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Bone Morphogenetic Protein 1 (BMP1)

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PCOLC; PCP; TLD; mTld; Procollagen C Proteinase; Mammalian tolloid protein

Bone Morphogenetic Protein 1 (BMP1)
CCC A653
HGNC 1067
MGI 88176
PubMed 16622848
RGD 620739
UniProt P13497
Wiki BMP1
The BMP1 locus encodes a protein that is capable of inducing formation of cartilage in vivo. Although other bone morphogenetic proteins are members of the TGF-beta superfamily, BMP1 encodes a protein that is not closely related to other known growth factors.
BMP1 protein and procollagen C proteinase (PCP), a secreted metalloprotease requiring calcium and needed for cartilage and bone formation, are identical. PCP or BMP1 protein cleaves the C-terminal propeptides of procollagen I, II, and III and its activity is increased by the procollagen C-endopeptidase enhancer protein. The BMP1 gene is expressed as alternatively spliced variants that share an N-terminal protease domain but differ in their C-terminal region.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA653Hu01 Recombinant Bone Morphogenetic Protein 1 (BMP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA653Hu01 Polyclonal Antibody to Bone Morphogenetic Protein 1 (BMP1) WB; IHC; ICC; IP.
MAA653Hu22 Monoclonal Antibody to Bone Morphogenetic Protein 1 (BMP1) WB; IHC; ICC; IP.
LAA653Hu81 FITC-Linked Polyclonal Antibody to Bone Morphogenetic Protein 1 (BMP1) WB; IHC; ICC; IF.
LAA653Hu71 Biotin-Linked Polyclonal Antibody to Bone Morphogenetic Protein 1 (BMP1) WB; IHC; ICC.
Assay Kits SEA653Hu ELISA Kit for Bone Morphogenetic Protein 1 (BMP1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA653Mu01 Recombinant Bone Morphogenetic Protein 1 (BMP1) Positive Control; Immunogen; SDS-PAGE; WB.
RPA653Mu02 Recombinant Bone Morphogenetic Protein 1 (BMP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA653Mu01 Polyclonal Antibody to Bone Morphogenetic Protein 1 (BMP1) WB; IHC; ICC; IP.
LAA653Mu71 Biotin-Linked Polyclonal Antibody to Bone Morphogenetic Protein 1 (BMP1) WB; IHC; ICC.
PAA653Mu02 Polyclonal Antibody to Bone Morphogenetic Protein 1 (BMP1) WB; IHC; ICC; IP.
Assay Kits SEA653Mu ELISA Kit for Bone Morphogenetic Protein 1 (BMP1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA653Ra01 Recombinant Bone Morphogenetic Protein 1 (BMP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA653Ra01 Polyclonal Antibody to Bone Morphogenetic Protein 1 (BMP1) WB; IHC; ICC; IP.
MAA653Ra21 Monoclonal Antibody to Bone Morphogenetic Protein 1 (BMP1) WB; IHC; ICC; IP.
Assay Kits SEA653Ra ELISA Kit for Bone Morphogenetic Protein 1 (BMP1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Bone Morphogenetic Protein 1 (BMP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Bone Morphogenetic Protein 1 (BMP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Bone Morphogenetic Protein 1 (BMP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Bone Morphogenetic Protein 1 (BMP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Bone Morphogenetic Protein 1 (BMP1) ELISA Kit Customized Service Offer
  1. "The C-proteinase that processes procollagens to fibrillar collagens is identical to the protein previously identified as bone morphogenic protein-1."Proc. Natl. Acad. Sci. U.S.A. 93:5127-5130(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Novel regulators of bone formation: molecular clones and activities."Science 242:1528-1534(1988) [PubMed] [Europe PMC] [Abstract]
  3. "Three alternatively spliced variants of the gene coding for the human bone morphogenetic protein-1."J. Mol. Med. 76:141-146(1998) [PubMed] [Europe PMC] [Abstract]
  4. "Bone morphogenetic protein-1 and a mammalian tolloid homologue (mTld) are encoded by alternatively spliced transcripts which are differentially expressed in some tissues."J. Biol. Chem. 269:32572-32578(1994) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Identification of amino acid residues in bone morphogenetic protein-1 important for procollagen C-proteinase activity."J. Biol. Chem. 276:26237-26242(2001) [PubMed] [Europe PMC] [Abstract]
  8. "Paired basic/Furin-like proprotein convertase cleavage of Pro-BMP-1 in the trans-Golgi network."J. Biol. Chem. 278:18478-18484(2003) [PubMed] [Europe PMC] [Abstract]
  9. "An unappreciated role for RNA surveillance."Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Structural basis for the substrate specificity of bone morphogenetic protein 1/tolloid-like metalloproteases."J. Mol. Biol. 384:228-239(2008) [PubMed] [Europe PMC] [Abstract]
  11. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Attenuated BMP1 function compromises osteogenesis, leading to bone fragility in humans and zebrafish." Am. J. Hum. Genet. 90:661-674(2012) [PubMed] [Europe PMC] [Abstract]
  13. "Identification of a mutation causing deficient BMP1/mTLD proteolytic activity in autosomal recessive osteogenesis imperfecta."Hum. Mutat. 33:343-350(2012) [PubMed] [Europe PMC] [Abstract]
  14. "Identification and in vivo functional characterization of novel compound heterozygous BMP1 variants in osteogenesis imperfecta."Hum. Mutat. 36:191-195(2015) [PubMed] [Europe PMC] [Abstract]