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Protein Kinase C Theta (PKCq)

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PRKC-Q; PRKCQ; PRKCT; NPKC-Theta

Protein Kinase C Theta (PKCq)
CCC A494
HGNC 9410
MGI 97601
PubMed 9021158
RGD 620968
UniProt Q04759
Wiki PRKCQ

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA494Hu01 Recombinant Protein Kinase C Theta (PKCq) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA494Hu01 Polyclonal Antibody to Protein Kinase C Theta (PKCq) WB
Assay Kits n/a CLIA Kit for Protein Kinase C Theta (PKCq) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Kinase C Theta (PKCq) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Kinase C Theta (PKCq) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Kinase C Theta (PKCq) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Kinase C Theta (PKCq) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Kinase C Theta (PKCq) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Kinase C Theta (PKCq) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Kinase C Theta (PKCq) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Kinase C Theta (PKCq) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Kinase C Theta (PKCq) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Kinase C Theta (PKCq) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Kinase C Theta (PKCq) ELISA Kit Customized Service Offer
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  2. ErratumJ. Biol. Chem. 269:31322-31322(1994) [PubMed] [Europe PMC] [Abstract]
  3. "Molecular cloning and characterization of PKC theta, a novel member of the protein kinase C (PKC) gene family expressed predominantly in hematopoietic cells."J. Biol. Chem. 268:4997-5004(1993) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Protein kinase C-theta isoenzyme selective stimulation of the transcription factor complex AP-1 in T lymphocytes."Mol. Cell. Biol. 16:1842-1850(1996) [PubMed] [Europe PMC] [Abstract]
  8. "Inhibition of the c-Jun N-terminal kinase/AP-1 and NF-kappaB pathways by PICOT, a novel protein kinase C-interacting protein with a thioredoxin homology domain."J. Biol. Chem. 275:1902-1909(2000) [PubMed] [Europe PMC] [Abstract]
  9. "Regulation of protein kinase Ctheta function during T cell activation by Lck-mediated tyrosine phosphorylation."J. Biol. Chem. 275:3603-3609(2000) [PubMed] [Europe PMC] [Abstract]
  10. "Protein kinase C-theta mediates a selective T cell survival signal via phosphorylation of BAD."J. Immunol. 166:5955-5963(2001) [PubMed] [Europe PMC] [Abstract]
  11. "Phosphorylation of the protein kinase C-theta activation loop and hydrophobic motif regulates its kinase activity, but only activation loop phosphorylation is critical to in vivo nuclear-factor-kappaB induction."Biochem. J. 361:255-265(2002) [PubMed] [Europe PMC] [Abstract]
  12. "SPAK kinase is a substrate and target of PKCtheta in T-cell receptor-induced AP-1 activation pathway."EMBO J. 23:1112-1122(2004) [PubMed] [Europe PMC] [Abstract]
  13. "Protein kinase C Theta inhibits insulin signaling by phosphorylating IRS1 at Ser(1101)."J. Biol. Chem. 279:45304-45307(2004) [PubMed] [Europe PMC] [Abstract]
  14. "Nucleotide exchange factor ECT2 interacts with the polarity protein complex Par6/Par3/protein kinase Czeta (PKCzeta) and regulates PKCzeta activity."Mol. Cell. Biol. 24:6665-6675(2004) [PubMed] [Europe PMC] [Abstract]
  15. "Critical role of novel Thr-219 autophosphorylation for the cellular function of PKCtheta in T lymphocytes."EMBO J. 24:3869-3880(2005) [PubMed] [Europe PMC] [Abstract]
  16. "Phosphorylation of the CARMA1 linker controls NF-kappaB activation."Immunity 23:561-574(2005) [PubMed] [Europe PMC] [Abstract]
  17. "Protein kinase C-theta-mediated signals enhance CD4+ T cell survival by up-regulating Bcl-xL."J. Immunol. 176:6709-6716(2006) [PubMed] [Europe PMC] [Abstract]
  18. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  19. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  20. "PKC-theta modulates the strength of T cell responses by targeting Cbl-b for ubiquitination and degradation."Sci. Signal. 2:RA30-RA30(2009) [PubMed] [Europe PMC] [Abstract]
  21. "Protein kinase C(theta) in T cell activation."Annu. Rev. Immunol. 20:761-794(2002) [PubMed] [Europe PMC] [Abstract]
  22. "Protein kinase C-theta (PKC theta): a key enzyme in T cell life and death."J. Biochem. 132:841-846(2002) [PubMed] [Europe PMC] [Abstract]
  23. "Protein kinase C and beyond."Nat. Immunol. 5:785-790(2004) [PubMed] [Europe PMC] [Abstract]
  24. "Selective function of PKC-theta in T cells."Cell. Mol. Immunol. 3:263-270(2006) [PubMed] [Europe PMC] [Abstract]
  25. "Protein kinase C theta (PKCtheta): a key player in T cell life and death."Pharmacol. Res. 55:537-544(2007) [PubMed] [Europe PMC] [Abstract]
  26. "T-cell fate and function: PKC-theta and beyond."Trends Immunol. 29:179-185(2008) [PubMed] [Europe PMC] [Abstract]
  27. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  28. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  29. "Protein kinase C-theta in platelet activation."FEBS Lett. 585:3208-3215(2011) [PubMed] [Europe PMC] [Abstract]
  30. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  31. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  32. "Catalytic domain crystal structure of protein kinase C-theta (PKCtheta)."J. Biol. Chem. 279:50401-50409(2004) [PubMed] [Europe PMC] [Abstract]
  33. "The crystal structure of the kinase domain of the protein kinase C theta in complex with Nvp-Xaa228."Submitted (JAN-2007) to the PDB data bank
  34. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]