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Thrombospondin 1 (THBS1)

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TSP1; Thrombospondin-1p180

Thrombospondin 1 (THBS1)
CCC A611
HGNC 11785
MGI 98737
PubMed 21526452
RGD 1588455
UniProt P07996
Wiki THBS1

Thrombospondin-1 (TSP-1) is a 150 - 180 kDa charter member of the thrombospondin family of extracellular matrix proteins.1 - 4 Human TSP-1 is synthesized as an 1170 amino acid (aa) precursor that contains an 18 aa signal sequence and 1152 aa mature molecule. The mature molecule has been described as containing three distinct regions that create the shape of a dumbbell. There is an intital, 140 aa N-terminal laminin G-like globular region that binds heparin (aa 19 - 258). This is followed by an extended, central collagen-binding region that contains one type C von Willebrand factor domain, plus three TSP type I and three TSP type II (or EGF-like) domains (aa 259 - 712). The type I repeats have multiple functions. They bind to type IV collagen, laminin, fibronectin and CD36.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA611Hu01 Recombinant Thrombospondin 1 (THBS1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA611Hu02 Recombinant Thrombospondin 1 (THBS1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA611Hu01 Polyclonal Antibody to Thrombospondin 1 (THBS1) WB; IHC; ICC; IP.
MAA611Hu22 Monoclonal Antibody to Thrombospondin 1 (THBS1) WB; IHC; ICC; IP.
LAA611Hu71 Biotin-Linked Polyclonal Antibody to Thrombospondin 1 (THBS1) WB; IHC; ICC.
PAA611Hu02 Polyclonal Antibody to Thrombospondin 1 (THBS1) WB; IHC; ICC; IP.
Assay Kits SEA611Hu ELISA Kit for Thrombospondin 1 (THBS1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA611Mu01 Recombinant Thrombospondin 1 (THBS1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA611Mu02 Recombinant Thrombospondin 1 (THBS1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA611Mu03 Recombinant Thrombospondin 1 (THBS1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA611Mu01 Polyclonal Antibody to Thrombospondin 1 (THBS1) WB; IHC; ICC; IP.
PAA611Mu02 Polyclonal Antibody to Thrombospondin 1 (THBS1) WB; IHC; ICC; IP.
PAA611Mu03 Polyclonal Antibody to Thrombospondin 1 (THBS1) WB; IHC; ICC; IP.
LAA611Mu71 Biotin-Linked Polyclonal Antibody to Thrombospondin 1 (THBS1) WB; IHC; ICC.
Assay Kits SEA611Mu ELISA Kit for Thrombospondin 1 (THBS1) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA611Mu CLIA Kit for Thrombospondin 1 (THBS1) Chemiluminescent immunoassay for Antigen Detection.
HEA611Mu High Sensitive ELISA Kit for Thrombospondin 1 (THBS1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA611Ra01 Recombinant Thrombospondin 1 (THBS1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA611Ra02 Recombinant Thrombospondin 1 (THBS1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA611Ra03 Recombinant Thrombospondin 1 (THBS1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA611Ra04 Recombinant Thrombospondin 1 (THBS1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA611Ra01 Polyclonal Antibody to Thrombospondin 1 (THBS1) WB; IHC; ICC; IP.
PAA611Ra03 Polyclonal Antibody to Thrombospondin 1 (THBS1) WB; IHC; ICC; IP.
PAA611Ra02 Polyclonal Antibody to Thrombospondin 1 (THBS1) WB; IHC; ICC; IP.
LAA611Ra71 Biotin-Linked Polyclonal Antibody to Thrombospondin 1 (THBS1) WB; IHC; ICC.
PAA611Ra04 Polyclonal Antibody to Thrombospondin 1 (THBS1) WB; IHC; ICC; IP.
Assay Kits SEA611Ra ELISA Kit for Thrombospondin 1 (THBS1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Thrombospondin 1 (THBS1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Thrombospondin 1 (THBS1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Thrombospondin 1 (THBS1) Polyclonal Antibody Customized Service Offer
Assay Kits SEA611Po ELISA Kit for Thrombospondin 1 (THBS1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA611Bo01 Recombinant Thrombospondin 1 (THBS1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA611Bo01 Polyclonal Antibody to Thrombospondin 1 (THBS1) WB; IHC; ICC; IP.
MAA611Bo21 Monoclonal Antibody to Thrombospondin 1 (THBS1) WB; IHC; ICC; IP.
Assay Kits SEA611Bo ELISA Kit for Thrombospondin 1 (THBS1) Enzyme-linked immunosorbent assay for Antigen Detection.
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  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Analysis of the DNA sequence and duplication history of human chromosome 15." Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
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  7. "Characterization of a cDNA encoding the heparin and collagen binding domains of human thrombospondin."Proc. Natl. Acad. Sci. U.S.A. 83:5449-5453(1986) [PubMed] [Europe PMC] [Abstract]
  8. "Characterization of the promoter region of the human thrombospondin gene. DNA sequences within the first intron increase transcription."J. Biol. Chem. 264:11222-11227(1989) [PubMed] [Europe PMC] [Abstract]
  9. "Thrombospondin sequence motif (CSVTCG) is responsible for CD36 binding."Biochem. Biophys. Res. Commun. 182:1208-1217(1992) [PubMed] [Europe PMC] [Abstract]
  10. "C-mannosylation and O-fucosylation of the thrombospondin type 1 module."J. Biol. Chem. 276:6485-6498(2001) [PubMed] [Europe PMC] [Abstract]
  11. "Histidine-rich glycoprotein inhibits the antiangiogenic effect of thrombospondin-1."J. Clin. Invest. 107:45-52(2001) [PubMed] [Europe PMC] [Abstract]
  12. "Biophysical characterization, including disulfide bond assignments, of the anti-angiogenic type 1 domains of human thrombospondin-1."Biochemistry 41:14329-14339(2002) [PubMed] [Europe PMC] [Abstract]
  13. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  14. "Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry."J. Proteome Res. 5:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]
  15. "Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach."Mol. Cell. Proteomics 5:226-233(2006) [PubMed] [Europe PMC] [Abstract]
  16. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  18. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  19. "Crystal structure of the TSP-1 type 1 repeats: a novel layered fold and its biological implication."J. Cell Biol. 159:373-382(2002) [PubMed] [Europe PMC] [Abstract]
  20. "Structure of a thrombospondin C-terminal fragment reveals a novel calcium core in the type 3 repeats."EMBO J. 23:1223-1233(2004) [PubMed] [Europe PMC] [Abstract]
  21. "The structures of the thrombospondin-1 N-terminal domain and its complex with a synthetic pentameric heparin."Structure 14:33-42(2006) [PubMed] [Europe PMC] [Abstract]
  22. "Heparin-induced cis- and trans-dimerization modes of the thrombospondin-1 N-terminal domain."J. Biol. Chem. 283:3932-3941(2008) [PubMed] [Europe PMC] [Abstract]