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Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP)

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HABP1; GC1QBP; SF2p32; GC1Q-R; GC1qR; P32; Hyaluronan Binding Protein 1; Splicing Factor SF2-Associated Protein; ASF/SF2-associated p32

Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP)
CCC A651
HGNC 1243
MGI 1194505
PubMed 22451658
RGD 2230
UniProt Q07021

HABP1 is translocated to the nucleus upon mitogenic stimulation.Hyaluronic Acid (HA), also called hyaluronate or hyaluronan, is a mucopolysaccharide widely distributed throughout the body. HA is produced mainly by fibroblasts and other specialized connective tissue cells.HABP is hyaluronic acid binding protein. Detection of 34 kDa HABP in the serum-free supernatant culture medium of fibroblasts was further evident by immunoblot analysis, thus confirming the secretory nature of HABP and its occurrence in the extracellular matrix.HABP binding to C32 cells and erythrocytes was independent of peptide charge or peptide structure. HABP efficiently prevented the basic fibroblast growth factor/epidermal growth factor (bFGF/EGF)-dependent proliferation of human umbilical vein endothelial cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA651Hu01 Recombinant Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA651Hu01 Polyclonal Antibody to Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP) WB,IHC; FCM
MAA651Hu22 Monoclonal Antibody to Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP) WB; IHC; ICC; IP.
LAA651Hu71 Biotin-Linked Polyclonal Antibody to Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP) WB; IHC; ICC.
LAA651Hu81 FITC-Linked Polyclonal Antibody to Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP) WB; IHC; ICC; IF.
MAA651Hu21 Monoclonal Antibody to Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP) WB; ICC/IF
MAA651Hu23 Monoclonal Antibody to Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP) WB; IHC; ICC; IP.
MAA651Hu24 Monoclonal Antibody to Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP) WB; IHC; ICC; IP.
PAA651Hu02 Polyclonal Antibody to Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP) WB; IHC; ICC; IP.
MAA651Hu25 Monoclonal Antibody to Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP) WB; IHC; ICC; IP.
MAA651Hu27 Monoclonal Antibody to Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP) WB; IHC; ICC; IP.
PAA651Hu03 Polyclonal Antibody to Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP) FCM
Assay Kits SEA651Hu ELISA Kit for Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA651Mu01 Recombinant Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA651Mu01 Polyclonal Antibody to Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP) WB; IHC; ICC; IP.
LAA651Mu71 Biotin-Linked Polyclonal Antibody to Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP) WB; IHC; ICC.
LAA651Mu81 FITC-Linked Polyclonal Antibody to Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP) WB; IHC; ICC; IF.
Assay Kits n/a CLIA Kit for Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA651Ra01 Recombinant Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA651Ra01 Polyclonal Antibody to Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP) WB; IHC; ICC; IP.
LAA651Ra71 Biotin-Linked Polyclonal Antibody to Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP) WB; IHC; ICC.
LAA651Ra81 FITC-Linked Polyclonal Antibody to Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP) WB; IHC; ICC; IF.
Assay Kits n/a CLIA Kit for Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP) ELISA Kit Customized Service Offer

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA651Bo01 Recombinant Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA651Bo01 Polyclonal Antibody to Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP) ELISA Kit Customized Service Offer
  1. "Cloning and expression of a cDNA covering the complete coding region of the P32 subunit of human pre-mRNA splicing factor SF2."Gene 134:283-287(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Isolation, cDNA cloning, and overexpression of a 33-kD cell surface glycoprotein that binds to the globular 'heads' of C1q."J. Exp. Med. 179:1809-1821(1994) [PubMed] [Europe PMC] [Abstract]
  3. "The human gC1qR/p32 gene, C1qBP. Genomic organization and promoter analysis."J. Biol. Chem. 276:17069-17075(2001) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Functional expression of cloned human splicing factor SF2: homology to RNA-binding proteins, U1 70K, and Drosophila splicing regulators."Cell 66:383-394(1991) [PubMed] [Europe PMC] [Abstract]
  6. "Isolation and characterization of the kininogen-binding protein p33 from endothelial cells. Identity with the gC1q receptor."J. Biol. Chem. 271:13040-13047(1996) [PubMed] [Europe PMC] [Abstract]
  7. "Molecular cloning of human fibroblast hyaluronic acid-binding protein confirms its identity with P-32, a protein co-purified with splicing factor SF2. Hyaluronic acid-binding protein as P-32 protein, co-purified with splicing factor SF2."J. Biol. Chem. 271:2206-2212(1996) [PubMed] [Europe PMC] [Abstract]
  8. "The binding protein for globular heads of complement C1q, gC1qR. Functional expression and characterization as a novel vitronectin binding factor."J. Biol. Chem. 271:26739-26744(1996) [PubMed] [Europe PMC] [Abstract]
  9. "Identification of the zinc-dependent endothelial cell binding protein for high molecular weight kininogen and factor XII: identity with the receptor that binds to the globular 'heads' of C1q (gC1q-R)."Proc. Natl. Acad. Sci. U.S.A. 93:8552-8557(1996) [PubMed] [Europe PMC] [Abstract]
  10. "The C1q-binding cell membrane proteins cC1q-R and gC1q-R are released from activated cells: subcellular distribution and immunochemical characterization."Clin. Immunol. Immunopathol. 84:17-26(1997) [PubMed] [Europe PMC] [Abstract]
  11. "p32 protein, a splicing factor 2-associated protein, is localized in mitochondrial matrix and is functionally important in maintaining oxidative phosphorylation."J. Biol. Chem. 272:24363-24370(1997) [PubMed] [Europe PMC] [Abstract]
  12. "Evidence that the two C1q binding membrane proteins, gC1q-R and cC1q-R, associate to form a complex."J. Immunol. 159:1429-1436(1997) [PubMed] [Europe PMC] [Abstract]
  13. "C1q-mediated chemotaxis by human neutrophils: involvement of gClqR and G-protein signalling mechanisms."Biochem. J. 330:247-254(1998) [PubMed] [Europe PMC] [Abstract]
  14. "Cytokeratin 1 and gC1qR mediate high molecular weight kininogen binding to endothelial cells."Clin. Immunol. 92:246-255(1999) [PubMed] [Europe PMC] [Abstract]
  15. "The splicing factor-associated protein, p32, regulates RNA splicing by inhibiting ASF/SF2 RNA binding and phosphorylation."EMBO J. 18:1014-1024(1999) [PubMed] [Europe PMC] [Abstract]
  16. "gC1q-R/p32, a C1q-binding protein, is a receptor for the InlB invasion protein of Listeria monocytogenes."EMBO J. 19:1458-1466(2000) [PubMed] [Europe PMC] [Abstract]
  17. "Staphylococcus aureus protein A recognizes platelet gC1qR/p33: a novel mechanism for staphylococcal interactions with platelets."Infect. Immun. 68:2061-2068(2000) [PubMed] [Europe PMC] [Abstract]
  18. "Interaction between complement receptor gC1qR and hepatitis C virus core protein inhibits T-lymphocyte proliferation."J. Clin. Invest. 106:1239-1249(2000) [PubMed] [Europe PMC] [Abstract]
  19. "Rubella virus capsid associates with host cell protein p32 and localizes to mitochondria."J. Virol. 74:5569-5576(2000) [PubMed] [Europe PMC] [Abstract]
  20. "Retargeting of the mitochondrial protein p32/gC1Qr to a cytoplasmic compartment and the cell surface."J. Cell Sci. 114:2115-2123(2001) [PubMed] [Europe PMC] [Abstract]
  21. "Cooperation of C1q receptors and integrins in C1q-mediated endothelial cell adhesion and spreading."J. Immunol. 168:2441-2448(2002) [PubMed] [Europe PMC] [Abstract]
  22. "The N-terminal conserved domain of rubella virus capsid interacts with the C-terminal region of cellular p32 and overexpression of p32 enhances the viral infectivity."Virus Res. 85:151-161(2002) [PubMed] [Europe PMC] [Abstract]
  23. "Human p32 protein relieves a post-transcriptional block to HIV replication in murine cells."Nat. Cell Biol. 5:611-618(2003) [PubMed] [Europe PMC] [Abstract]
  24. ErratumNat. Cell Biol. 5:839-839(2003)
  25. "Activation-dependent surface expression of gC1qR/p33 on human blood platelets."Thromb. Haemost. 89:331-339(2003) [PubMed] [Europe PMC] [Abstract]
  26. "Physical and functional interaction between BH3-only protein Hrk and mitochondrial pore-forming protein p32."Cell Death Differ. 11:771-781(2004) [PubMed] [Europe PMC] [Abstract]
  27. "Human p32, interacts with B subunit of the CCAAT-binding factor, CBF/NF-Y, and inhibits CBF-mediated transcription activation in vitro."Nucleic Acids Res. 32:3632-3641(2004) [PubMed] [Europe PMC] [Abstract]
  28. "gC1q receptor ligation selectively down-regulates human IL-12 production through activation of the phosphoinositide 3-kinase pathway."J. Immunol. 175:4706-4714(2005) [PubMed] [Europe PMC] [Abstract]
  29. ErratumJ. Immunol. 178:3332-3332(2007)
  30. "CDC2L5, a Cdk-like kinase with RS domain, interacts with the ASF/SF2-associated protein p32 and affects splicing in vivo."J. Cell. Biochem. 99:890-904(2006) [PubMed] [Europe PMC] [Abstract]
  31. "Acetylated Tat regulates human immunodeficiency virus type 1 splicing through its interaction with the splicing regulator p32."J. Virol. 80:3189-3204(2006) [PubMed] [Europe PMC] [Abstract]
  32. "Chemotaxis of human monocyte-derived dendritic cells to complement component C1q is mediated by the receptors gC1qR and cC1qR."Mol. Immunol. 43:1402-1407(2006) [PubMed] [Europe PMC] [Abstract]
  33. "HCV core protein interaction with gC1q receptor inhibits Th1 differentiation of CD4+ T cells via suppression of dendritic cell IL-12 production."J. Leukoc. Biol. 82:1407-1419(2007) [PubMed] [Europe PMC] [Abstract]
  34. "Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction."Mol. Cell. Proteomics 6:1952-1967(2007) [PubMed] [Europe PMC] [Abstract]
  35. "The autophagic inducer smARF interacts with and is stabilized by the mitochondrial p32 protein."Oncogene 26:6677-6683(2007) [PubMed] [Europe PMC] [Abstract]
  36. "Human p32 is a novel FOXC1-interacting protein that regulates FOXC1 transcriptional activity in ocular cells."Invest. Ophthalmol. Vis. Sci. 49:5243-5249(2008) [PubMed] [Europe PMC] [Abstract]
  37. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  38. "Evidence for inhibitory interaction of hyaluronan-binding protein 1 (HABP1/p32/gC1qR) with Streptococcus pneumoniae hyaluronidase."J. Biol. Chem. 284:3897-3905(2009) [PubMed] [Europe PMC] [Abstract]
  39. "Inhibition of RIG-I and MDA5-dependent antiviral response by gC1qR at mitochondria."Proc. Natl. Acad. Sci. U.S.A. 106:1530-1535(2009) [PubMed] [Europe PMC] [Abstract]
  40. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  41. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  42. "An alternative role of C1q in cell migration and tissue remodeling: contribution to trophoblast invasion and placental development."J. Immunol. 185:4420-4429(2010) [PubMed] [Europe PMC] [Abstract]
  43. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  44. "Complement 1q-binding protein inhibits the mitochondrial permeability transition pore and protects against oxidative stress-induced death."Biochem. J. 433:119-125(2011) [PubMed] [Europe PMC] [Abstract]
  45. "Splicing factor 2-associated protein p32 participates in ribosome biogenesis by regulating the binding of Nop52 and fibrillarin to preribosome particles."Mol. Cell. Proteomics 10:0-0(2011) [PubMed] [Europe PMC] [Abstract]
  46. "Interaction of high-molecular-weight kininogen with endothelial cell binding proteins suPAR, gC1qR and cytokeratin 1 determined by surface plasmon resonance (BiaCore)."Thromb. Haemost. 105:1053-1059(2011) [PubMed] [Europe PMC] [Abstract]
  47. "DC-SIGN, C1q, and gC1qR form a trimolecular receptor complex on the surface of monocyte-derived immature dendritic cells."Blood 120:1228-1236(2012) [PubMed] [Europe PMC] [Abstract]
  48. "Binding of cellular p32 protein to the rubella virus P150 replicase protein via PxxPxR motifs."J. Gen. Virol. 93:807-816(2012) [PubMed] [Europe PMC] [Abstract]
  49. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  50. "Crystal structure of human p32, a doughnut-shaped acidic mitochondrial matrix protein."Proc. Natl. Acad. Sci. U.S.A. 96:3572-3577(1999) [PubMed] [Europe PMC] [Abstract]