≡

Tachykinin Receptor 3 (TACR3)

[Edit]

NK3R; NK3-R; TAC3RL; Neurokinin Beta Receptor; Neurokinin B receptor

Tachykinin Receptor 3 (TACR3)
CCC A666
HGNC 11528
MGI 892968
PubMed 24376026
RGD 3810
UniProt P29371
Wiki TACR3
Tachykinin receptor 3, also known as TACR3, is a protein belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neurokinin 3, also referred to as neurokinin B.
Huang et al. (1992) isolated cDNA clones encoding the human neurokinin-3 receptor from human brain mRNA. The cloned neurokinin-3 receptor was expressed in COS cells and Xenopus oocytes, where peptide binding affinity and intracellular effector activation were determined. Neurokinin B was the most potent agonist.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tachykinin Receptor 3 (TACR3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tachykinin Receptor 3 (TACR3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tachykinin Receptor 3 (TACR3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tachykinin Receptor 3 (TACR3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tachykinin Receptor 3 (TACR3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA666Mu01 Recombinant Tachykinin Receptor 3 (TACR3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA666Mu01 Polyclonal Antibody to Tachykinin Receptor 3 (TACR3) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Tachykinin Receptor 3 (TACR3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tachykinin Receptor 3 (TACR3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tachykinin Receptor 3 (TACR3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tachykinin Receptor 3 (TACR3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tachykinin Receptor 3 (TACR3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tachykinin Receptor 3 (TACR3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tachykinin Receptor 3 (TACR3) ELISA Kit Customized Service Offer
  1. "cDNA sequence and heterologous expression of the human neurokinin-3 receptor."Biochem. Biophys. Res. Commun. 184:966-972(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular characterisation, expression and localisation of human neurokinin-3 receptor."FEBS Lett. 299:90-95(1992) [PubMed] [Europe PMC] [Abstract]
  3. "The primary structure and gene organization of human substance P and neuromedin K receptors."Eur. J. Biochem. 204:1025-1033(1992) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for Neurokinin B in the central control of reproduction."Nat. Genet. 41:354-358(2009) [PubMed] [Europe PMC] [Abstract]
  6. "Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism." Am. J. Hum. Genet. 92:725-743(2013) [PubMed] [Europe PMC] [Abstract]
  7. "The prevalence of CHD7 missense versus truncating mutations is higher in patients with Kallmann syndrome than in typical CHARGE patients." J. Clin. Endocrinol. Metab. 99:E2138-2143(2014) [PubMed] [Europe PMC] [Abstract]