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Nicotinamide Adenine Dinucleotide Phosphate Oxidase 5 (NOX5)

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NOX5A; NOX5B; NOX5-A; NOX5-B; NADPH Oxidase,EF-Hand Calcium Binding Domain 5

Nicotinamide Adenine Dinucleotide Phosphate Oxidase 5 (NOX5)
CCC A555
HGNC 14874
PubMed 22291013
UniProt Q96PH1
Wiki NOX5

  • NOX5 is distantly related to the gp91-phox subunit of the phagocyte NADPH oxidase with conserved regions crucial for electron transport (NADPH, FAD, and heme binding sites). However, NOX5 has a unique N-terminal extension that contains 3 EF-hand motifs.

  • Banfi et al. (2001) demonstrated 2 NOX5 isoforms of 737 and 719 amino acids, designated NOX5A and NOX5B, respectively. Northern blot analysis demonstrated restricted expression of an approximately 2.7-kb NOX5A transcript in spleen and an approximately 2.9-kb NOX5B transcript in testis. In situ hybridization localized NOX5 in pachytene spermatocytes of testis and in B- and T-lymphocytic-rich areas of spleen and lymph nodes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA555Hu01 Recombinant Nicotinamide Adenine Dinucleotide Phosphate Oxidase 5 (NOX5) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA555Hu01 Polyclonal Antibody to Nicotinamide Adenine Dinucleotide Phosphate Oxidase 5 (NOX5) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Nicotinamide Adenine Dinucleotide Phosphate Oxidase 5 (NOX5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nicotinamide Adenine Dinucleotide Phosphate Oxidase 5 (NOX5) ELISA Kit Customized Service Offer
  1. "A Ca(2+)-activated NADPH oxidase in testis, spleen, and lymph nodes."J. Biol. Chem. 276:37594-37601(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Analysis of the DNA sequence and duplication history of human chromosome 15." Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Point mutations in the proline-rich region of p22phox are dominant inhibitors of Nox1- and Nox2-dependent reactive oxygen generation."J. Biol. Chem. 280:31859-31869(2005) [PubMed] [Europe PMC] [Abstract]
  6. "Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, and Nox5."Gene 269:131-140(2001) [PubMed] [Europe PMC] [Abstract]
  7. "NOX5 NAD(P)H oxidase regulates growth and apoptosis in DU 145 prostate cancer cells."Am. J. Physiol. 285:C353-C369(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Mechanism of Ca2+ activation of the NADPH oxidase 5 (NOX5)."J. Biol. Chem. 279:18583-18591(2004) [PubMed] [Europe PMC] [Abstract]
  9. "NAD(P)H oxidase 4 mediates transforming growth factor-beta1-induced differentiation of cardiac fibroblasts into myofibroblasts."Circ. Res. 97:900-907(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Expression and activity of NOX5 in the circulating malignant B cells of hairy cell leukemia."J. Immunol. 175:8424-8430(2005) [PubMed] [Europe PMC] [Abstract]
  11. "NOX5 variants are functionally active in endothelial cells."Free Radic. Biol. Med. 42:446-459(2007) [PubMed] [Europe PMC] [Abstract]