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CCAAT/Enhancer Binding Protein Alpha (CEBPa)

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CEBP-A

CCAAT/Enhancer Binding Protein Alpha (CEBPa)
CCC A644
HGNC 1833
MGI 99480
PubMed 12351377
RGD 2326
UniProt P49715
Wiki CEBPA

CCAAT/enhancer binding protein (C/EBP), alpha is a bZIP transcription factor which can bind as a homodimer to certain promoters and enhancers. It can also form heterodimers with the related proteins CEBP-beta and CEBP-gamma. The encoded protein has been shown to bind to the promoter and modulate the expression of the gene encoding leptin, a protein that plays an important role in body weight homeostasis. Also, the encoded protein can interact with CDK2 and CDK4, thereby inhibiting these kinases and causing growth arrest in cultured cells. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA644Hu01 Recombinant CCAAT/Enhancer Binding Protein Alpha (CEBPa) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA644Hu01 Polyclonal Antibody to CCAAT/Enhancer Binding Protein Alpha (CEBPa) WB; IHC; ICC; IP.
MAA644Hu22 Monoclonal Antibody to CCAAT/Enhancer Binding Protein Alpha (CEBPa) WB; IHC; ICC; IP.
Assay Kits SEA644Hu ELISA Kit for CCAAT/Enhancer Binding Protein Alpha (CEBPa) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant CCAAT/Enhancer Binding Protein Alpha (CEBPa) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to CCAAT/Enhancer Binding Protein Alpha (CEBPa) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to CCAAT/Enhancer Binding Protein Alpha (CEBPa) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for CCAAT/Enhancer Binding Protein Alpha (CEBPa) CLIA Kit Customized Service Offer
n/a ELISA Kit for CCAAT/Enhancer Binding Protein Alpha (CEBPa) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA644Ra01 Recombinant CCAAT/Enhancer Binding Protein Alpha (CEBPa) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA644Ra01 Polyclonal Antibody to CCAAT/Enhancer Binding Protein Alpha (CEBPa) WB; IHC; ICC; IP.
MAA644Ra21 Monoclonal Antibody to CCAAT/Enhancer Binding Protein Alpha (CEBPa) WB
MAA644Ra22 Monoclonal Antibody to CCAAT/Enhancer Binding Protein Alpha (CEBPa) WB; IHC; ICC; IP.
MAA644Ra23 Monoclonal Antibody to CCAAT/Enhancer Binding Protein Alpha (CEBPa) WB; IHC; ICC; IP.
MAA644Ra24 Monoclonal Antibody to CCAAT/Enhancer Binding Protein Alpha (CEBPa) WB; IHC; ICC; IP.
Assay Kits SEA644Ra ELISA Kit for CCAAT/Enhancer Binding Protein Alpha (CEBPa) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Molecular cloning, sequence, and expression patterns of the human gene encoding CCAAT/enhancer binding protein alpha (C/EBP alpha)."Biochem. Biophys. Res. Commun. 215:106-113(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Transcription factor C/EBP-alpha: novel sites of expression and cloning of the human gene."Biol. Chem. Hoppe-Seyler 378:373-379(1997)
  3. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Interaction of hepatitis B viral X protein and CCAAT/enhancer-binding protein alpha synergistically activates the hepatitis B viral enhancer II/pregenomic promoter."J. Biol. Chem. 274:2858-2865(1999) [PubMed] [Europe PMC] [Abstract]
  6. "Ubinuclein, a novel nuclear protein interacting with cellular and viral transcription factors."J. Cell Biol. 148:1165-1176(2000) [PubMed] [Europe PMC] [Abstract]
  7. "Mutations of CEBPA in acute myeloid leukemia FAB types M1 and M2."Genes Chromosomes Cancer 37:72-78(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBP alpha growth inhibitory activity."Genes Dev. 18:912-925(2004) [PubMed] [Europe PMC] [Abstract]
  9. "The CCAAT enhancer-binding protein alpha (C/EBPalpha) requires a SWI/SNF complex for proliferation arrest."J. Biol. Chem. 279:7353-7358(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Mutation of CEBPA in familial acute myeloid leukemia."N. Engl. J. Med. 351:2403-2407(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Nucleolar retention of a translational C/EBPalpha isoform stimulates rDNA transcription and cell size."EMBO J. 29:897-909(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Repression of transcriptional activity of C/EBPalpha by E2F-dimerization partner complexes."Mol. Cell. Biol. 30:2293-2304(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia."Nat. Genet. 27:263-270(2001) [PubMed] [Europe PMC] [Abstract]