Glutathione S Transferase Mu 1 (GSTM1)

Strange et al. (1984) reported that GST1 is easily demonstrable in adult liver, kidney, adrenal and stomach but is only weakly expressed in skeletal and cardiac muscle and not at all in fetal liver, fibroblasts, erythrocytes, lymphocytes and platelets. GST2 is not detectable in the last 4 tissues but is found in many other tissues including fetal liver. GST3 (GSTP1) is found in every tissue except adult liver.By in situ hybridization, DeJong et al. (1988) mapped the GST1 gene to chromosome 1p31. Zhong et al. (1992) used oligonucleotide primers specific for intron 5 sequences in the GSTM1 gene to amplify a unique 718-bp fragment. They confirmed the assignment to 1p by analysis of DNA from a panel of somatic cell hybrids and refined the localization to 1p13 by linkage analysis in 3-generation CEPH families.