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Protein Kinase D1 (PKD1)

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PRKD1; PRK-D1; PKC-MU; PKCM; PK-D1; PRKCM; Protein Kinase C,Mu

Protein Kinase D1 (PKD1)
CCC A508
HGNC 9407
MGI 99879
PubMed 22791710
RGD 620964
UniProt Q15139
Wiki PRKD1

By screening a placenta cDNA library using a PCR fragment derived from the second conserved domain within the catalytic site of ser/thr protein kinases, Johannes et al. obtained a full-length cDNA encoding PKC-mu. The deduced 912-amino acid PRKCM protein has a calculated molecular mass of 102 kD. PRKCM has 2 characteristic cysteine-rich repeats, which are conserved among nearly all members of the PKC family, a conserved ATP-binding consensus sequence in the kinase domain, and the invariate aspartate essential for kinase activity. Northern blot analysis detected a single PRKCM transcript of 3.8 kb at low, constitutive levels in all tissues examined. The authors verified PRKCM kinase activity by transfection of a PRKCM expression vector and detecting changes in protein phosphorylation patterns by Western blot analysis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA508Hu01 Recombinant Protein Kinase D1 (PKD1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA508Hu01 Polyclonal Antibody to Protein Kinase D1 (PKD1) WB; IHC
Assay Kits n/a CLIA Kit for Protein Kinase D1 (PKD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Kinase D1 (PKD1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA508Mu01 Recombinant Protein Kinase D1 (PKD1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA508Mu01 Polyclonal Antibody to Protein Kinase D1 (PKD1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Protein Kinase D1 (PKD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Kinase D1 (PKD1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Kinase D1 (PKD1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Kinase D1 (PKD1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Kinase D1 (PKD1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Kinase D1 (PKD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Kinase D1 (PKD1) ELISA Kit Customized Service Offer
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  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
  4. "Cell-type specific phosphorylation of threonines T654 and T669 by PKD defines the signal capacity of the EGF receptor."EMBO J. 18:5567-5576(1999) [PubMed] [Europe PMC] [Abstract]
  5. "Proteolytic cleavage and activation of protein kinase C [micro] by caspase-3 in the apoptotic response of cells to 1-beta -D-arabinofuranosylcytosine and other genotoxic agents."J. Biol. Chem. 275:18476-18481(2000) [PubMed] [Europe PMC] [Abstract]
  6. "Centaurin-alpha(1) associates with and is phosphorylated by isoforms of protein kinase C."Biochem. Biophys. Res. Commun. 307:459-465(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Protein kinase D mediates a stress-induced NF-kappaB activation and survival pathway."EMBO J. 22:109-120(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Tyrosine phosphorylation of protein kinase D in the pleckstrin homology domain leads to activation."J. Biol. Chem. 278:17969-17976(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Interaction between protein kinase Cmu and the vanilloid receptor type 1."J. Biol. Chem. 279:53674-53682(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Protein kinase Cdelta selectively regulates protein kinase D-dependent activation of NF-kappaB in oxidative stress signaling."Mol. Cell. Biol. 24:2614-2626(2004) [PubMed] [Europe PMC] [Abstract]
  11. "DAP kinase regulates JNK signaling by binding and activating protein kinase D under oxidative stress."Cell Death Differ. 14:1908-1915(2007) [PubMed] [Europe PMC] [Abstract]
  12. "A novel tyrosine phosphorylation site in protein kinase D contributes to oxidative stress-mediated activation."J. Biol. Chem. 282:31873-31881(2007) [PubMed] [Europe PMC] [Abstract]
  13. "Protein kinase D interaction with TLR5 is required for inflammatory signaling in response to bacterial flagellin."J. Immunol. 178:5735-5743(2007) [PubMed] [Europe PMC] [Abstract]
  14. "Selective binding of phorbol esters and diacylglycerol by individual C1 domains of the PKD family."Biochem. J. 411:333-342(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Protein kinase D-dependent phosphorylation and nuclear export of histone deacetylase 5 mediates vascular endothelial growth factor-induced gene expression and angiogenesis."J. Biol. Chem. 283:14590-14599(2008) [PubMed] [Europe PMC] [Abstract]
  16. "Control of endothelial cell proliferation and migration by VEGF signaling to histone deacetylase 7."Proc. Natl. Acad. Sci. U.S.A. 105:7738-7743(2008) [PubMed] [Europe PMC] [Abstract]
  17. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Regulation of PKD by the MAPK p38delta in insulin secretion and glucose homeostasis."Cell 136:235-248(2009) [PubMed] [Europe PMC] [Abstract]
  19. "Protein kinase D controls the integrity of Golgi apparatus and the maintenance of dendritic arborization in hippocampal neurons."Mol. Biol. Cell 20:2108-2120(2009) [PubMed] [Europe PMC] [Abstract]
  20. "Protein kinase D: an intracellular traffic regulator on the move."Trends Cell Biol. 12:193-200(2002) [PubMed] [Europe PMC] [Abstract]
  21. "Protein kinase D signaling."J. Biol. Chem. 280:13205-13208(2005) [PubMed] [Europe PMC] [Abstract]
  22. "Protein kinase d in the cardiovascular system: emerging roles in health and disease."Circ. Res. 102:157-163(2008) [PubMed] [Europe PMC] [Abstract]
  23. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  24. "Protein kinase D1, a new molecular player in VEGF signaling and angiogenesis."Mol. Cells 28:1-5(2009) [PubMed] [Europe PMC] [Abstract]
  25. "Protein kinase D signaling: multiple biological functions in health and disease."Physiology (Bethesda) 26:23-33(2011) [PubMed] [Europe PMC] [Abstract]
  26. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  27. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
  28. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]