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Prostaglandin-H2 D-isomerase (PTGDS)

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PGD2S; PDS; PGDS2; Prostaglandin D2 Synthase, Brain; Lipocalin-Type Prostaglandin D Synthase; Cerebrin-28; Beta-trace protein; Glutathione-independent PGD synthase

Prostaglandin-H2 D-isomerase (PTGDS)
CCC A724
HGNC 9592
MGI 99261
PubMed 11703586
RGD 3433
UniProt P41222
Wiki PGD2S

PTGDS is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to prostaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This gene is preferentially expressed in brain. Studies with transgenic mice over-expressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement sleep. Furthermore, PTGDS and its product PGD2 are elevated in the bald-scalp areas of men with male pattern baldness. Prostaglandin D2 synthase is used clinically as a diagnostic marker for liquorrhea, that is, to check whether fluid leaking from the nose or ear contains cerebrospinal fluid.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA724Hu01 Recombinant Prostaglandin-H2 D-isomerase (PTGDS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA724Hu01 Polyclonal Antibody to Prostaglandin-H2 D-isomerase (PTGDS) WB; IHC; ICC; IP; FCM
MAA724Hu22 Monoclonal Antibody to Prostaglandin-H2 D-isomerase (PTGDS) WB
MAA724Hu21 Monoclonal Antibody to Prostaglandin-H2 D-isomerase (PTGDS) WB; IHC; ICC; IP.
MAA724Hu23 Monoclonal Antibody to Prostaglandin-H2 D-isomerase (PTGDS) WB; IHC; ICC; IP.
MAA724Hu24 Monoclonal Antibody to Prostaglandin-H2 D-isomerase (PTGDS) WB; IHC; ICC; IP.
LAA724Hu74 Biotin-Linked Monoclonal Antibody to Prostaglandin-H2 D-isomerase (PTGDS) WB; IHC; ICC.
Assay Kits SEA724Hu ELISA Kit for Prostaglandin-H2 D-isomerase (PTGDS) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Prostaglandin-H2 D-isomerase (PTGDS) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Prostaglandin-H2 D-isomerase (PTGDS) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Prostaglandin-H2 D-isomerase (PTGDS) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Prostaglandin-H2 D-isomerase (PTGDS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Prostaglandin-H2 D-isomerase (PTGDS) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Prostaglandin-H2 D-isomerase (PTGDS) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Prostaglandin-H2 D-isomerase (PTGDS) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Prostaglandin-H2 D-isomerase (PTGDS) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Prostaglandin-H2 D-isomerase (PTGDS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Prostaglandin-H2 D-isomerase (PTGDS) ELISA Kit Customized Service Offer
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  19. "Expression of lipocalin-type prostaglandin D synthase (beta-trace) in human heart and its accumulation in the coronary circulation of angina patients."Proc. Natl. Acad. Sci. U.S.A. 94:14689-14694(1997) [PubMed] [Europe PMC] [Abstract]
  20. "Expression of the beta-trace protein in human pachymeninx as revealed by in situ hybridization and immunocytochemistry."J. Neurosci. Res. 57:730-734(1999) [PubMed] [Europe PMC] [Abstract]
  21. "Lipocalin-type prostaglandin D synthase in essential hypertension."Hypertension 39:449-454(2002) [PubMed] [Europe PMC] [Abstract]
  22. "Beta-trace gene expression is regulated by a core promoter and a distal thyroid hormone response element."J. Biol. Chem. 272:14387-14393(1997) [PubMed] [Europe PMC] [Abstract]
  23. "Charge microheterogeneity of the beta-trace proteins (lipocalin-type prostaglandin D synthase) in the cerebrospinal fluid of patients with neurological disorders analyzed by capillary isoelectrofocusing."Electrophoresis 22:3433-3437(2001) [PubMed] [Europe PMC] [Abstract]
  24. "Urinary prostaglandin D synthase (beta-trace) excretion increases in the early stage of diabetes mellitus."Nephron 87:321-327(2001) [PubMed] [Europe PMC] [Abstract]
  25. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  26. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  27. "A strategy for precise and large scale identification of core fucosylated glycoproteins."Mol. Cell. Proteomics 8:913-923(2009) [PubMed] [Europe PMC] [Abstract]
  28. "Enrichment of glycopeptides for glycan structure and attachment site identification."Nat. Methods 6:809-811(2009) [PubMed] [Europe PMC] [Abstract]
  29. "Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD."Mol. Cell. Proteomics 0:0-0(2011) [PubMed] [Europe PMC] [Abstract]
  30. "LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins."J. Proteome Res. 12:573-584(2013) [PubMed] [Europe PMC] [Abstract]
  31. "Structure-function analysis of human l-prostaglandin D synthase bound with fatty acid molecules."FASEB J. 24:4668-4677(2010) [PubMed] [Europe PMC] [Abstract]
  32. "Crystal structure of the human lipocalin-type prostaglandin D synthase crystallised with the substrate analog 9,11-dideoxy-9alpha,11alpha- epoxymethanoprostaglandin f2alpha."Submitted (JAN-2010) to the PDB data bank