Early Growth Response Protein 1 (EGR1)
[Edit]Zif268; AT225; G0S30; KROX24; NGFI-A; TIS8; ZIF-268; ZNF225; NGFIA; TIS8; ZENK; Nerve Growth Factor-Induced Protein A; Transcription Factor ETR103; Zinc Finger Protein 225
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Zif268 is a mammalian transcription factor that is now officially known as Egr1.It was originally discovered in mouse. The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentiation and mitogenesis. Studies suggest this is a tumor suppressor gene.The DNA binding domain of Zif268 consists of three zinc finger domains of the Cys2His2 type. The amino acid structure of the Zif268 zinc finger domain is given in this table, using the single letter amino acid code. The fingers 1 to 3 are indicated by f1 - f3. The residues marked 'x' are not part of the zinc fingers, but rather serve to connect them all together.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA416Hu01 | Recombinant Early Growth Response Protein 1 (EGR1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA416Hu01 | Polyclonal Antibody to Early Growth Response Protein 1 (EGR1) | WB |
| MAA416Hu22 | Monoclonal Antibody to Early Growth Response Protein 1 (EGR1) | WB; IHC | |
| MAA416Hu21 | Monoclonal Antibody to Early Growth Response Protein 1 (EGR1) | WB; IHC | |
| Assay Kits | SEA416Hu | ELISA Kit for Early Growth Response Protein 1 (EGR1) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA416Mu01 | Recombinant Early Growth Response Protein 1 (EGR1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPA416Mu02 | Recombinant Early Growth Response Protein 1 (EGR1) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAA416Mu01 | Polyclonal Antibody to Early Growth Response Protein 1 (EGR1) | WB; IHC; ICC; IP. |
| PAA416Mu02 | Polyclonal Antibody to Early Growth Response Protein 1 (EGR1) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA416Mu | ELISA Kit for Early Growth Response Protein 1 (EGR1) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Early Growth Response Protein 1 (EGR1) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Early Growth Response Protein 1 (EGR1) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Early Growth Response Protein 1 (EGR1) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Early Growth Response Protein 1 (EGR1) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Early Growth Response Protein 1 (EGR1) | ELISA Kit Customized Service Offer |
- "cDNA sequence of the human cellular early growth response gene Egr-1."Nucleic Acids Res. 18:4283-4283(1990) [PubMed] [Europe PMC] [Abstract]
- "A gene coding for a zinc finger protein is induced during 12-O-tetradecanoylphorbol-13-acetate-stimulated HL-60 cell differentiation."J. Biochem. 111:272-277(1992) [PubMed] [Europe PMC] [Abstract]
- "Expression of a zinc finger gene in HTLV-I- and HTLV-II-transformed cells."Science 248:588-591(1990) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
- "Snail associates with EGR-1 and SP-1 to upregulate transcriptional activation of p15INK4b."FEBS J. 277:1202-1218(2010) [PubMed] [Europe PMC] [Abstract]