Bone Morphogenetic Protein Receptor 1B (BMPR1B)

In the chick embryo, it has been shown that BMPR1B is found in precartilaginous condensations.BMPR1B is the major transducer of signals in these condensations as demonstrated in experiments using constitutively active BMPR1B receptors. BMPR1B is a more effective trasducer of GDF5 than BMPR1A.Unlike BMPR1A null mice, which die at an early embryonic stage, BMPR1B null mice are viable.

The deduced protein contains an atypical N-terminal signal sequence, a small hydrophilic cysteine-rich ligand-binding domain, a transmembrane region, and an intracellular kinase domain. Mouse and human BMPR1B are highly conserved, and BMPR1B is most closely related to BMPR1A.