Prohibitin (PHB)
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Prohibitin is a protein which in humans is encoded by the PHB gene. The Phb gene has also been described in animals, fungi, plants and unicellular eukaryotes. Prohibitins are divided in two classes, termed Type-I and Type-II prohibitins, based on their similarity to yeast PHB1 or PHB2, respectively.
Each organism has at least one copy of each type of prohibitin gene.Prohibitins are evolutionarily conserved genes that are ubiquitously expressed. The human prohibitin gene, located on the BRCA1 chromosome region 17q21, was originally thought to be a negative regulator of cell proliferation and a tumor suppressor. This anti-proliferative activity was later attributed to the 3' UTR of the PHB gene, and not to the actual protein.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA442Hu01 | Recombinant Prohibitin (PHB) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPA442Hu02 | Recombinant Prohibitin (PHB) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAA442Hu01 | Polyclonal Antibody to Prohibitin (PHB) | WB,IHC |
| MAA442Hu22 | Monoclonal Antibody to Prohibitin (PHB) | WB; IHC; ICC; IP. | |
| LAA442Hu71 | Biotin-Linked Polyclonal Antibody to Prohibitin (PHB) | WB; IHC; ICC. | |
| PAA442Hu02 | Polyclonal Antibody to Prohibitin (PHB) | WB; IHC | |
| Assay Kits | SEA442Hu | ELISA Kit for Prohibitin (PHB) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA442Mu01 | Recombinant Prohibitin (PHB) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPA442Mu02 | Recombinant Prohibitin (PHB) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAA442Mu01 | Polyclonal Antibody to Prohibitin (PHB) | WB; IHC; ICC; IP. |
| PAA442Mu02 | Polyclonal Antibody to Prohibitin (PHB) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA442Mu | ELISA Kit for Prohibitin (PHB) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA442Ra01 | Recombinant Prohibitin (PHB) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA442Ra01 | Polyclonal Antibody to Prohibitin (PHB) | WB; IHC; ICC; IP. |
| MAA442Ra21 | Monoclonal Antibody to Prohibitin (PHB) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA442Ra | ELISA Kit for Prohibitin (PHB) | Enzyme-linked immunosorbent assay for Antigen Detection. |
- "The human prohibitin gene located on chromosome 17q21 is mutated in sporadic breast cancer."Cancer Res. 52:1643-1646(1992) [PubMed] [Europe PMC] [Abstract]
- "The human prohibitin (PHB) gene family and its somatic mutations in human tumors."Genomics 17:762-764(1993) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]