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Telomerase protein component 1 (TEP1)

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TLP1; TP1; TROVE1; VAULT2; p240; TROVE Domain Family Member 1; Telomerase protein component 1; p80 telomerase homolog

Telomerase protein component 1 (TEP1)
CCC A558
HGNC 11726
MGI 109573
PubMed 11027287
RGD 3869
UniProt Q99973
Wiki TEP1

Telomerase-associated protein 1 (TEP1) is a component of the telomerase ribonucleoprotein complex, which catalyzes the addition of new telomeres on the chromosome ends. This activity is mediated by the catalytic telomerase reverse transcriptase (TERT) and telomerase RNA component template (TERC).

The ribonucleoprotein complex responsible for telomerase activity had been purified only in ciliates. Purified tetrahymena telomerase contains an RNA and 2 protein components, p80 and p95. The p80 component can be specifically cross linked to telomerase RNA, whereas the p95 component binds and cross links to single-stranded, telomeric DNA (Harrington et al., 1997).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA558Hu01 Recombinant Telomerase protein component 1 (TEP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA558Hu01 Polyclonal Antibody to Telomerase protein component 1 (TEP1) WB; IHC; ICC; IP.
MAA558Hu22 Monoclonal Antibody to Telomerase protein component 1 (TEP1) WB; IHC; ICC; IP.
Assay Kits SEA558Hu ELISA Kit for Telomerase protein component 1 (TEP1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Telomerase protein component 1 (TEP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Telomerase protein component 1 (TEP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Telomerase protein component 1 (TEP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Telomerase protein component 1 (TEP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Telomerase protein component 1 (TEP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Telomerase protein component 1 (TEP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Telomerase protein component 1 (TEP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Telomerase protein component 1 (TEP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Telomerase protein component 1 (TEP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Telomerase protein component 1 (TEP1) ELISA Kit Customized Service Offer
  1. "A mammalian telomerase-associated protein."Science 275:973-977(1997) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "Human telomerase contains evolutionarily conserved catalytic and structural subunits."Genes Dev. 11:3109-3115(1997) [PubMed] [Europe PMC] [Abstract]
  5. "Vaults and telomerase share a common subunit, TEP1."J. Biol. Chem. 274:32712-32717(1999) [PubMed] [Europe PMC] [Abstract]
  6. "Polymerization defects within human telomerase are distinct from telomerase RNA and TEP1 binding."Mol. Biol. Cell 11:3329-3340(2000) [PubMed] [Europe PMC] [Abstract]
  7. "A human telomerase holoenzyme protein required for Cajal body localization and telomere synthesis."Science 323:644-648(2009) [PubMed] [Europe PMC] [Abstract]