Platelet Derived Growth Factor Subunit A (PDGFA)
[Edit]PDGF-A; PDGF1; Platelet Derived Growth Factor Alpha Polypeptide
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Platelet-derived growth factor subunit A is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines.
This gene product can exist either as a homodimer or as a heterodimer with the platelet-derived growth factor beta polypeptide, where the dimers are connected by disulfide bonds. Studies using knockout mice have shown cellular defects in oligodendrocytes, alveolar smooth muscle cells, and Leydig cells in the testis; knockout mice die either as embryos or shortly after birth. Two splice variants have been identified for this gene.
Organism species: Homo sapiens (Human)
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA528Mu01 | Recombinant Platelet Derived Growth Factor Subunit A (PDGFA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPA528Mu02 | Recombinant Platelet Derived Growth Factor Subunit A (PDGFA) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| APA528Mu01 | Active Platelet Derived Growth Factor Subunit A (PDGFA) | Cell culture; Activity Assays. | |
| Antibodies | PAA528Mu01 | Polyclonal Antibody to Platelet Derived Growth Factor Subunit A (PDGFA) | WB; IHC; ICC; IP. |
| PAA528Mu02 | Polyclonal Antibody to Platelet Derived Growth Factor Subunit A (PDGFA) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA528Mu | ELISA Kit for Platelet Derived Growth Factor Subunit A (PDGFA) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA528Ra01 | Recombinant Platelet Derived Growth Factor Subunit A (PDGFA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| EPA528Ra61 | Eukaryotic Platelet Derived Growth Factor Subunit A (PDGFA) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAA528Ra01 | Polyclonal Antibody to Platelet Derived Growth Factor Subunit A (PDGFA) | WB; IHC; ICC; IP. |
| Assay Kits | SEA528Ra | ELISA Kit for Platelet Derived Growth Factor Subunit A (PDGFA) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Oryctolagus cuniculus (Rabbit)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA528Rb01 | Recombinant Platelet Derived Growth Factor Subunit A (PDGFA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA528Rb51 | Polyclonal Antibody to Platelet Derived Growth Factor Subunit A (PDGFA) | WB; IHC; ICC; IP. |
| MAA528Rb21 | Monoclonal Antibody to Platelet Derived Growth Factor Subunit A (PDGFA) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA528Rb | ELISA Kit for Platelet Derived Growth Factor Subunit A (PDGFA) | Enzyme-linked immunosorbent assay for Antigen Detection. |
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- "Alternative RNA splicing affects function of encoded platelet-derived growth factor A chain."Nature 328:621-624(1987) [PubMed] [Europe PMC] [Abstract]
- "Assignment of interchain disulfide bonds in platelet-derived growth factor (PDGF) and evidence for agonist activity of monomeric PDGF."J. Biol. Chem. 267:11260-11266(1992) [PubMed] [Europe PMC] [Abstract]
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- "Role of platelet-derived growth factors in physiology and medicine."Genes Dev. 22:1276-1312(2008) [PubMed] [Europe PMC] [Abstract]
- "Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex."Proc. Natl. Acad. Sci. U.S.A. 107:11307-11312(2010) [PubMed] [Europe PMC] [Abstract]