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Protein Kinase C Delta (PKCd)

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PKC-D; MAY1; PRKCD; SDK1; NPKC-Delta; Tyrosine-protein kinase PRKCD; Sphingosine-dependent protein kinase-1

Protein Kinase C Delta (PKCd)
CCC A433
HGNC 9399
MGI 97598
PubMed 21687362
RGD 67383
UniProt Q05655
Wiki PRKCD

  • The genes encoding the protein kinase C enzymes are widely distributed, e.g., PRKCA on chromosome 17, PRKCB1 on 16, and PRKCG on 19. Although the sequence homology among the PRKC family of genes is extensive, the pattern of expression varies among tissues. For example, the delta polypeptide appears to be the major isoform expressed in mouse hematopoietic cells. Mischak et al. (1991) isolated and characterized the mouse Prkcd gene.Aris et al. (1993) found that PKC-delta underwent calcium-independent autophosphorylation in the presence of phosphatidylserine and diacylglycerol. Diacylglycerol was an absolute requirement for PKC-delta activation. This and other cofactor and substrate requirements distinguished human PKC-delta from its mouse homolog.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA433Hu01 Recombinant Protein Kinase C Delta (PKCd) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA433Hu01 Polyclonal Antibody to Protein Kinase C Delta (PKCd) WB; IHC; ICC; IP.
LAA433Hu71 Biotin-Linked Polyclonal Antibody to Protein Kinase C Delta (PKCd) WB; IHC; ICC.
MAA433Hu21 Monoclonal Antibody to Protein Kinase C Delta (PKCd) WB; IHC; ICC; IP.
Assay Kits SEA433Hu ELISA Kit for Protein Kinase C Delta (PKCd) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA433Mu01 Recombinant Protein Kinase C Delta (PKCd) Positive Control; Immunogen; SDS-PAGE; WB.
RPA433Mu02 Recombinant Protein Kinase C Delta (PKCd) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA433Mu01 Polyclonal Antibody to Protein Kinase C Delta (PKCd) WB; IHC; ICC; IP.
PAA433Mu02 Polyclonal Antibody to Protein Kinase C Delta (PKCd) WB; IHC; ICC; IP.
Assay Kits SEA433Mu ELISA Kit for Protein Kinase C Delta (PKCd) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA433Ra01 Recombinant Protein Kinase C Delta (PKCd) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA433Ra01 Polyclonal Antibody to Protein Kinase C Delta (PKCd) WB; IHC; ICC; IP.
MAA433Ra21 Monoclonal Antibody to Protein Kinase C Delta (PKCd) WB; IHC; ICC; IP.
Assay Kits SEA433Ra ELISA Kit for Protein Kinase C Delta (PKCd) Enzyme-linked immunosorbent assay for Antigen Detection.
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  11. "Protein kinase Cdelta is responsible for constitutive and DNA damage-induced phosphorylation of Rad9."EMBO J. 22:1431-1441(2003) [PubMed] [Europe PMC] [Abstract]
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  19. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  20. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  21. "Lyn, PKC-delta, SHIP-1 interactions regulate GPVI-mediated platelet-dense granule secretion."Blood 114:3056-3063(2009) [PubMed] [Europe PMC] [Abstract]
  22. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  23. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  24. "Regulation of TNF-induced oxygen radical production in human neutrophils: role of delta-PKC."J. Leukoc. Biol. 87:153-164(2010) [PubMed] [Europe PMC] [Abstract]
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  27. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  28. "Two faces of protein kinase Cdelta: the contrasting roles of PKCdelta in cell survival and cell death."ScientificWorldJournal 10:2272-2284(2010) [PubMed] [Europe PMC] [Abstract]
  29. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  30. "PKC-delta and PKC-epsilon: Foes of the same family or strangers?"J. Mol. Cell. Cardiol. 51:665-673(2011) [PubMed] [Europe PMC] [Abstract]
  31. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  32. "Protein kinase cdelta in apoptosis: a brief overview."Arch. Immunol. Ther. Exp. 60:361-372(2012) [PubMed] [Europe PMC] [Abstract]
  33. "B-cell deficiency and severe autoimmunity caused by deficiency of protein kinase C delta."Blood 121:3112-3116(2013) [PubMed] [Europe PMC] [Abstract]
  34. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
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  36. "Solution structure of the first phorbol esters/diacylglycerol binding domain of human protein kinase C, delta."Submitted (APR-2008) to the PDB data bank