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Platelet Derived Growth Factor Subunit A (PDGFA)

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PDGF-A; PDGF1; Platelet Derived Growth Factor Alpha Polypeptide

Platelet Derived Growth Factor Subunit A (PDGFA)
CCC A528
HGNC 8799
MGI 97527
PubMed 12748302
RGD 3282
UniProt P04085
Wiki PDGFA

Platelet-derived growth factor subunit A is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines.

This gene product can exist either as a homodimer or as a heterodimer with the platelet-derived growth factor beta polypeptide, where the dimers are connected by disulfide bonds. Studies using knockout mice have shown cellular defects in oligodendrocytes, alveolar smooth muscle cells, and Leydig cells in the testis; knockout mice die either as embryos or shortly after birth. Two splice variants have been identified for this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA528Hu01 Recombinant Platelet Derived Growth Factor Subunit A (PDGFA) Positive Control; Immunogen; SDS-PAGE; WB.
APA528Hu01 Active Platelet Derived Growth Factor Subunit A (PDGFA) Cell culture; Activity Assays.
Antibodies MAA528Hu22 Monoclonal Antibody to Platelet Derived Growth Factor Subunit A (PDGFA) WB; IHC; ICC; IP.
LAA528Hu71 Biotin-Linked Polyclonal Antibody to Platelet Derived Growth Factor Subunit A (PDGFA) WB; IHC; ICC.
LAA528Hu81 FITC-Linked Polyclonal Antibody to Platelet Derived Growth Factor Subunit A (PDGFA) WB; IHC; ICC; IF.
MAA528Hu21 Monoclonal Antibody to Platelet Derived Growth Factor Subunit A (PDGFA) WB; IHC; ICC; IP.
MAA528Hu23 Monoclonal Antibody to Platelet Derived Growth Factor Subunit A (PDGFA) WB; IHC; ICC; IP.
Assay Kits SEA528Hu ELISA Kit for Platelet Derived Growth Factor Subunit A (PDGFA) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA528Mu01 Recombinant Platelet Derived Growth Factor Subunit A (PDGFA) Positive Control; Immunogen; SDS-PAGE; WB.
RPA528Mu02 Recombinant Platelet Derived Growth Factor Subunit A (PDGFA) Positive Control; Immunogen; SDS-PAGE; WB.
APA528Mu01 Active Platelet Derived Growth Factor Subunit A (PDGFA) Cell culture; Activity Assays.
Antibodies PAA528Mu01 Polyclonal Antibody to Platelet Derived Growth Factor Subunit A (PDGFA) WB; IHC; ICC; IP.
PAA528Mu02 Polyclonal Antibody to Platelet Derived Growth Factor Subunit A (PDGFA) WB; IHC; ICC; IP.
Assay Kits SEA528Mu ELISA Kit for Platelet Derived Growth Factor Subunit A (PDGFA) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA528Ra01 Recombinant Platelet Derived Growth Factor Subunit A (PDGFA) Positive Control; Immunogen; SDS-PAGE; WB.
EPA528Ra61 Eukaryotic Platelet Derived Growth Factor Subunit A (PDGFA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA528Ra01 Polyclonal Antibody to Platelet Derived Growth Factor Subunit A (PDGFA) WB; IHC; ICC; IP.
Assay Kits SEA528Ra ELISA Kit for Platelet Derived Growth Factor Subunit A (PDGFA) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA528Rb01 Recombinant Platelet Derived Growth Factor Subunit A (PDGFA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA528Rb51 Polyclonal Antibody to Platelet Derived Growth Factor Subunit A (PDGFA) WB; IHC; ICC; IP.
MAA528Rb21 Monoclonal Antibody to Platelet Derived Growth Factor Subunit A (PDGFA) WB; IHC; ICC; IP.
Assay Kits SEA528Rb ELISA Kit for Platelet Derived Growth Factor Subunit A (PDGFA) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Platelet-derived growth factor A chain: gene structure, chromosomal location, and basis for alternative mRNA splicing."Proc. Natl. Acad. Sci. U.S.A. 85:1492-1496(1988) [PubMed] [Europe PMC] [Abstract]
  2. "Structural characterization of the human platelet-derived growth factor A-chain cDNA and gene: alternative exon usage predicts two different precursor proteins."Mol. Cell. Biol. 8:571-577(1988) [PubMed] [Europe PMC] [Abstract]
  3. "cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines."Nature 320:695-699(1986) [PubMed] [Europe PMC] [Abstract]
  4. "The long 3'-untranslated regions of the PDGF-A and -B mRNAs are only distantly related."FEBS Lett. 223:243-246(1987) [PubMed] [Europe PMC] [Abstract]
  5. "Human protein factory for converting the transcriptome into an in vitro-expressed proteome." Nat. Methods 5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Nucleotide sequence of the 5' region of the human platelet-derived growth factor A-chain gene."Hiroshima J. Med. Sci. 42:47-52(1993) [PubMed] [Europe PMC] [Abstract]
  8. "Platelet-derived growth factor A chain: confirmation of localization of PDGFA to chromosome 7p22 and description of an unusual minisatellite."Genomics 13:257-263(1992) [PubMed] [Europe PMC] [Abstract]
  9. "cDNA clones reveal differences between human glial and endothelial cell platelet-derived growth factor A-chains."Nature 328:619-621(1987) [PubMed] [Europe PMC] [Abstract]
  10. "Alternative RNA splicing affects function of encoded platelet-derived growth factor A chain."Nature 328:621-624(1987) [PubMed] [Europe PMC] [Abstract]
  11. "Assignment of interchain disulfide bonds in platelet-derived growth factor (PDGF) and evidence for agonist activity of monomeric PDGF."J. Biol. Chem. 267:11260-11266(1992) [PubMed] [Europe PMC] [Abstract]
  12. "High-affinity binding of basic fibroblast growth factor and platelet-derived growth factor-AA to the core protein of the NG2 proteoglycan."J. Biol. Chem. 274:16831-16837(1999) [PubMed] [Europe PMC] [Abstract]
  13. "Role of platelet-derived growth factors in physiology and medicine."Genes Dev. 22:1276-1312(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex."Proc. Natl. Acad. Sci. U.S.A. 107:11307-11312(2010) [PubMed] [Europe PMC] [Abstract]