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Intercellular Adhesion Molecule 3 (ICAM3)

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CDW50; CD50; ICAM-R

Intercellular Adhesion Molecule 3 (ICAM3)
CCC A533
HGNC 5346
PubMed 11812993
UniProt P32942
Wiki ICAM3

The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the initiation of the immune response.

It functions not only as an adhesion molecule, but also as a potent signalling molecule.Using the cDNA as a probe, Bossy et al. (1994) mapped the ICAM3 gene to 19p13.3-p13.2 by isotopic in situ hybridization. They also mapped the gene to chromosome 19 by PCR amplification of DNAs from somatic cell hybrids. ICAM1 maps to the same region of chromosome 19.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA533Hu01 Recombinant Intercellular Adhesion Molecule 3 (ICAM3) Positive Control; Immunogen; SDS-PAGE; WB.
RPA533Hu02 Recombinant Intercellular Adhesion Molecule 3 (ICAM3) Positive Control; Immunogen; SDS-PAGE; WB.
RPA533Hu03 Recombinant Intercellular Adhesion Molecule 3 (ICAM3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA533Hu01 Polyclonal Antibody to Intercellular Adhesion Molecule 3 (ICAM3) WB; IHC; ICC; IP.
MAA533Hu22 Monoclonal Antibody to Intercellular Adhesion Molecule 3 (ICAM3) WB; IHC; ICC; IP.
PAA533Hu02 Polyclonal Antibody to Intercellular Adhesion Molecule 3 (ICAM3) WB,IHC
Assay Kits n/a CLIA Kit for Intercellular Adhesion Molecule 3 (ICAM3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Intercellular Adhesion Molecule 3 (ICAM3) ELISA Kit Customized Service Offer

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Intercellular Adhesion Molecule 3 (ICAM3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Intercellular Adhesion Molecule 3 (ICAM3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Intercellular Adhesion Molecule 3 (ICAM3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Intercellular Adhesion Molecule 3 (ICAM3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Intercellular Adhesion Molecule 3 (ICAM3) ELISA Kit Customized Service Offer
  1. "Molecular cloning of ICAM-3, a third ligand for LFA-1, constitutively expressed on resting leukocytes."Nature 360:481-484(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and characterization of a new intercellular adhesion molecule ICAM-R."Nature 360:485-488(1992) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning and expression of intercellular adhesion molecule 3 reveals strong homology to other immunoglobulin family counter-receptors for lymphocyte function-associated antigen 1."J. Exp. Med. 177:1187-1192(1993) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "CDw50 and ICAM-3: two names for the same molecule."Eur. J. Immunol. 23:1508-1512(1993) [PubMed] [Europe PMC] [Abstract]
  6. "Structural study of N-linked oligosaccharides of human intercellular adhesion molecule-3 (CD50)."Eur. J. Biochem. 268:1020-1029(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "An atomic resolution view of ICAM recognition in a complex between the binding domains of ICAM-3 and integrin alphaLbeta2."Proc. Natl. Acad. Sci. U.S.A. 102:3366-3371(2005) [PubMed] [Europe PMC] [Abstract]