Tissue Inhibitors Of Metalloproteinase 1 (TIMP1)

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EPO; CLGI; EPA; HCI; Erythroid Potentiating Activity; Collagenase Inhibitor; Metalloproteinase inhibitor 1; Fibroblast collagenase inhibitor

Tissue Inhibitors Of Metalloproteinase 1 (TIMP1)

TIMP metallopeptidase inhibitor 1, a member of the TIMP family. The glycoprotein is a natural inhibitor of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function.

Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA552Hu01 Recombinant Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) Positive Control; Immunogen; SDS-PAGE; WB.
EPA552Hu61 Eukaryotic Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) Positive Control; Immunogen; SDS-PAGE; WB.
APA552Hu61 Active Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) Cell culture; Activity Assays.
APA552Hu01 Active Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) Cell culture; Activity Assays.
Antibodies PAA552Hu01 Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) WB; IHC; ICC; IP.
MAA552Hu22 Monoclonal Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) WB; IHC; ICC; IP.
LAA552Hu71 Biotin-Linked Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) WB; IHC; ICC.
MAA552Hu21 Monoclonal Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) WB; IHC; ICC; IP.
MAA552Hu23 Monoclonal Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) WB; IHC; ICC; IP.
MAA552Hu24 Monoclonal Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) WB; IHC; ICC; IP.
MAA552Hu25 Monoclonal Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) WB; IHC; ICC; IP.
MAA552Hu27 Monoclonal Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) WB; IHC; ICC; IP.
Assay Kits SEA552Hu ELISA Kit for Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA552Hu CLIA Kit for Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA552Mu01 Recombinant Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA552Mu02 Recombinant Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA552Mu01 Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) WB; IHC; ICC; IP.
LAA552Mu71 Biotin-Linked Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) WB; IHC; ICC.
PAA552Mu02 Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) WB; IHC; ICC; IP.
Assay Kits SEA552Mu ELISA Kit for Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA552Mu CLIA Kit for Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA552Ra01 Recombinant Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) Positive Control; Immunogen; SDS-PAGE; WB.
EPA552Ra61 Eukaryotic Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) Positive Control; Immunogen; SDS-PAGE; WB.
APA552Ra61 Active Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) Cell culture; Activity Assays.
APA552Ra01 Active Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) Cell culture; Activity Assays.
Antibodies PAA552Ra01 Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) WB; IHC; ICC; IP.
LAA552Ra71 Biotin-Linked Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) WB; IHC; ICC.
LAA552Ra81 FITC-Linked Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) WB; IHC; ICC; IF.
MAA552Ra21 Monoclonal Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) WB
Assay Kits SEA552Ra ELISA Kit for Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA552Ra CLIA Kit for Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA552Rb01 Recombinant Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA552Rb02 Recombinant Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA552Rb52 Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) WB; IHC; ICC; IP.
PAA552Rb51 Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) WB; IHC; ICC; IP.
LAA552Rb71 Biotin-Linked Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) WB; IHC; ICC.
LAA552Rb81 FITC-Linked Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) WB; IHC; ICC; IF.
Assay Kits SEA552Rb ELISA Kit for Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Canis familiaris; Canine (Dog)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA552Ca01 Recombinant Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) Positive Control; Immunogen; SDS-PAGE; WB.
APA552Ca01 Active Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) Cell culture; Activity Assays.
Antibodies PAA552Ca01 Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) WB; IHC; ICC; IP.
LAA552Ca71 Biotin-Linked Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) WB; IHC; ICC.
MAA552Ca21 Monoclonal Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) WB; IHC; ICC; IP.
Assay Kits SEA552Ca ELISA Kit for Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA552Po01 Recombinant Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA552Po01 Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) WB; IHC; ICC; IP.
MAA552Po21 Monoclonal Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) WB; IHC; ICC; IP.
Assay Kits SEA552Po ELISA Kit for Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA552Bo01 Recombinant Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA552Bo01 Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) WB; IHC; ICC; IP.
MAA552Bo21 Monoclonal Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) WB; IHC; ICC; IP.
Assay Kits SEA552Bo ELISA Kit for Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Ovis aries; Ovine (Sheep)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA552Ov01 Recombinant Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) Positive Control; Immunogen; SDS-PAGE; WB.
APA552Ov01 Active Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) Cell culture; Activity Assays.
Antibodies PAA552Ov01 Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) WB; IHC; ICC; IP.
Assay Kits SEA552Ov ELISA Kit for Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Equus caballus; Equine (Horse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA552Eq01 Recombinant Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA552Eq01 Polyclonal Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) WB; IHC; ICC; IP.
MAA552Eq21 Monoclonal Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) WB; IHC; ICC; IP.
Assay Kits SEA552Eq ELISA Kit for Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) Enzyme-linked immunosorbent assay for Antigen Detection.
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  18. "Identification of CD63 as a tissue inhibitor of metalloproteinase-1 interacting cell surface protein."EMBO J. 25:3934-3942(2006) [PubMed] [Europe PMC] [Abstract]
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  20. "Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach."Mol. Cell. Proteomics 5:226-233(2006) [PubMed] [Europe PMC] [Abstract]
  21. "A strategy for precise and large scale identification of core fucosylated glycoproteins."Mol. Cell. Proteomics 8:913-923(2009) [PubMed] [Europe PMC] [Abstract]
  22. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  23. "Resveratrol-induced changes of the human adipocyte secretion profile."J. Proteome Res. 11:4733-4743(2012) [PubMed] [Europe PMC] [Abstract]
  24. "Timp1 interacts with beta-1 integrin and CD63 along melanoma genesis and confers anoikis resistance by activating PI3-K signaling pathway independently of Akt phosphorylation."Mol. Cancer 12:22-22(2013) [PubMed] [Europe PMC] [Abstract]
  25. "TIMP-1 modulates chemotaxis of human neural stem cells through CD63 and integrin signalling."Biochem. J. 459:565-576(2014) [PubMed] [Europe PMC] [Abstract]
  26. "Cytokine functions of TIMP-1."Cell. Mol. Life Sci. 71:659-672(2014) [PubMed] [Europe PMC] [Abstract]
  27. "Mechanism of inhibition of the human matrix metalloproteinase stromelysin-1 by TIMP-1."Nature 389:77-81(1997) [PubMed] [Europe PMC] [Abstract]
  28. "NMR structure of tissue inhibitor of metalloproteinases-1 implicates localized induced fit in recognition of matrix metalloproteinases."J. Mol. Biol. 295:257-268(2000) [PubMed] [Europe PMC] [Abstract]
  29. "Global orientation of bound MMP-3 and N-TIMP-1 in solution via residual dipolar couplings."Biochemistry 42:7950-7958(2003) [PubMed] [Europe PMC] [Abstract]
  30. "Crystal structure of the catalytic domain of matrix metalloproteinase-1 in complex with the inhibitory domain of tissue inhibitor of metalloproteinase-1."J. Biol. Chem. 282:364-371(2007) [PubMed] [Europe PMC] [Abstract]
  31. "The intrinsic protein flexibility of endogenous protease inhibitor TIMP-1 controls its binding interface and affects its function."Biochemistry 49:6184-6192(2010) [PubMed] [Europe PMC] [Abstract]
  32. "Matrix metalloproteinase-10 (MMP10) interaction with tissue inhibitors of metalloproteinases TIMP-1 and TIMP-2: binding studies and crystal structure."J. Biol. Chem. 287:15935-15946(2012) [PubMed] [Europe PMC] [Abstract]