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Kallikrein 4 (KLK4)

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ARM1; EMSP1; KLK-L1; PRSS17; PSTS; Enamel Matrix,Prostate; Kallikrein-Related Peptidase 4; Enamel matrix serine proteinase 1; Serine protease 17; Kallikrein-like protein 1

Kallikrein 4 (KLK4)
CCC A450
HGNC 6365
MGI 1861379
PubMed 16800736
RGD 1303228
UniProt Q9Y5K2
Wiki KLK4

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19.

KLK4 was predominantly expressed in nuclei of basal cells in the prostate epithelium, in keeping with its distribution in prostate cancer cells in vitro. Adenovirus-mediated KLK4 expression dramatically induced proliferation of prostate cancer cells, at least in part, through significant alterations in cell cycle regulatory gene expression. Consistent with this data, small interfering RNA-mediated knockdown of endogenous KLK4 in LNCaP prostate cancer cells inhibited cell growth.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA450Hu01 Recombinant Kallikrein 4 (KLK4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA450Hu01 Polyclonal Antibody to Kallikrein 4 (KLK4) WB; IHC; ICC; IP.
MAA450Hu22 Monoclonal Antibody to Kallikrein 4 (KLK4) WB; IHC; ICC; IP.
Assay Kits SEA450Hu ELISA Kit for Kallikrein 4 (KLK4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA450Mu01 Recombinant Kallikrein 4 (KLK4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA450Mu01 Polyclonal Antibody to Kallikrein 4 (KLK4) WB; IHC; ICC; IP.
LAA450Mu81 FITC-Linked Polyclonal Antibody to Kallikrein 4 (KLK4) WB; IHC; ICC; IF.
LAA450Mu71 Biotin-Linked Polyclonal Antibody to Kallikrein 4 (KLK4) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Kallikrein 4 (KLK4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Kallikrein 4 (KLK4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA450Ra01 Recombinant Kallikrein 4 (KLK4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA450Ra01 Polyclonal Antibody to Kallikrein 4 (KLK4) WB; IHC; ICC; IP.
MAA450Ra21 Monoclonal Antibody to Kallikrein 4 (KLK4) WB; IHC; ICC; IP.
Assay Kits SEA450Ra ELISA Kit for Kallikrein 4 (KLK4) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Molecular cloning and characterization of prostase, an androgen-regulated serine protease with prostate-restricted expression."Proc. Natl. Acad. Sci. U.S.A. 96:3114-3119(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Prostase/KLK-L1 is a new member of the human kallikrein gene family, is expressed in prostate and breast tissues, and is hormonally regulated."Cancer Res. 59:4252-4256(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Localization of a new prostate-specific antigen-related serine protease gene, KLK4, is evidence for an expanded human kallikrein gene family cluster on chromosome 19q13.3-13.4."J. Biol. Chem. 274:23210-23214(1999) [PubMed] [Europe PMC] [Abstract]
  4. "Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region."Gene 257:119-130(2000) [PubMed] [Europe PMC] [Abstract]
  5. "Characterization of the mouse and human PRSS17 genes, their relationship to other serine proteases, and the expression of PRSS17 in developing mouse incisors."Gene 251:1-8(2000) [PubMed] [Europe PMC] [Abstract]
  6. "Distinctly different gene structure of KLK4/KLK-L1/prostase/ARM1 compared with other members of the kallikrein family: intracellular localization, alternative cDNA forms, and Regulation by multiple hormones."DNA Cell Biol. 20:435-445(2001) [PubMed] [Europe PMC] [Abstract]
  7. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Cloning and characterization of a cDNA encoding human EMSP1."(In) Goldberg M. (eds.);Chemistry and biology of mineralized tissues, pp.1-1, American Academy of Orthopaedic Surgeons, Vittel (2000)
  10. "Crystal structures of human tissue kallikrein 4: activity modulation by a specific zinc binding site."J. Mol. Biol. 362:1094-1107(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Mutation in kallikrein 4 causes autosomal recessive hypomaturation amelogenesis imperfecta."J. Med. Genet. 41:545-549(2004) [PubMed] [Europe PMC] [Abstract]