Glycogen synthase kinase 3 is a serine/threonine protein kinase, that mediates the addition of phosphate molecules on certain serine and threonine amino acids in particular cellular substrates. The phosphorylation of these other proteins by GSK-3 usually inhibits the target protein.As mentioned, GSK-3 is known for phosphorylating and thus inactivating glycogen synthase.
Glycogen synthase kinase 3-alpha (GSK3A) is a multifunctional protein serine kinase, homologous to Drosophila 'shaggy' (zeste-white3) and implicated in the control of several regulatory proteins including glycogen synthase and transcription factors.It also plays a role in the WNT and PI3K signaling pathways.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPA630Hu01 | Recombinant Glycogen Synthase Kinase 3 Alpha (GSK3a) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAA630Hu01 | Polyclonal Antibody to Glycogen Synthase Kinase 3 Alpha (GSK3a) | WB; IHC; ICC; IP. |
MAA630Hu22 | Monoclonal Antibody to Glycogen Synthase Kinase 3 Alpha (GSK3a) | WB; IHC; ICC; IP. | |
Assay Kits | SEA630Hu | ELISA Kit for Glycogen Synthase Kinase 3 Alpha (GSK3a) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPA630Mu01 | Recombinant Glycogen Synthase Kinase 3 Alpha (GSK3a) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAA630Mu01 | Polyclonal Antibody to Glycogen Synthase Kinase 3 Alpha (GSK3a) | WB; IHC; ICC; IP. |
Assay Kits | n/a | CLIA Kit for Glycogen Synthase Kinase 3 Alpha (GSK3a) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Glycogen Synthase Kinase 3 Alpha (GSK3a) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPA630Ra01 | Recombinant Glycogen Synthase Kinase 3 Alpha (GSK3a) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAA630Ra01 | Polyclonal Antibody to Glycogen Synthase Kinase 3 Alpha (GSK3a) | WB; IHC; ICC; IP. |
MAA630Ra21 | Monoclonal Antibody to Glycogen Synthase Kinase 3 Alpha (GSK3a) | WB; IHC; ICC; IP. | |
Assay Kits | SEA630Ra | ELISA Kit for Glycogen Synthase Kinase 3 Alpha (GSK3a) | Enzyme-linked immunosorbent assay for Antigen Detection. |
- "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Potential role of glycogen synthase kinase-3 in skeletal muscle insulin resistance of type 2 diabetes."Diabetes 49:263-271(2000) [PubMed] [Europe PMC] [Abstract]
- "GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides."Nature 423:435-439(2003) [PubMed] [Europe PMC] [Abstract]
- "GSK3alpha exhibits beta-catenin and tau directed kinase activities that are modulated by Wnt."Eur. J. Neurosci. 24:3387-3392(2006) [PubMed] [Europe PMC] [Abstract]
- "Glycogen synthase kinase-3: properties, functions, and regulation."Chem. Rev. 101:2527-2540(2001) [PubMed] [Europe PMC] [Abstract]
- "The role of GSK3 in glucose homeostasis and the development of insulin resistance."Diabetes Res. Clin. Pract. 77:S49-S57(2007) [PubMed] [Europe PMC] [Abstract]
- "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
- "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
- "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
- "Glycogen synthase kinase 3: more than a namesake."Br. J. Pharmacol. 156:885-898(2009) [PubMed] [Europe PMC] [Abstract]
- "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
- "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
- "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
- "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
- "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]