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Nitric Oxide Synthase Trafficker (NOSTRIN)

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BM247 homolog; Nitric oxide synthase traffic inducer; eNOS-trafficking inducer

Nitric Oxide Synthase Trafficker (NOSTRIN)
CCC A628
HGNC 20203
MGI 3606242
PubMed 12446846
RGD 727920
UniProt Q8IVI9

  • Nitric oxide (NO) is a potent mediator in biologic processes such as neurotransmission, inflammatory response, and vascular homeostasis. NOSTRIN binds the enzyme responsible for NO production, endothelial NO synthase (ENOS), and triggers the translocation of ENOS from the plasma membrane to vesicle-like subcellular structures, thereby attenuating ENOS-dependent NO production.

  • NOSTRIN overexpression induced a redistribution of ENOS from the plasma membrane to vesicle-like structures matching the NOSTRIN localization pattern and, at the same time, led to significant inhibition of NO release. Deletion of the CDC15 domain of NOSTRIN disrupted the subcellular distribution of both NOSTRIN and ENOS in these cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA628Hu01 Recombinant Nitric Oxide Synthase Trafficker (NOSTRIN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA628Hu01 Polyclonal Antibody to Nitric Oxide Synthase Trafficker (NOSTRIN) WB; IHC; ICC; IP.
MAA628Hu22 Monoclonal Antibody to Nitric Oxide Synthase Trafficker (NOSTRIN) WB; IHC; ICC; IP.
Assay Kits SEA628Hu ELISA Kit for Nitric Oxide Synthase Trafficker (NOSTRIN) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA628Mu01 Recombinant Nitric Oxide Synthase Trafficker (NOSTRIN) Positive Control; Immunogen; SDS-PAGE; WB.
APA628Mu01 Active Nitric Oxide Synthase Trafficker (NOSTRIN) Cell culture; Activity Assays.
Antibodies PAA628Mu01 Polyclonal Antibody to Nitric Oxide Synthase Trafficker (NOSTRIN) WB; IHC; ICC; IP.
Assay Kits SEA628Mu ELISA Kit for Nitric Oxide Synthase Trafficker (NOSTRIN) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA628Ra01 Recombinant Nitric Oxide Synthase Trafficker (NOSTRIN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA628Ra01 Polyclonal Antibody to Nitric Oxide Synthase Trafficker (NOSTRIN) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Nitric Oxide Synthase Trafficker (NOSTRIN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nitric Oxide Synthase Trafficker (NOSTRIN) ELISA Kit Customized Service Offer
  1. "NOSTRIN: a protein modulating nitric oxide release and subcellular distribution of endothelial nitric oxide synthase."Proc. Natl. Acad. Sci. U.S.A. 99:17167-17172(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Altered gene expression in cerebral capillaries of stroke-prone spontaneously hypertensive rats."Brain Res. 910:106-115(2001) [PubMed] [Europe PMC] [Abstract]
  6. "Expression of endothelial nitric oxide synthase traffic inducer in the placentas of women with pre-eclampsia."Int. J. Gynecol. Obstet. 89:103-107(2005) [PubMed] [Europe PMC] [Abstract]
  7. "NOSTRIN functions as a homotrimeric adaptor protein facilitating internalization of eNOS."J. Cell Sci. 118:5059-5069(2005) [PubMed] [Europe PMC] [Abstract]
  8. "FCH/Cdc15 domain determines distinct subcellular localization of NOSTRIN."FEBS Lett. 580:223-228(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Translocation of endothelial nitric-oxide synthase involves a ternary complex with caveolin-1 and NOSTRIN."Mol. Biol. Cell 17:3870-3880(2006) [PubMed] [Europe PMC] [Abstract]
  10. "NOSTRINbeta--a shortened NOSTRIN variant with a role in transcriptional regulation."Traffic 10:26-34(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Solution structure of the SH3 domain of human nostrin."Submitted (OCT-2007) to the PDB data bank