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Toll Like Receptor 2 (TLR2)

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CD282; TIL4; Toll/interleukin-1 receptor-like protein 4

Toll Like Receptor 2 (TLR2)
CCC A663
HGNC 11848
MGI 1346060
PubMed 15593098
RGD 735138
UniProt O60603
Wiki TLR_2

TLR-2 plays a role in the immune system. TLR-2 is a membrane protein, a receptor, which is expressed on the surface of certain cells and recognizes foreign substances and passes on appropriate signals to the cells of the immune system. TLR-2 is a membrane receptor found at the surface of immune system cells that recognises many bacterial, fungal, viral and endogenous substances. Phagocytosis of bound materials takes place in endosome/phagosome and a cellular activation, so that the elements of the innate immune system take over such as macrophages, PMN and dendritic cells tasks of the nonspecific immune defense, B1a and form MZB first anti-bodies and uses in the process the specific anti-body formation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA663Hu01 Recombinant Toll Like Receptor 2 (TLR2) Positive Control; Immunogen; SDS-PAGE; WB.
RPA663Hu02 Recombinant Toll Like Receptor 2 (TLR2) Positive Control; Immunogen; SDS-PAGE; WB.
RPA663Hu03 Recombinant Toll Like Receptor 2 (TLR2) Positive Control; Immunogen; SDS-PAGE; WB.
APA663Hu02 Active Toll Like Receptor 2 (TLR2) Cell culture; Activity Assays.
RPA663Hu04 Recombinant Toll Like Receptor 2 (TLR2) Positive Control; Immunogen; SDS-PAGE; WB.
APA663Hu04 Active Toll Like Receptor 2 (TLR2) Cell culture; Activity Assays.
Antibodies PAA663Hu01 Polyclonal Antibody to Toll Like Receptor 2 (TLR2) WB; IHC; ICC; IP.
PAA663Hu02 Polyclonal Antibody to Toll Like Receptor 2 (TLR2) WB; IHC; ICC; IP.
LAA663Hu71 Biotin-Linked Polyclonal Antibody to Toll Like Receptor 2 (TLR2) WB; IHC; ICC.
LAA663Hu81 FITC-Linked Polyclonal Antibody to Toll Like Receptor 2 (TLR2) WB; IHC; ICC; IF.
MAA663Hu21 Monoclonal Antibody to Toll Like Receptor 2 (TLR2) WB; IHC; ICC; IP.
MAA663Hu22 Monoclonal Antibody to Toll Like Receptor 2 (TLR2) WB; IHC; ICC; IP.
LAA663Hu72 Biotin-Linked Monoclonal Antibody to Toll Like Receptor 2 (TLR2) WB; IHC; ICC.
MAA663Hu23 Monoclonal Antibody to Toll Like Receptor 2 (TLR2) WB; IHC; ICC; IP.
PAA663Hu03 Polyclonal Antibody to Toll Like Receptor 2 (TLR2) WB; IHC; ICC; IP.
MAA663Hu24 Monoclonal Antibody to Toll Like Receptor 2 (TLR2) WB; IHC; ICC; IP.
MAA663Hu25 Monoclonal Antibody to Toll Like Receptor 2 (TLR2) WB; IHC; ICC; IP.
PAA663Hu04 Polyclonal Antibody to Toll Like Receptor 2 (TLR2) WB; IHC; ICC; IP.
Assay Kits SEA663Hu ELISA Kit for Toll Like Receptor 2 (TLR2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA663Mu01 Recombinant Toll Like Receptor 2 (TLR2) Positive Control; Immunogen; SDS-PAGE; WB.
RPA663Mu02 Recombinant Toll Like Receptor 2 (TLR2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA663Mu01 Polyclonal Antibody to Toll Like Receptor 2 (TLR2) WB; IHC; ICC; IP.
PAA663Mu02 Polyclonal Antibody to Toll Like Receptor 2 (TLR2) WB; IHC; ICC; IP.
Assay Kits SEA663Mu ELISA Kit for Toll Like Receptor 2 (TLR2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA663Ra01 Recombinant Toll Like Receptor 2 (TLR2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA663Ra01 Polyclonal Antibody to Toll Like Receptor 2 (TLR2) WB; IHC; ICC; IP.
MAA663Ra21 Monoclonal Antibody to Toll Like Receptor 2 (TLR2) WB; IHC; ICC; IP.
Assay Kits SEA663Ra ELISA Kit for Toll Like Receptor 2 (TLR2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Toll Like Receptor 2 (TLR2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Toll Like Receptor 2 (TLR2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Toll Like Receptor 2 (TLR2) Polyclonal Antibody Customized Service Offer
Assay Kits SEA663Bo ELISA Kit for Toll Like Receptor 2 (TLR2) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Cloning and characterization of two Toll/Interleukin-1 receptor-like genes TIL3 and TIL4: evidence for a multi-gene receptor family in humans."Blood 91:4020-4027(1998) [PubMed] [Europe PMC] [Abstract]
  2. "A family of human receptors structurally related to Drosophila Toll."Proc. Natl. Acad. Sci. U.S.A. 95:588-593(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling."Nature 395:284-288(1998) [PubMed] [Europe PMC] [Abstract]
  4. "Natural selection in the TLR-related genes in the course of primate evolution."Immunogenetics 60:727-735(2008) [PubMed] [Europe PMC] [Abstract]
  5. "The heterogeneous allelic repertoire of human Toll-Like receptor (TLR) genes."PLoS ONE 4:E7803-E7803(2009) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Cloning and sequencing of extracellular domain and its N-terminal and C-terminal fragments of Toll-like receptor 2."Di 4 Jun Yi Da Xue Xue Bao 23:1085-1089(2002)
  8. "Cell activation and apoptosis by bacterial lipoproteins through Toll-like receptor-2."Science 285:736-739(1999) [PubMed] [Europe PMC] [Abstract]
  9. "A novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling."J. Immunol. 169:6668-6672(2002) [PubMed] [Europe PMC] [Abstract]
  10. "Four N-linked glycosylation sites in human toll-like receptor 2 cooperate to direct efficient biosynthesis and secretion."J. Biol. Chem. 279:34589-34594(2004) [PubMed] [Europe PMC] [Abstract]
  11. "TMEM59 defines a novel ATG16L1-binding motif that promotes local activation of LC3."EMBO J. 32:566-582(2013) [PubMed] [Europe PMC] [Abstract]
  12. "Structural basis for signal transduction by the Toll/interleukin-1 receptor domains."Nature 408:111-115(2000) [PubMed] [Europe PMC] [Abstract]
  13. "Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide."Cell 130:1071-1082(2007) [PubMed] [Europe PMC] [Abstract]
  14. "Detection of Toll-like receptor 2 (TLR2) mutation in the lepromatous leprosy patients."FEMS Immunol. Med. Microbiol. 31:53-58(2001) [PubMed] [Europe PMC] [Abstract]
  15. "A Toll-like receptor 2 polymorphism that is associated with lepromatous leprosy is unable to mediate mycobacterial signaling."J. Immunol. 170:3451-3454(2003) [PubMed] [Europe PMC] [Abstract]
  16. "Functional characterization of naturally occurring genetic variants in the human TLR1-2-6 gene family."Hum. Mutat. 32:643-652(2011) [PubMed] [Europe PMC] [Abstract]