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Thrombomodulin (TM) is the cell surface receptor for thrombin. When occupied, thrombomodulin converts thrombin from a procoagulant protein into the activator of Protein C. Once activated Protein C (APC) has been generated, thrombomodulin acts as a major anticoagulant through its ability to inactivate various blood factors (Va, VΙΙΙa, Xa and XΙΙΙa). In competing for thrombin binding, thrombomodulin inhibits the proteolytic effect of thrombin in its clotting of fibrinogen, the inactivation of Protein S and the induction of platelet aggregation.
TM is an integral membrane glycoprotein resembling in structure the low-density lipoprotein (LDL) receptor.TM possesses several EGF repeats, of which numbers five and six are responsible for the high affinity binding of thrombin (Kd = 0.5 nM).
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA529Hu01 | Recombinant Thrombomodulin (TM) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPA529Hu02 | Recombinant Thrombomodulin (TM) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| RPA529Hu03 | Recombinant Thrombomodulin (TM) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| EPA529Hu62 | Eukaryotic Thrombomodulin (TM) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| APA529Hu61 | Active Thrombomodulin (TM) | Cell culture; Activity Assays. | |
| Antibodies | PAA529Hu01 | Polyclonal Antibody to Thrombomodulin (TM) | WB; IHC; ICC; IP. |
| MAA529Hu22 | Monoclonal Antibody to Thrombomodulin (TM) | WB; IHC; ICC; IP. | |
| LAA529Hu71 | Biotin-Linked Polyclonal Antibody to Thrombomodulin (TM) | WB; IHC; ICC. | |
| PAA529Hu02 | Polyclonal Antibody to Thrombomodulin (TM) | WB; IHC; ICC; IP. | |
| MAA529Hu21 | Monoclonal Antibody to Thrombomodulin (TM) | WB; IHC; ICC; IP. | |
| MAA529Hu23 | Monoclonal Antibody to Thrombomodulin (TM) | WB; IHC; ICC; IP. | |
| MAA529Hu24 | Monoclonal Antibody to Thrombomodulin (TM) | WB; IHC; ICC; IP. | |
| PAA529Hu03 | Polyclonal Antibody to Thrombomodulin (TM) | WB; IHC; ICC; IP. | |
| MAA529Hu25 | Monoclonal Antibody to Thrombomodulin (TM) | WB; IHC; ICC; IP. | |
| MAA529Hu27 | Monoclonal Antibody to Thrombomodulin (TM) | WB; IHC; ICC; IP. | |
| MAA529Hu28 | Monoclonal Antibody to Thrombomodulin (TM) | WB | |
| MAA529Hu29 | Monoclonal Antibody to Thrombomodulin (TM) | WB | |
| Assay Kits | SEA529Hu | ELISA Kit for Thrombomodulin (TM) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA529Mu01 | Recombinant Thrombomodulin (TM) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPA529Mu02 | Recombinant Thrombomodulin (TM) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAA529Mu01 | Polyclonal Antibody to Thrombomodulin (TM) | WB; IHC; ICC; IP. |
| LAA529Mu71 | Biotin-Linked Polyclonal Antibody to Thrombomodulin (TM) | WB; IHC; ICC. | |
| PAA529Mu02 | Polyclonal Antibody to Thrombomodulin (TM) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA529Mu | ELISA Kit for Thrombomodulin (TM) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SCA529Mu | CLIA Kit for Thrombomodulin (TM) | Chemiluminescent immunoassay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA529Ra01 | Recombinant Thrombomodulin (TM) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPA529Ra02 | Recombinant Thrombomodulin (TM) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| RPA529Ra03 | Recombinant Thrombomodulin (TM) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| EPA529Ra61 | Eukaryotic Thrombomodulin (TM) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| APA529Ra61 | Active Thrombomodulin (TM) | Cell culture; Activity Assays. | |
| Antibodies | PAA529Ra01 | Polyclonal Antibody to Thrombomodulin (TM) | WB; IHC; ICC; IP. |
| PAA529Ra02 | Polyclonal Antibody to Thrombomodulin (TM) | WB; IHC; ICC; IP. | |
| LAA529Ra71 | Biotin-Linked Polyclonal Antibody to Thrombomodulin (TM) | WB; IHC; ICC. | |
| Assay Kits | SEA529Ra | ELISA Kit for Thrombomodulin (TM) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Oryctolagus cuniculus (Rabbit)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA529Rb01 | Recombinant Thrombomodulin (TM) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA529Rb51 | Polyclonal Antibody to Thrombomodulin (TM) | WB; IHC; ICC; IP. |
| MAA529Rb21 | Monoclonal Antibody to Thrombomodulin (TM) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA529Rb | ELISA Kit for Thrombomodulin (TM) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Canis familiaris; Canine (Dog)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA529Ca01 | Recombinant Thrombomodulin (TM) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA529Ca01 | Polyclonal Antibody to Thrombomodulin (TM) | WB; IHC; ICC; IP. |
| MAA529Ca21 | Monoclonal Antibody to Thrombomodulin (TM) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA529Ca | ELISA Kit for Thrombomodulin (TM) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Sus scrofa; Porcine (Pig)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA529Po01 | Recombinant Thrombomodulin (TM) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA529Po01 | Polyclonal Antibody to Thrombomodulin (TM) | WB; IHC; ICC; IP. |
| MAA529Po21 | Monoclonal Antibody to Thrombomodulin (TM) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA529Po | ELISA Kit for Thrombomodulin (TM) | Enzyme-linked immunosorbent assay for Antigen Detection. |
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- "Thrombomodulin mutations in atypical hemolytic-uremic syndrome."N. Engl. J. Med. 361:345-357(2009) [PubMed] [Europe PMC] [Abstract]
- "Mutations in alternative pathway complement proteins in American patients with atypical hemolytic uremic syndrome."Hum. Mutat. 31:E1445-E1460(2010) [PubMed] [Europe PMC] [Abstract]