≡

Coilin (COIL)

[Edit]

CLN80; P80-Coilin

Coilin (COIL)
CCC A513
HGNC 2184
MGI 104842
PubMed 12361597
RGD 62031
UniProt P38432
Wiki Coilin

Coilin protein is one of the main molecular components of Cajal bodies (CBs). Cajal bodies are nuclear suborganelles of varying number and composition that are involved in the post-transcriptional modification of small nuclear and small nucleolar RNAs.

In addition to its structural role, coilin acts as glue to connect the CB to the nucleolus. The N-terminus of the coilin protein directs its self-oligomerization while the C-terminus influences the number of nuclear bodies assembled per cell. Differential methylation and phosphorylation of coilin likely influences its localization among nuclear bodies and the composition and assembly of Cajal bodies. This gene has pseudogenes on chromosome 4 and chromosome 14.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA513Hu01 Recombinant Coilin (COIL) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA513Hu01 Polyclonal Antibody to Coilin (COIL) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Coilin (COIL) CLIA Kit Customized Service Offer
n/a ELISA Kit for Coilin (COIL) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Coilin (COIL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Coilin (COIL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Coilin (COIL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Coilin (COIL) CLIA Kit Customized Service Offer
n/a ELISA Kit for Coilin (COIL) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Coilin (COIL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Coilin (COIL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Coilin (COIL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Coilin (COIL) CLIA Kit Customized Service Offer
n/a ELISA Kit for Coilin (COIL) ELISA Kit Customized Service Offer
  1. "Structure, expression and chromosomal localization of human p80-coilin gene."Nucleic Acids Res. 22:4462-4469(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Human autoantibody to a novel protein of the nuclear coiled body: immunological characterization and cDNA cloning of p80-coilin."J. Exp. Med. 173:1407-1419(1991) [PubMed] [Europe PMC] [Abstract]
  6. "Assembly of snRNP-containing coiled bodies is regulated in interphase and mitosis -- evidence that the coiled body is a kinetic nuclear structure."J. Cell Biol. 120:841-852(1993) [PubMed] [Europe PMC] [Abstract]
  7. "Coilin forms the bridge between Cajal bodies and SMN, the spinal muscular atrophy protein."Genes Dev. 15:2720-2729(2001) [PubMed] [Europe PMC] [Abstract]
  8. "Coilin methylation regulates nuclear body formation."Dev. Cell 3:329-337(2002) [PubMed] [Europe PMC] [Abstract]
  9. "A novel EB-1/AIDA-1 isoform, AIDA-1c, interacts with the Cajal body protein coilin."BMC Cell Biol. 6:23-23(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Characterization of hCINAP, a novel coilin-interacting protein encoded by a transcript from the transcription factor TAFIID32 locus."J. Biol. Chem. 280:36429-36441(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  12. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  13. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  17. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  18. "Substrate profiling of human vaccinia-related kinases identifies coilin, a Cajal body nuclear protein, as a phosphorylation target with neurological implications."J. Proteomics 75:548-560(2011) [PubMed] [Europe PMC] [Abstract]
  19. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  20. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  21. "Solution structure of the carboxy-terminal Tudor domain from human Coilin."FEBS Lett. 584:4351-4356(2010) [PubMed] [Europe PMC] [Abstract]