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5T4

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5T4-AG; M6P1; WAIF1; 5T4 oncofetal trophoblast glycoprotein; Wnt-activated inhibitory factor 1; Trophoblast Glycoprotein

5T4
CCC A434
HGNC 12004
MGI 1341264
PubMed 20980737
RGD 621453
UniProt Q13641
Wiki TPBG

5T4 is an antigen expressed in a number of carcinomas. It is an N-glycosylated transmembrane 72 kDa glycoprotein containing seven leucine-rich repeat regions. 5T4 is often referred to as an oncofetal antigen due to its expression in foetal trophoblast (where it was first discovered) or trophoblast glycoprotein (TPBG).

5T4 is found in tumors including the colorectal, ovarian, and gastric. Its expression is used as a prognostic aid in these cases. It has very limited expression in normal tissue but is widespread in malignant tumors throughout their development. Its confined expression appears to give 5T4 the potential to be useful in cancer immunotherapy. 5T4 is also the target of the cancer vaccine TroVax which is used in the treatment of colorectal cancer.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA434Hu01 Recombinant 5T4 Positive Control; Immunogen; SDS-PAGE; WB.
APA434Hu61 Active 5T4 Cell culture; Activity Assays.
Antibodies PAA434Hu01 Polyclonal Antibody to 5T4 WB,IHC
Assay Kits n/a CLIA Kit for 5T4 CLIA Kit Customized Service Offer
n/a ELISA Kit for 5T4 ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA434Mu01 Recombinant 5T4 Positive Control; Immunogen; SDS-PAGE; WB.
EPA434Mu61 Eukaryotic 5T4 Positive Control; Immunogen; SDS-PAGE; WB.
APA434Mu61 Active 5T4 Cell culture; Activity Assays.
Antibodies PAA434Mu01 Polyclonal Antibody to 5T4 WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for 5T4 CLIA Kit Customized Service Offer
n/a ELISA Kit for 5T4 ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant 5T4 Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to 5T4 Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to 5T4 Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for 5T4 CLIA Kit Customized Service Offer
n/a ELISA Kit for 5T4 ELISA Kit Customized Service Offer
  1. "Isolation of a cDNA encoding 5T4 oncofetal trophoblast glycoprotein: an antigen associated with metastasis contains leucine rich repeats."J. Biol. Chem. 269:9319-9324(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries." DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Attenuated recombinant vaccinia virus expressing oncofetal antigen (tumor-associated antigen) 5T4 induces active therapy of established tumors."Mol. Cancer Ther. 1:1129-1137(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Waif1/5T4 inhibits Wnt/beta-catenin signaling and activates noncanonical Wnt pathways by modifying LRP6 subcellular localization."Dev. Cell 21:1129-1143(2011) [PubMed] [Europe PMC] [Abstract]
  9. "Structural insights into the inhibition of Wnt signaling by cancer antigen 5T4/Wnt-activated inhibitory factor 1."Structure 22:612-620(2014) [PubMed] [Europe PMC] [Abstract]