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Mothers Against Decapentaplegic Homolog 7 (Smad7)

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MADH7; MADH8; Mothers against DPP homolog 8

Mothers Against Decapentaplegic Homolog 7 (Smad7)
CCC A648
HGNC 6773
MGI 1100518
PubMed 12234288
RGD 69314
UniProt O15105
Wiki SMAD7
MAD proteins, originally defined in Drosophila, are essential components of the signaling pathways of the transforming growth factor-beta receptor family. Using a differential display approach in cultured endothelial cells subjected to multiple soluble and biomechanical stimuli, Topper et al. (1997) isolated a human endothelial cell cDNA encoding MADH7, which they called SMAD7.
The predicted 426-amino acid MADH7 protein lacks the C-terminal putative phosphorylation sites present in other MAD proteins, suggesting that it may be distinctly regulated. In situ hybridization and immunohistochemical analyses on human tissues showed that MADH7 is expressed predominantly in vascular endothelium.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA648Hu01 Recombinant Mothers Against Decapentaplegic Homolog 7 (Smad7) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA648Hu01 Polyclonal Antibody to Mothers Against Decapentaplegic Homolog 7 (Smad7) WB; IHC; ICC; IP.
MAA648Hu22 Monoclonal Antibody to Mothers Against Decapentaplegic Homolog 7 (Smad7) WB; IHC; ICC; IP.
Assay Kits SEA648Hu ELISA Kit for Mothers Against Decapentaplegic Homolog 7 (Smad7) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA648Mu01 Recombinant Mothers Against Decapentaplegic Homolog 7 (Smad7) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA648Mu01 Polyclonal Antibody to Mothers Against Decapentaplegic Homolog 7 (Smad7) WB; IHC; ICC; IP.
Assay Kits SEA648Mu ELISA Kit for Mothers Against Decapentaplegic Homolog 7 (Smad7) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA648Ra01 Recombinant Mothers Against Decapentaplegic Homolog 7 (Smad7) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA648Ra01 Polyclonal Antibody to Mothers Against Decapentaplegic Homolog 7 (Smad7) WB; IHC; ICC; IP.
MAA648Ra21 Monoclonal Antibody to Mothers Against Decapentaplegic Homolog 7 (Smad7) WB; IHC; ICC; IP.
Assay Kits SEA648Ra ELISA Kit for Mothers Against Decapentaplegic Homolog 7 (Smad7) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling."Cell 89:1165-1173(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Vascular MADs: two novel MAD-related genes selectively inducible by flow in human vascular endothelium."Proc. Natl. Acad. Sci. U.S.A. 94:9314-9319(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling."Nature 389:631-635(1997) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "DNA sequence and analysis of human chromosome 18." Nature 437:551-555(2005) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "TGF-beta signal transduction."Annu. Rev. Biochem. 67:753-791(1998) [PubMed] [Europe PMC] [Abstract]
  8. "Remarkable versatility of Smad proteins in the nucleus of transforming growth factor-beta activated cells."Cytokine Growth Factor Rev. 10:187-199(1999) [PubMed] [Europe PMC] [Abstract]
  9. "Roles of pathway-specific and inhibitory Smads in activin receptor signaling."Mol. Endocrinol. 13:15-23(1999) [PubMed] [Europe PMC] [Abstract]
  10. "The Smad pathway."Cytokine Growth Factor Rev. 11:5-13(2000) [PubMed] [Europe PMC] [Abstract]
  11. "TGF-beta signaling by Smad proteins."Cytokine Growth Factor Rev. 11:15-22(2000) [PubMed] [Europe PMC] [Abstract]
  12. "Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF-beta receptor for degradation."Mol. Cell 6:1365-1375(2000) [PubMed] [Europe PMC] [Abstract]
  13. "Promoting bone morphogenetic protein signaling through negative regulation of inhibitory Smads."EMBO J. 20:4132-4142(2001) [PubMed] [Europe PMC] [Abstract]
  14. "Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation."J. Biol. Chem. 276:12477-12480(2001) [PubMed] [Europe PMC] [Abstract]
  15. "Phosphorylation regulation of the interaction between Smad7 and activin type I receptor."FEBS Lett. 519:93-98(2002) [PubMed] [Europe PMC] [Abstract]
  16. "Control of Smad7 stability by competition between acetylation and ubiquitination."Mol. Cell 10:483-493(2002) [PubMed] [Europe PMC] [Abstract]
  17. "Arkadia amplifies TGF-beta superfamily signaling through degradation of Smad7."EMBO J. 22:6458-6470(2003) [PubMed] [Europe PMC] [Abstract]
  18. "GADD34-PP1c recruited by Smad7 dephosphorylates TGFbeta type I receptor."J. Cell Biol. 164:291-300(2004) [PubMed] [Europe PMC] [Abstract]
  19. "Jab1/CSN5, a component of the COP9 signalosome, regulates transforming growth factor beta signaling by binding to Smad7 and promoting its degradation."Mol. Cell. Biol. 24:2251-2262(2004) [PubMed] [Europe PMC] [Abstract]
  20. "Regulation of Smurf2 ubiquitin ligase activity by anchoring the E2 to the HECT domain."Mol. Cell 19:297-308(2005) [PubMed] [Europe PMC] [Abstract]
  21. "Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia."EMBO J. 25:1646-1658(2006) [PubMed] [Europe PMC] [Abstract]
  22. "3-Phosphoinositide-dependent PDK1 negatively regulates transforming growth factor-beta-induced signaling in a kinase-dependent manner through physical interaction with Smad proteins."J. Biol. Chem. 282:12272-12289(2007) [PubMed] [Europe PMC] [Abstract]
  23. "An expanded WW domain recognition motif revealed by the interaction between Smad7 and the E3 ubiquitin ligase Smurf2."J. Biol. Chem. 281:17069-17075(2006) [PubMed] [Europe PMC] [Abstract]
  24. "A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk." Nat. Genet. 39:1315-1317(2007) [PubMed] [Europe PMC] [Abstract]