≡

Cyclooxygenase 1 (COX-1)

[Edit]

PTGS1; COX3; PCOX1; PGG/HS; PGHS1; PHS1; PTGHS; Prostaglandin Endoperoxide Synthase 1; Prostaglandin H2 Synthase 1; Prostaglandin G/H Synthase And Cyclooxygenase

Cyclooxygenase 1 (COX-1)
CCC A728
HGNC 9604
MGI 97797
PubMed 15159324
RGD 3439
UniProt P23219
Wiki PTGS1

There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. PTGS1, which regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Recent research has shown that the inhibition of COX-1 is the main reason why aspirin is effective at reducing cardiac events (as opposed to aspirin's anti-platelet aggregation effects).

PTGS1 is thought to be involved in cell-cell signaling and maintaining tissue homeostasis. Alternative splicing of this gene generates two transcript variants called COX-1 and COX-3. The expression of these two transcripts is differentially regulated by relevant cytokines and growth factors.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA728Hu01 Recombinant Cyclooxygenase 1 (COX-1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA728Hu01 Polyclonal Antibody to Cyclooxygenase 1 (COX-1) WB; IHC
MAA728Hu22 Monoclonal Antibody to Cyclooxygenase 1 (COX-1) WB; IHC; ICC; IP.
Assay Kits SEA728Hu ELISA Kit for Cyclooxygenase 1 (COX-1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA728Mu01 Recombinant Cyclooxygenase 1 (COX-1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA728Mu01 Polyclonal Antibody to Cyclooxygenase 1 (COX-1) WB; IHC; ICC; IP.
LAA728Mu51 APC-Linked Polyclonal Antibody to Cyclooxygenase 1 (COX-1) WB; IHC; ICC; IF.
Assay Kits n/a CLIA Kit for Cyclooxygenase 1 (COX-1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cyclooxygenase 1 (COX-1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA728Ra01 Recombinant Cyclooxygenase 1 (COX-1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA728Ra01 Polyclonal Antibody to Cyclooxygenase 1 (COX-1) WB; IHC; ICC; IP.
MAA728Ra21 Monoclonal Antibody to Cyclooxygenase 1 (COX-1) WB; IHC; ICC; IP.
Assay Kits SEA728Ra ELISA Kit for Cyclooxygenase 1 (COX-1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cyclooxygenase 1 (COX-1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cyclooxygenase 1 (COX-1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cyclooxygenase 1 (COX-1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cyclooxygenase 1 (COX-1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cyclooxygenase 1 (COX-1) ELISA Kit Customized Service Offer
  1. "Cloning of human gene encoding prostaglandin endoperoxide synthase and primary structure of the enzyme."Biochem. Biophys. Res. Commun. 165:888-894(1989) [PubMed] [Europe PMC] [Abstract]
  2. "Human platelet/erythroleukemia cell prostaglandin G/H synthase: cDNA cloning, expression, and gene chromosomal assignment."FASEB J. 5:2304-2312(1991) [PubMed] [Europe PMC] [Abstract]
  3. "Immunoaffinity purification and cDNA cloning of human platelet prostaglandin endoperoxide synthase (cyclooxygenase)."Biochem. Biophys. Res. Commun. 182:433-438(1992) [PubMed] [Europe PMC] [Abstract]
  4. "Alternative splicing of human prostaglandin G/H synthase mRNA and evidence of differential regulation of the resulting transcripts by transforming growth factor beta 1, interleukin 1 beta, and tumor necrosis factor alpha."J. Biol. Chem. 267:10816-10822(1992) [PubMed] [Europe PMC] [Abstract]
  5. "Cloning, expression, and functional characterization of human cyclooxygenase-1 splicing variants: evidence for intron 1 retention."J. Pharmacol. Exp. Ther. 315:1298-1305(2005) [PubMed] [Europe PMC] [Abstract]
  6. "Characterization of the human prostaglandin H synthase 1 gene (PTGS1): exclusion by genetic linkage analysis as a second modifier gene in familial thrombosis."Blood Coagul. Fibrinolysis 13:519-531(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  8. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Cyclooxygenases: structural, cellular, and molecular biology."Annu. Rev. Biochem. 69:145-182(2000) [PubMed] [Europe PMC] [Abstract]
  11. "Aspirin, cyclooxygenase inhibition and colorectal cancer."World J. Gastrointest. Pharmacol. Ther. 5:40-49(2014) [PubMed] [Europe PMC] [Abstract]
  12. "Arachidonate lipoxygenase (ALOX) and cyclooxygenase (COX) polymorphisms and colon cancer risk."Carcinogenesis 25:2467-2472(2004) [PubMed] [Europe PMC] [Abstract]