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Interleukin Enhancer Binding Factor 3 (ILF3)

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DRBF; DRBP76; MMP4; MPHOSPH4; MPP4; NFAT; NF-AT-90; NF90; NFAR1; TCP80; Nuclear Factor Of Activated T-Cells; M-Phase Phosphoprotein 4

Interleukin Enhancer Binding Factor 3 (ILF3)
CCC A504
HGNC 6038
MGI 1339973
PubMed 9620363
RGD 619734
UniProt Q12906
Wiki ILF3

Nuclear factor of activated T-cells (NFAT) is a transcription factor required for T-cell expression of interleukin 2. NFAT binds to a sequence in the IL2 enhancer known as the antigen receptor response element 2. In addition, NFAT can bind RNA and is an essential component for encapsidation and protein priming of hepatitis B viral polymerase. NFAT is a heterodimer of 45 kDa and 90 kDa proteins, the larger of which is the product of this gene. The encoded protein, which is primarily localized to ribosomes, probably regulates transcription at the level of mRNA elongation. At least three transcript variants encoding three different isoforms have been found for this gene.Viranaicken et al. (2006) identified an additional alternatively spliced exon within intron 2 of the mouse and human ILF3 genes, increasing the total number of exons to 22.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA504Hu01 Recombinant Interleukin Enhancer Binding Factor 3 (ILF3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA504Hu01 Polyclonal Antibody to Interleukin Enhancer Binding Factor 3 (ILF3) WB; IHC; ICC; IP.
Assay Kits SEA504Hu ELISA Kit for Interleukin Enhancer Binding Factor 3 (ILF3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Interleukin Enhancer Binding Factor 3 (ILF3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Interleukin Enhancer Binding Factor 3 (ILF3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Interleukin Enhancer Binding Factor 3 (ILF3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Interleukin Enhancer Binding Factor 3 (ILF3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interleukin Enhancer Binding Factor 3 (ILF3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Interleukin Enhancer Binding Factor 3 (ILF3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Interleukin Enhancer Binding Factor 3 (ILF3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Interleukin Enhancer Binding Factor 3 (ILF3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Interleukin Enhancer Binding Factor 3 (ILF3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interleukin Enhancer Binding Factor 3 (ILF3) ELISA Kit Customized Service Offer

Organism species: Danio rerio (Zebrafish)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA504Fi01 Recombinant Interleukin Enhancer Binding Factor 3 (ILF3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Interleukin Enhancer Binding Factor 3 (ILF3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Interleukin Enhancer Binding Factor 3 (ILF3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Interleukin Enhancer Binding Factor 3 (ILF3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interleukin Enhancer Binding Factor 3 (ILF3) ELISA Kit Customized Service Offer
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  5. "Characterization of two evolutionarily conserved, alternatively spliced nuclear phosphoproteins, NFAR-1 and -2, that function in mRNA processing and interact with the double-stranded RNA-dependent protein kinase, PKR."J. Biol. Chem. 276:32300-32312(2001) [PubMed] [Europe PMC] [Abstract]
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  12. "Autoantibodies define a family of proteins with conserved double-stranded RNA-binding domains as well as DNA binding activity."J. Biol. Chem. 274:34598-34604(1999) [PubMed] [Europe PMC] [Abstract]
  13. "Protein-arginine methyltransferase I, the predominant protein-arginine methyltransferase in cells, interacts with and is regulated by interleukin enhancer-binding factor 3."J. Biol. Chem. 275:19866-19876(2000) [PubMed] [Europe PMC] [Abstract]
  14. "Exportin-5, a novel karyopherin, mediates nuclear export of double-stranded RNA binding proteins."J. Cell Biol. 156:53-64(2002) [PubMed] [Europe PMC] [Abstract]
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  16. "The RNA binding protein nuclear factor 90 functions as both a positive and negative regulator of gene expression in mammalian cells."Mol. Cell. Biol. 22:343-356(2002) [PubMed] [Europe PMC] [Abstract]
  17. "Minihelix-containing RNAs mediate exportin-5-dependent nuclear export of the double-stranded RNA-binding protein ILF3."J. Biol. Chem. 279:884-891(2004) [PubMed] [Europe PMC] [Abstract]
  18. "Nucleocytoplasmic shuttling of JAZ, a new cargo protein for exportin-5."Mol. Cell. Biol. 24:6608-6619(2004) [PubMed] [Europe PMC] [Abstract]
  19. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  20. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  21. "The nuclear PP1 interacting protein ZAP3 (ZAP) is a putative nucleoside kinase that complexes with SAM68, CIA, NF110/45, and HNRNP-G."Biochim. Biophys. Acta 1774:1339-1350(2007) [PubMed] [Europe PMC] [Abstract]
  22. "Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells."EMBO Rep. 8:1052-1060(2007) [PubMed] [Europe PMC] [Abstract]
  23. "Molecular composition of IMP1 ribonucleoprotein granules."Mol. Cell. Proteomics 6:798-811(2007) [PubMed] [Europe PMC] [Abstract]
  24. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  25. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  26. "Control of c-myc mRNA stability by IGF2BP1-associated cytoplasmic RNPs."RNA 15:104-115(2009) [PubMed] [Europe PMC] [Abstract]
  27. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  28. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  29. "Phosphorylation of the NFAR proteins by the dsRNA-dependent protein kinase PKR constitutes a novel mechanism of translational regulation and cellular defense."Genes Dev. 24:2640-2653(2010) [PubMed] [Europe PMC] [Abstract]
  30. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  31. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  32. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  33. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  34. "Crystal structure of DRBM 2 domain of interleukin enhancer-binding factor 3 from Homo sapiens, Northeast structural genomics consortium target HR4527E."Submitted (DEC-2010) to the PDB data bank
  35. "Northeast structural genomics consortium target HR4527E."Submitted (SEP-2010) to the PDB data bank