionated fetal brain cDNA library, Nagase et al. cloned FBN3, which they also called KIAA1776. The deduced 2,816-amino acid protein has an N-terminal signal sequence, numerous EGF-like repeats, and several 8-cysteine modules called TB domains. FBN3 shares more than 60% amino acid identity with FBN1, FBN2, and mouse Fbn2.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA381Hu01 | Recombinant Fibrillin 3 (FBN3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA381Hu01 | Polyclonal Antibody to Fibrillin 3 (FBN3) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Fibrillin 3 (FBN3) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Fibrillin 3 (FBN3) | ELISA Kit Customized Service Offer |
- "Differential expression of fibrillin-3 adds to microfibril variety in human and avian, but not rodent, connective tissues."Genomics 83:461-472(2004) [PubMed] [Europe PMC] [Abstract]
- "Three novel mutations of the fibrillin-1 gene and ten single nucleotide polymorphisms of the fibrillin-3 gene in Marfan syndrome patients."J. Hum. Genet. 49:404-407(2004) [PubMed] [Europe PMC] [Abstract]
- "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]