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Casein Kinase 1 Alpha 1 (CSNK1a1)

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CSNK1-A1; CK1; HLCDGP1

Casein Kinase 1 Alpha 1 (CSNK1a1)
CCC A661
HGNC 2451
MGI 1934950
PubMed 24616378
RGD 71098
UniProt P48729
Wiki CSNK1A1
Casein kinase activity was found to be present in most cell types and to be associated with multiple enzymes. The type 1 casein kinase family of related gene products are now given designations such as "casein kinase 1 alpha" and "casein kinase 1 epsilon". Casein kinase 1 alpha has been suggested to play a role in phosphorylation of Disheveled in the Wnt signaling pathway .Jia et al. (2004) showed that protein kinase A (PKA) and casein kinase I (CKI) regulate Smo cell surface accumulation and activity in response to hedgehog (Hh). Blocking PKA or CKI activity in the Drosophila wing disc prevented Hh-induced Smo accumulation and attenuated pathway activity, whereas increasing PKA activity promoted Smo accumulation and pathway activation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA661Hu01 Recombinant Casein Kinase 1 Alpha 1 (CSNK1a1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA661Hu01 Polyclonal Antibody to Casein Kinase 1 Alpha 1 (CSNK1a1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Casein Kinase 1 Alpha 1 (CSNK1a1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Casein Kinase 1 Alpha 1 (CSNK1a1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Casein Kinase 1 Alpha 1 (CSNK1a1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Casein Kinase 1 Alpha 1 (CSNK1a1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Casein Kinase 1 Alpha 1 (CSNK1a1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Casein Kinase 1 Alpha 1 (CSNK1a1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Casein Kinase 1 Alpha 1 (CSNK1a1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA661Ra01 Recombinant Casein Kinase 1 Alpha 1 (CSNK1a1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA661Ra01 Polyclonal Antibody to Casein Kinase 1 Alpha 1 (CSNK1a1) WB,IHC,ICC/IF
Assay Kits n/a CLIA Kit for Casein Kinase 1 Alpha 1 (CSNK1a1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Casein Kinase 1 Alpha 1 (CSNK1a1) ELISA Kit Customized Service Offer
  1. "Cloning and chromosomal localization of the gene coding for human protein kinase CK1."FEBS Lett. 349:307-312(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Isolation and characterization of human casein kinase I epsilon (CKI), a novel member of the CKI gene family."J. Biol. Chem. 270:14875-14883(1995) [PubMed] [Europe PMC] [Abstract]
  3. "Large-scale cDNA transfection screening for genes related to cancer development and progression." Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Cell cycle-dependent localization of casein kinase I to mitotic spindles."Proc. Natl. Acad. Sci. U.S.A. 89:9454-9458(1992) [PubMed] [Europe PMC] [Abstract]
  8. "Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism."Cell 108:837-847(2002) [PubMed] [Europe PMC] [Abstract]
  9. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  10. "CKIalpha is associated with and phosphorylates star-PAP and is also required for expression of select star-PAP target messenger RNAs."J. Biol. Chem. 283:12665-12673(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  17. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  18. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]