Cluster Of Differentiation 14 (CD14)

[Edit]

Monocyte differentiation antigen CD14; Myeloid cell-specific leucine-rich glycoprotein

Cluster Of Differentiation 14 (CD14)

CD14 exists in two forms. It is either anchored into the membrane by a glycosylphosphatidylinositol tail (mCD14) or it appears in a soluble form (sCD14). Soluble CD14 appears either after shedding of mCD14 (48 KDa) or is directly secreted from intracellular vesicles (56 KDa).CD14 takes its name from its inclusion in the cluster of differentiation group of cell surface marker proteins. CD14 was the first described pattern recognition receptor.CD14 acts as a co-receptor (along with the Toll-like receptor TLR 4 and MD-2) for the detection of bacterial lipopolysaccharide (LPS). CD14 can only bind LPS in the presence of lipopolysaccharide-binding protein (LBP). Although LPS is considered its main ligand CD14 also recognizes other pathogen associated molecular patterns.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA685Hu01 Recombinant Cluster Of Differentiation 14 (CD14) Positive Control; Immunogen; SDS-PAGE; WB.
APA685Hu01 Active Cluster Of Differentiation 14 (CD14) Cell culture; Activity Assays.
EPA685Hu61 Eukaryotic Cluster Of Differentiation 14 (CD14) Positive Control; Immunogen; SDS-PAGE; WB.
RPA685Hu02 Recombinant Cluster Of Differentiation 14 (CD14) Positive Control; Immunogen; SDS-PAGE; WB.
EPA685Hu62 Eukaryotic Cluster Of Differentiation 14 (CD14) Positive Control; Immunogen; SDS-PAGE; WB.
EPA685Hu64 Eukaryotic Cluster Of Differentiation 14 (CD14) Positive Control; Immunogen; SDS-PAGE; WB.
APA685Hu61 Active Cluster Of Differentiation 14 (CD14) Cell culture; Activity Assays.
APA685Hu62 Active Cluster Of Differentiation 14 (CD14) Cell culture; Activity Assays.
Antibodies PAA685Hu01 Polyclonal Antibody to Cluster Of Differentiation 14 (CD14) WB; IHC; ICC; IP.
MAA685Hu22 Monoclonal Antibody to Cluster Of Differentiation 14 (CD14) WB; IHC; ICC; IP.
LAA685Hu71 Biotin-Linked Polyclonal Antibody to Cluster Of Differentiation 14 (CD14) WB; IHC; ICC.
PAA685Hu02 Polyclonal Antibody to Cluster Of Differentiation 14 (CD14) WB; IHC; ICC; IP.
MAA685Hu26 Monoclonal Antibody to Cluster Of Differentiation 14 (CD14) WB; IHC; ICC; IP.
MAA685Hu21 Monoclonal Antibody to Cluster Of Differentiation 14 (CD14) WB; IHC; ICC; IP.
MAA685Hu24 Monoclonal Antibody to Cluster Of Differentiation 14 (CD14) WB; IHC; ICC; IP.
MAA685Hu25 Monoclonal Antibody to Cluster Of Differentiation 14 (CD14) WB; IHC; ICC; IP.
PAA685Hu06 Polyclonal Antibody to Cluster Of Differentiation 14 (CD14) WB; IHC; ICC; IP.
MAA685Hu27 Monoclonal Antibody to Cluster Of Differentiation 14 (CD14) WB; IHC; ICC; IP.
MAA685Hu29 Monoclonal Antibody to Cluster Of Differentiation 14 (CD14) WB; IHC; ICC; IP.
MAA685Hu23 Monoclonal Antibody to Cluster Of Differentiation 14 (CD14) WB; IHC; ICC; IP.
Assay Kits SEA685Hu ELISA Kit for Cluster Of Differentiation 14 (CD14) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA685Mu01 Recombinant Cluster Of Differentiation 14 (CD14) Positive Control; Immunogen; SDS-PAGE; WB.
RPA685Mu02 Recombinant Cluster Of Differentiation 14 (CD14) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA685Mu01 Polyclonal Antibody to Cluster Of Differentiation 14 (CD14) WB; IHC; ICC; IP.
PAA685Mu02 Polyclonal Antibody to Cluster Of Differentiation 14 (CD14) WB; IHC; ICC; IP.
Assay Kits SEA685Mu ELISA Kit for Cluster Of Differentiation 14 (CD14) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA685Ra01 Recombinant Cluster Of Differentiation 14 (CD14) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA685Ra01 Polyclonal Antibody to Cluster Of Differentiation 14 (CD14) WB; IHC; ICC; IP.
LAA685Ra81 FITC-Linked Polyclonal Antibody to Cluster Of Differentiation 14 (CD14) WB; IHC; ICC; IF.
LAA685Ra71 Biotin-Linked Polyclonal Antibody to Cluster Of Differentiation 14 (CD14) WB; IHC; ICC.
MAA685Ra21 Monoclonal Antibody to Cluster Of Differentiation 14 (CD14) WB; IHC; ICC; IP.
Assay Kits SEA685Ra ELISA Kit for Cluster Of Differentiation 14 (CD14) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA685Po01 Recombinant Cluster Of Differentiation 14 (CD14) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA685Po01 Polyclonal Antibody to Cluster Of Differentiation 14 (CD14) WB; IHC; ICC; IP.
MAA685Po21 Monoclonal Antibody to Cluster Of Differentiation 14 (CD14) WB; IHC; ICC; IP.
Assay Kits SEA685Po ELISA Kit for Cluster Of Differentiation 14 (CD14) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "The monocyte differentiation antigen, CD14, is anchored to the cell membrane by a phosphatidylinositol linkage."J. Immunol. 141:547-552(1988) [PubMed] [Europe PMC] [Abstract]
  2. "Nucleotide sequence of the gene encoding the monocyte differentiation antigen, CD14."Nucleic Acids Res. 16:4173-4173(1988) [PubMed] [Europe PMC] [Abstract]
  3. "Mouse and human CD14 (myeloid cell-specific leucine-rich glycoprotein) primary structure deduced from cDNA clones."Biochim. Biophys. Acta 1008:213-222(1989) [PubMed] [Europe PMC] [Abstract]
  4. "Monocyte antigen CD14 is a phospholipid anchored membrane protein."Blood 73:284-289(1989) [PubMed] [Europe PMC] [Abstract]
  5. "Cloning and sequencing of human CD14 gene."Sheng Wu Hua Xue Yu Sheng Wu Wu Li Jin Zhan 25:377-378(1998)
  6. "Natural selection in the TLR-related genes in the course of primate evolution."Immunogenetics 60:727-735(2008) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Structural relationship between the soluble and membrane-bound forms of human monocyte surface glycoprotein CD14."Mol. Immunol. 26:657-662(1989) [PubMed] [Europe PMC] [Abstract]
  9. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Enrichment of glycopeptides for glycan structure and attachment site identification."Nat. Methods 6:809-811(2009) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  13. "The crystal structure of human soluble CD14 reveals a bent solenoid with a hydrophobic amino-terminal pocket."J. Immunol. 190:1304-1311(2013) [PubMed] [Europe PMC] [Abstract]