≡

Growth Differentiation Factor 9 (GDF9)

[Edit]

Growth Differentiation Factor 9 (GDF9)
CCC A427
HGNC 4224
MGI 95692
PubMed 15515056
RGD 71038
UniProt O60383
Wiki GDF9

Growth factors synthesized by ovarian somatic cells directly affect oocyte growth and function. Growth differentiation factor-9 (GDF9) is expressed in oocytes and is thought to be required for ovarian folliculogenesis. GDF9 is a member of the transforming growth factor-beta (TGFβ) superfamily.
GDF9 plays an important role in the development of primary follicles in the ovary. It has a critical role in granulosa cell and theca cell growth, as well as in differentiation and maturation of the oocyte.GDF9 has been connected to differences in ovulation rate and in premature cessation of ovary function, therefore has a significant role in fertility. The cell surface receptor through which GDF9 generates a signal is the bone morphogenetic protein type II receptor (BMPR2).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA427Hu01 Recombinant Growth Differentiation Factor 9 (GDF9) Positive Control; Immunogen; SDS-PAGE; WB.
APA427Hu01 Active Growth Differentiation Factor 9 (GDF9) Cell culture; Activity Assays.
Antibodies PAA427Hu01 Polyclonal Antibody to Growth Differentiation Factor 9 (GDF9) WB; IHC; ICC; IP.
MAA427Hu22 Monoclonal Antibody to Growth Differentiation Factor 9 (GDF9) WB; IHC; ICC; IP.
Assay Kits SEA427Hu ELISA Kit for Growth Differentiation Factor 9 (GDF9) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA427Mu01 Recombinant Growth Differentiation Factor 9 (GDF9) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA427Mu01 Polyclonal Antibody to Growth Differentiation Factor 9 (GDF9) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Growth Differentiation Factor 9 (GDF9) CLIA Kit Customized Service Offer
n/a ELISA Kit for Growth Differentiation Factor 9 (GDF9) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA427Ra01 Recombinant Growth Differentiation Factor 9 (GDF9) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA427Ra01 Polyclonal Antibody to Growth Differentiation Factor 9 (GDF9) WB; IHC; ICC; IP.
MAA427Ra21 Monoclonal Antibody to Growth Differentiation Factor 9 (GDF9) WB; IHC; ICC; IP.
Assay Kits SEA427Ra ELISA Kit for Growth Differentiation Factor 9 (GDF9) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Human growth differentiation factor 9 (GDF-9) and its novel homolog GDF-9B are expressed in oocytes during early folliculogenesis."J. Clin. Endocrinol. Metab. 84:2744-2750(1999) [PubMed] [Europe PMC] [Abstract]
  4. "Growth differentiation factor-9 inhibits 3'5'-adenosine monophosphate-stimulated steroidogenesis in human granulosa and theca cells."J. Clin. Endocrinol. Metab. 87:2849-2856(2002) [PubMed] [Europe PMC] [Abstract]
  5. ErratumJ. Clin. Endocrinol. Metab. 87:4495-4495(2002)
  6. "Phosphorylation of bone morphogenetic protein-15 and growth and differentiation factor-9 plays a critical role in determining agonistic or antagonistic functions."Endocrinology 149:812-817(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Effects of growth differentiation factor 9 on cell cycle regulators and ERK42/44 in human granulosa cell proliferation."Am. J. Physiol. 296:E1344-E1353(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Golgi apparatus casein kinase phosphorylates bioactive Ser-6 of bone morphogenetic protein 15 and growth and differentiation factor 9."FEBS Lett. 584:801-805(2010) [PubMed] [Europe PMC] [Abstract]
  9. "Growth differentiation factor 9 reverses activin A suppression of steroidogenic acute regulatory protein expression and progesterone production in human granulosa-lutein cells."J. Clin. Endocrinol. Metab. 95:E172-E180(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Growth differentiating factor 9 (GDF9) and bone morphogenetic protein 15 both activate development of human primordial follicles in vitro, with seemingly more beneficial effects of GDF9."J. Clin. Endocrinol. Metab. 96:E1246-E1254(2011) [PubMed] [Europe PMC] [Abstract]
  11. "Growth differentiation factor 9 (GDF9) suppresses follistatin and follistatin-like 3 production in human granulosa-lutein cells."PLoS ONE 6:E22866-E22866(2011) [PubMed] [Europe PMC] [Abstract]
  12. "The ratio of growth differentiation factor 9: bone morphogenetic protein 15 mRNA expression is tightly co-regulated and differs between species over a wide range of ovulation rates."Mol. Cell. Endocrinol. 348:339-343(2012) [PubMed] [Europe PMC] [Abstract]
  13. "Mutational screening of the coding region of growth differentiation factor 9 gene in Indian women with ovarian failure."Menopause 12:749-754(2005) [PubMed] [Europe PMC] [Abstract]
  14. "Mutations and sequence variants in GDF9 and BMP15 in patients with premature ovarian failure."Eur. J. Endocrinol. 154:739-744(2006) [PubMed] [Europe PMC] [Abstract]
  15. "Novel variants in growth differentiation factor 9 in mothers of dizygotic twins."J. Clin. Endocrinol. Metab. 91:4713-4716(2006) [PubMed] [Europe PMC] [Abstract]
  16. "Growth differentiating factor-9 mutations may be associated with premature ovarian failure."Fertil. Steril. 87:143-146(2007) [PubMed] [Europe PMC] [Abstract]
  17. "Analyses of GDF9 mutation in 100 Chinese women with premature ovarian failure."Fertil. Steril. 88:1474-1476(2007) [PubMed] [Europe PMC] [Abstract]
  18. "Analyses of growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) mutation in Chinese women with premature ovarian failure."Clin. Endocrinol. (Oxf.) 72:135-136(2010) [PubMed] [Europe PMC] [Abstract]