Tachykinin Receptor 2 (TACR2)
[Edit]NK2-R; NK2R; NKNAR; SKR; TAC2R; Substance-K Receptor; Neurokinin A Receptor
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Substance-K receptor is a protein belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neuropeptide substance K, also referred to as neurokinin A. Several selective ligands for NK2 are now available, and although most of the compounds developed so far are peptides, one small-molecule antagonist Saredutant is currently in clinical trials as an anxiolytic and antidepressant.the TACR2 gene to chromosome 10. They confirmed the assignment by in situ hybridization which gave a regional localization of 10q11-q21.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA618Hu01 | Recombinant Tachykinin Receptor 2 (TACR2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA618Hu01 | Polyclonal Antibody to Tachykinin Receptor 2 (TACR2) | WB; IHC; ICC; IP. |
| MAA618Hu22 | Monoclonal Antibody to Tachykinin Receptor 2 (TACR2) | WB; IHC; ICC; IP. | |
| Assay Kits | n/a | CLIA Kit for Tachykinin Receptor 2 (TACR2) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Tachykinin Receptor 2 (TACR2) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA618Mu01 | Recombinant Tachykinin Receptor 2 (TACR2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA618Mu01 | Polyclonal Antibody to Tachykinin Receptor 2 (TACR2) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Tachykinin Receptor 2 (TACR2) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Tachykinin Receptor 2 (TACR2) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA618Ra01 | Recombinant Tachykinin Receptor 2 (TACR2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA618Ra01 | Polyclonal Antibody to Tachykinin Receptor 2 (TACR2) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Tachykinin Receptor 2 (TACR2) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Tachykinin Receptor 2 (TACR2) | ELISA Kit Customized Service Offer |
Organism species: Oryctolagus cuniculus (Rabbit)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Tachykinin Receptor 2 (TACR2) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Tachykinin Receptor 2 (TACR2) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Tachykinin Receptor 2 (TACR2) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Tachykinin Receptor 2 (TACR2) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Tachykinin Receptor 2 (TACR2) | ELISA Kit Customized Service Offer |
- "The human neurokinin A (substance K) receptor. Molecular cloning of the gene, chromosome localization, and isolation of cDNA from tracheal and gastric tissues."J. Biol. Chem. 265:20455-20462(1990) [PubMed] [Europe PMC] [Abstract]
- ErratumJ. Biol. Chem. 266:1354-1354(1991) [PubMed] [Europe PMC] [Abstract]
- "Molecular cloning of the human neurokinin-2 receptor cDNA by polymerase chain reaction and isolation of the gene."Ann. N. Y. Acad. Sci. 632:389-390(1991) [PubMed] [Europe PMC] [Abstract]
- "Cloning, expression of the human substance K receptor, and analysis of its role in mitogenesis."Ann. N. Y. Acad. Sci. 632:426-427(1991) [PubMed] [Europe PMC] [Abstract]
- "Isolation and characterisation of the human lung NK-2 receptor gene using rapid amplification of cDNA ends."Biochem. Biophys. Res. Commun. 177:8-16(1991) [PubMed] [Europe PMC] [Abstract]
- "Cloning and expression of the human substance K receptor and analysis of its role in mitogenesis."Cell Growth Differ. 2:15-22(1991) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]