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Mannose Receptor C Type 2 (MRC2)

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CD280; ENDO180; CLEC13E; UPARAP; C-type lectin domain family 13 member E; Endocytic receptor 180; Macrophage mannose receptor 2; Urokinase receptor-associated protein

Mannose Receptor C Type 2 (MRC2)
CCC A733
HGNC 16875
MGI 107818
PubMed 22095946
RGD 1559436
UniProt Q9UBG0
Wiki MRC2

MRC2 is a recycling endocytic receptor that functions in cell motility and remodeling of the extracellular matrix by promoting cell migration and uptake of collagens for intracellular degradation (Wienke et al., 2007).

By sequencing clones obtained from a size-fractionated human brain cDNA library, Ishikawa et al. (1998) cloned MRC2, which they called KIAA0709. The deduced 1,479-amino acid protein was predicted to have a role in cell signaling. RT-PCR detected ubiquitous expression of MRC2, with highest levels in lung, heart, kidney, skeletal muscle, testis, and ovary.UPARAP formed a trimolecular complex of the surface of U937 or vascular smooth muscle cells following incubation with pro-urokinase. UPARAP bound specifically to collagen V , but exhibited little or no binding to other types of collagen.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA733Hu01 Recombinant Mannose Receptor C Type 2 (MRC2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA733Hu01 Polyclonal Antibody to Mannose Receptor C Type 2 (MRC2) WB; IHC; ICC; IP.
MAA733Hu22 Monoclonal Antibody to Mannose Receptor C Type 2 (MRC2) WB; IHC; ICC; IP.
Assay Kits SEA733Hu ELISA Kit for Mannose Receptor C Type 2 (MRC2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA733Mu01 Recombinant Mannose Receptor C Type 2 (MRC2) Positive Control; Immunogen; SDS-PAGE; WB.
RPA733Mu02 Recombinant Mannose Receptor C Type 2 (MRC2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA733Mu01 Polyclonal Antibody to Mannose Receptor C Type 2 (MRC2) WB; IHC; ICC; IP.
PAA733Mu02 Polyclonal Antibody to Mannose Receptor C Type 2 (MRC2) WB; IHC; ICC; IP.
Assay Kits SEA733Mu ELISA Kit for Mannose Receptor C Type 2 (MRC2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Mannose Receptor C Type 2 (MRC2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Mannose Receptor C Type 2 (MRC2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Mannose Receptor C Type 2 (MRC2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Mannose Receptor C Type 2 (MRC2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Mannose Receptor C Type 2 (MRC2) ELISA Kit Customized Service Offer
  1. "A urokinase receptor-associated protein with specific collagen binding properties."J. Biol. Chem. 275:1993-2002(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Endo180, an endocytic recycling glycoprotein related to the macrophage mannose receptor is expressed on fibroblasts, endothelial cells and macrophages and functions as a lectin receptor."J. Cell Sci. 113:1021-1032(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
  4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Characterization of a novel member of the macrophage mannose receptor type C lectin family."J. Biol. Chem. 271:21323-21330(1996) [PubMed] [Europe PMC] [Abstract]
  7. "The C-type lectin receptor Endo180 displays internalization and recycling properties distinct from other members of the mannose receptor family."J. Biol. Chem. 277:32320-32331(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Characterization of sugar binding by the mannose receptor family member, Endo180."J. Biol. Chem. 277:50469-50475(2002) [PubMed] [Europe PMC] [Abstract]
  9. "Identification and characterization of the endocytic transmembrane glycoprotein Endo180 as a novel collagen receptor."Mol. Biol. Cell 14:3592-3604(2003) [PubMed] [Europe PMC] [Abstract]
  10. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  11. "A strategy for precise and large scale identification of core fucosylated glycoproteins."Mol. Cell. Proteomics 8:913-923(2009) [PubMed] [Europe PMC] [Abstract]
  12. "In vivo identification of sumoylation sites by a signature tag and cysteine-targeted affinity purification."J. Biol. Chem. 285:19324-19329(2010) [PubMed] [Europe PMC] [Abstract]