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Kallikrein 11 (KLK11)

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TLSP; hK11; Hippostatin; Kallikrein-Related Peptidase 11; Serine protease 20; Trypsin-like protease

Kallikrein 11 (KLK11)
CCC A669
HGNC 6359
MGI 1929977
PubMed 15893744
RGD 1308690
UniProt Q9UBX7
Wiki KLK11

Kallikrein 11 is a member of the human kallikrein gene family. KLK11 is a secreted serine protease, highly expressed in hormonally regulated tissues, including the prostate and the ovary. KLK11 has two alternative splicing isoforms, known as the brain type and prostate type. Many members of the human kallikrein gene family are differentially expressed in cancer and a few have potential as diagnostic/prognostic markers. KLK11 may represent a diagnostic and prognostic biomarker for ovarian cancer. KLK11 expression in prostate, testis, trachea, pancreas, salivary gland, thyroid, parathyroid, lung, stomach, and adult and fetal skin. Weaker expression was detected in heart, mammary gland, uterus, colon, and small intestine, with little to no expression in other tissues examined

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA669Hu01 Recombinant Kallikrein 11 (KLK11) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA669Hu01 Polyclonal Antibody to Kallikrein 11 (KLK11) WB,IHC
MAA669Hu22 Monoclonal Antibody to Kallikrein 11 (KLK11) WB; IHC; ICC; IP.
Assay Kits SEA669Hu ELISA Kit for Kallikrein 11 (KLK11) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Kallikrein 11 (KLK11) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Kallikrein 11 (KLK11) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Kallikrein 11 (KLK11) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Kallikrein 11 (KLK11) CLIA Kit Customized Service Offer
n/a ELISA Kit for Kallikrein 11 (KLK11) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA669Ra01 Recombinant Kallikrein 11 (KLK11) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA669Ra01 Polyclonal Antibody to Kallikrein 11 (KLK11) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Kallikrein 11 (KLK11) CLIA Kit Customized Service Offer
n/a ELISA Kit for Kallikrein 11 (KLK11) ELISA Kit Customized Service Offer
  1. "cDNA cloning and expression of a novel serine protease, TLSP."Biochim. Biophys. Acta 1399:225-228(1998) [PubMed] [Europe PMC] [Abstract]
  2. "A novel isoform of a kallikrein-like protease, TLSP/hippostasin, (PRSS20), is expressed in the human brain and prostate."Biochem. Biophys. Res. Commun. 272:205-211(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Genomic organization, mapping, tissue expression, and hormonal regulation of trypsin-like serine protease (TLSP PRSS20), a new member of the human kallikrein gene family."Genomics 63:88-96(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region."Gene 257:119-130(2000) [PubMed] [Europe PMC] [Abstract]
  5. "Molecular cloning and expression of a variant form of hippostasin/KLK11 in prostate."Prostate 54:299-305(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Multiple promoters regulate tissue-specific alternative splicing of the human kallikrein gene, KLK11/hippostasin."FEBS J. 273:3678-3686(2006) [PubMed] [Europe PMC] [Abstract]
  7. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  8. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Purification and characterization of human kallikrein 11, a candidate prostate and ovarian cancer biomarker, from seminal plasma."Clin. Cancer Res. 12:742-750(2006) [PubMed] [Europe PMC] [Abstract]