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Hepatocyte Nuclear Factor 4 Alpha (HNF4a)

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HNF4; HNF4a7; HNF4a8; HNF4a9; MODY; MODY1; NR2A1; NR2A21; TCF; TCF14; Nuclear Receptor Subfamily 2,Group A,Member 1; Transcription factor 14

Hepatocyte Nuclear Factor 4 Alpha (HNF4a)
CCC A418
HGNC 5024
MGI 109128
PubMed 21852396
RGD 2810
UniProt P41235
Wiki HNF4A

Hepatocyte nuclear factor 4 alpha is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. The extinction of many hepatic functions and their reexpression are correlated with the extinction and expression of hepatocyte nuclear factor-4 (HNF4).

This gene plays a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants.HNF4A is required for the PXR and CAR-mediated transcriptional activation of CYP3A4.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA418Hu01 Recombinant Hepatocyte Nuclear Factor 4 Alpha (HNF4a) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA418Hu01 Polyclonal Antibody to Hepatocyte Nuclear Factor 4 Alpha (HNF4a) WB; IHC; ICC; IP.
Assay Kits SEA418Hu ELISA Kit for Hepatocyte Nuclear Factor 4 Alpha (HNF4a) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Hepatocyte Nuclear Factor 4 Alpha (HNF4a) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Hepatocyte Nuclear Factor 4 Alpha (HNF4a) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Hepatocyte Nuclear Factor 4 Alpha (HNF4a) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Hepatocyte Nuclear Factor 4 Alpha (HNF4a) CLIA Kit Customized Service Offer
n/a ELISA Kit for Hepatocyte Nuclear Factor 4 Alpha (HNF4a) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Hepatocyte Nuclear Factor 4 Alpha (HNF4a) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Hepatocyte Nuclear Factor 4 Alpha (HNF4a) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Hepatocyte Nuclear Factor 4 Alpha (HNF4a) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Hepatocyte Nuclear Factor 4 Alpha (HNF4a) CLIA Kit Customized Service Offer
n/a ELISA Kit for Hepatocyte Nuclear Factor 4 Alpha (HNF4a) ELISA Kit Customized Service Offer
  1. "Isolation and characterization of a third isoform of human hepatocyte nuclear factor 4."Gene 173:275-280(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Human hepatocyte nuclear factor 4 isoforms are encoded by distinct and differentially expressed genes."Mol. Cell. Biol. 16:925-931(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1)."Nature 384:458-460(1996) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Cloning and sequencing of cDNAs encoding the human hepatocyte nuclear factor 4 indicate the presence of two isoforms in human liver."Gene 147:269-272(1994) [PubMed] [Europe PMC] [Abstract]
  7. "Recruitment of hepatocyte nuclear factor 4 into specific intranuclear compartments depends on tyrosine phosphorylation that affects its DNA-binding and transactivation potential."Proc. Natl. Acad. Sci. U.S.A. 92:9876-9880(1995) [PubMed] [Europe PMC] [Abstract]
  8. "AMP-activated protein kinase regulates HNF4alpha transcriptional activity by inhibiting dimer formation and decreasing protein stability."J. Biol. Chem. 278:27495-27501(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Multiple post-translational modifications in hepatocyte nuclear factor 4alpha."Biochem. Biophys. Res. Commun. 410:749-753(2011) [PubMed] [Europe PMC] [Abstract]
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  11. "Structural basis for HNF-4alpha activation by ligand and coactivator binding."J. Biol. Chem. 279:23311-23316(2004) [PubMed] [Europe PMC] [Abstract]
  12. "Organization and partial sequence of the hepatocyte nuclear factor-4-alpha/MODY1 gene and identification of a missense mutation, R127W, in a Japanese family with MODY."Diabetes 46:1652-1657(1997) [PubMed] [Europe PMC] [Abstract]
  13. "A missense mutation in the hepatocyte nuclear factor 4 alpha gene in a UK pedigree with maturity-onset diabetes of the young."Diabetologia 40:859-862(1997) [PubMed] [Europe PMC] [Abstract]
  14. "Studies of the genetic variability of the coding region of the hepatocyte nuclear factor-4alpha in Caucasians with maturity onset NIDDM."Diabetologia 40:980-983(1997) [PubMed] [Europe PMC] [Abstract]
  15. "A missense mutation in hepatocyte nuclear factor-4-alpha, resulting in a reduced transactivation activity, in human late-onset non-insulin-dependent diabetes mellitus."J. Clin. Invest. 101:521-526(1998) [PubMed] [Europe PMC] [Abstract]
  16. "Functional characterization of the MODY1 gene mutations HNF4(R127W), HNF4(V255M), and HNF4(E276Q)."Diabetes 48:1459-1465(1999) [PubMed] [Europe PMC] [Abstract]
  17. "Macrosomia and hyperinsulinaemic hypoglycaemia in patients with heterozygous mutations in the HNF4A gene."PLoS Med. 4:E118-E118(2007) [PubMed] [Europe PMC] [Abstract]
  18. "Novel presentations of congenital hyperinsulinism due to mutations in the MODY genes: HNF1A and HNF4A."J. Clin. Endocrinol. Metab. 97:E2026-2030(2012) [PubMed] [Europe PMC] [Abstract]
  19. "The HNF4A R76W mutation causes atypical dominant Fanconi syndrome in addition to a beta cell phenotype."J. Med. Genet. 51:165-169(2014) [PubMed] [Europe PMC] [Abstract]