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Protein C (PROC)

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PRO-C; VKDPC; PC; Vitamin K Dependent Protein C; Inactivator Of Coagulation Factors Va And VIIIa; Autoprothrombin IIA; Blood coagulation factor XIV; Activation peptide

Protein C (PROC)
CCC A734
HGNC 9451
MGI 97771
PubMed 1317308
RGD 3411
UniProt P04070
Wiki Protein_C

Protein C is a major physiological anticoagulant. It is a vitamin K-dependent serine protease enzyme (EC 3.4.21.69) that is activated by thrombin into activated protein C (APC). The activated form (with protein S and phospholipid as a cofactor) degrades Factor Va and Factor VIIIa. It should not be confused with C peptide or c-reactive protein or protein kinase C.The protein C pathway’s key enzyme, activated protein C, provides physiologic antithrombotic activity and exhibits both anti-inflammatory and anti-apoptotic activities. Its actions are related to development of thrombosis and ischemic stroke. The protein C pathway of the coagulation of the blood involves the influences of lipids and lipoproteins and the study of the strong epidemiologic association between hyperlipidemia and hypercoagulability.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA734Hu01 Recombinant Protein C (PROC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA734Hu01 Polyclonal Antibody to Protein C (PROC) WB; IHC; ICC; IP.
MAA734Hu22 Monoclonal Antibody to Protein C (PROC) WB; IHC; ICC; IP.
Assay Kits SEA734Hu ELISA Kit for Protein C (PROC) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA734Mu01 Recombinant Protein C (PROC) Positive Control; Immunogen; SDS-PAGE; WB.
RPA734Mu02 Recombinant Protein C (PROC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA734Mu01 Polyclonal Antibody to Protein C (PROC) WB; IHC; ICC; IP.
PAA734Mu02 Polyclonal Antibody to Protein C (PROC) WB; IHC; ICC; IP.
Assay Kits SEA734Mu ELISA Kit for Protein C (PROC) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA734Ra01 Recombinant Protein C (PROC) Positive Control; Immunogen; SDS-PAGE; WB.
RPA734Ra03 Recombinant Protein C (PROC) Positive Control; Immunogen; SDS-PAGE; WB.
RPA734Ra02 Recombinant Protein C (PROC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA734Ra01 Polyclonal Antibody to Protein C (PROC) WB; IHC; ICC; IP.
MAA734Ra21 Monoclonal Antibody to Protein C (PROC) WB; IHC; ICC; IP.
PAA734Ra02 Polyclonal Antibody to Protein C (PROC) WB; IHC; ICC; IP.
Assay Kits SEA734Ra ELISA Kit for Protein C (PROC) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein C (PROC) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein C (PROC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein C (PROC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein C (PROC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein C (PROC) ELISA Kit Customized Service Offer

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein C (PROC) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein C (PROC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein C (PROC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein C (PROC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein C (PROC) ELISA Kit Customized Service Offer
  1. "The structure and evolution of a 461 amino acid human protein C precursor and its messenger RNA, based upon the DNA sequence of cloned human liver cDNAs."Nucleic Acids Res. 13:5233-5247(1985) [PubMed] [Europe PMC] [Abstract]
  2. "The nucleotide sequence of the gene for human protein C."Proc. Natl. Acad. Sci. U.S.A. 82:4673-4677(1985) [PubMed] [Europe PMC] [Abstract]
  3. "Evolution and organization of the human protein C gene."Proc. Natl. Acad. Sci. U.S.A. 83:546-550(1986) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Protein C Osaka 10 with aberrant propeptide processing: loss of anticoagulant activity due to an amino acid substitution in the protein C precursor."Thromb. Haemost. 74:1003-1008(1995) [PubMed] [Europe PMC] [Abstract]
  8. "An abnormal protein C (protein C Yonago) with an amino acid substitution of Gly for Arg-15 caused by a single base mutation of C to G in codon 57 (CGG-->GGG). Deteriorated calcium-dependent conformation of the gamma-carboxyglutamic acid domain relevant to a thrombotic tendency."Int. J. Hematol. 57:9-14(1993) [PubMed] [Europe PMC] [Abstract]
  9. "Characterization of a cDNA coding for human protein C."Proc. Natl. Acad. Sci. U.S.A. 81:4766-4770(1984) [PubMed] [Europe PMC] [Abstract]
  10. "Homozygous type I protein C deficiency in two unrelated families exhibiting thrombophilia related to Ala136-->Pro or Arg286-->His mutations."Thromb. Haemost. 72:526-533(1994) [PubMed] [Europe PMC] [Abstract]
  11. "Beta protein C is not glycosylated at asparagine 329. The rate of translation may influence the frequency of usage at asparagine-X-cysteine sites."J. Biol. Chem. 265:11397-11404(1990) [PubMed] [Europe PMC] [Abstract]
  12. "O-linked fucose is present in the first epidermal growth factor domain of factor XII but not protein C."J. Biol. Chem. 267:5102-5107(1992) [PubMed] [Europe PMC] [Abstract]
  13. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  14. "Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD."Mol. Cell. Proteomics 0:0-0(2011) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  16. "Models of the serine protease domain of the human antithrombotic plasma factor activated protein C and its zymogen."Protein Sci. 3:588-599(1994) [PubMed] [Europe PMC] [Abstract]
  17. "The 2.8 A crystal structure of Gla-domainless activated protein C."EMBO J. 15:6822-6831(1996) [PubMed] [Europe PMC] [Abstract]
  18. "Protein C deficiency: a database of mutations."Thromb. Haemost. 69:77-84(1993) [PubMed] [Europe PMC] [Abstract]
  19. "Hereditary thrombophilia: identification of nonsense and missense mutations in the protein C gene."Proc. Natl. Acad. Sci. U.S.A. 84:2829-2832(1987) [PubMed] [Europe PMC] [Abstract]
  20. "Protein C London 1: recurrent mutation at Arg-169 (CGG-->TGG) in the protein C gene causing thrombosis."Nucleic Acids Res. 17:10513-10513(1989) [PubMed] [Europe PMC] [Abstract]
  21. "The spectrum of genetic defects in a panel of 40 Dutch families with symptomatic protein C deficiency type I: heterogeneity and founder effects."Blood 78:890-894(1991) [PubMed] [Europe PMC] [Abstract]
  22. "Protein CVermont: symptomatic type II protein C deficiency associated with two GLA domain mutations."Blood 79:1456-1465(1992) [PubMed] [Europe PMC] [Abstract]
  23. "Protein C deficiency Hong Kong 1 and 2: hereditary protein C deficiency caused by two mutant alleles, a 5-nucleotide deletion and a missense mutation."Blood 80:126-133(1992) [PubMed] [Europe PMC] [Abstract]
  24. "A novel homozygous missense mutation in the protein C (PROC) gene causing recurrent venous thrombosis."Hum. Genet. 89:683-684(1992) [PubMed] [Europe PMC] [Abstract]
  25. "Two different missense mutations at Arg 178 of the protein C (PROC) gene causing recurrent venous thrombosis."Hum. Genet. 89:685-686(1992) [PubMed] [Europe PMC] [Abstract]
  26. "Two novel mutations responsible for hereditary type I protein C deficiency: characterization by denaturing gradient gel electrophoresis."Hum. Mutat. 1:491-500(1992) [PubMed] [Europe PMC] [Abstract]
  27. "Homozygous protein C deficiency: identification of a novel missense mutation that causes impaired secretion of the mutant protein C."J. Lab. Clin. Med. 119:682-689(1992) [PubMed] [Europe PMC] [Abstract]
  28. "Five novel mutations located in exons III and IX of the protein C gene in patients presenting with defective protein C anticoagulant activity."Blood 82:159-168(1993) [PubMed] [Europe PMC] [Abstract]
  29. "Twelve novel and two recurrent mutations in 14 Austrian families with hereditary protein C deficiency."Blood Coagul. Fibrinolysis 4:273-280(1993) [PubMed] [Europe PMC] [Abstract]
  30. "A Gla domain mutation (Arg 15-->Trp) in the protein C (PROC) gene causing type 2 protein C deficiency and recurrent venous thrombosis."Blood Coagul. Fibrinolysis 4:345-347(1993) [PubMed] [Europe PMC] [Abstract]
  31. "Genetic mutations in ten unrelated American patients with symptomatic type 1 protein C deficiency."Blood Coagul. Fibrinolysis 4:791-796(1993) [PubMed] [Europe PMC] [Abstract]
  32. "Symptomatic type II protein C deficiency caused by a missense mutation (Gly 381-->Ser) in the substrate-binding pocket."Br. J. Haematol. 84:285-289(1993) [PubMed] [Europe PMC] [Abstract]
  33. "First de novo mutations in the protein C gene of two patients with type I deficiency: a missense mutation and a splice site deletion."Blood 84:2566-2570(1994) [PubMed] [Europe PMC] [Abstract]
  34. "A homozygous deletion/insertion mutation in the protein C (PROC) gene causing neonatal Purpura fulminans: prenatal diagnosis in an at-risk pregnancy."Blood Coagul. Fibrinolysis 5:647-649(1994) [PubMed] [Europe PMC] [Abstract]
  35. "A novel homozygous missense mutation (Val 325-->Ala) in the protein C gene causing neonatal purpura fulminans."Blood Coagul. Fibrinolysis 5:651-653(1994) [PubMed] [Europe PMC] [Abstract]
  36. "Six missense mutations associated with type I and type II protein C deficiency and implications obtained from molecular modelling."Blood Coagul. Fibrinolysis 5:687-696(1994) [PubMed] [Europe PMC] [Abstract]
  37. "Influence of six mutations of the protein C gene on the Gla domain conformation and calcium affinity."Thromb. Haemost. 71:748-754(1994) [PubMed] [Europe PMC] [Abstract]
  38. "Three novel mutations in the protein C (PROC) gene causing venous thrombosis."Blood Coagul. Fibrinolysis 6:138-140(1995) [PubMed] [Europe PMC] [Abstract]
  39. "Six different point mutations in seven Danish families with symptomatic protein C deficiency."Thromb. Haemost. 73:186-193(1995) [PubMed] [Europe PMC] [Abstract]
  40. "Two novel (R(-11)C; T394D) and two repeat missense mutations in the protein C gene associated with venous thrombosis in six kindreds."Hum. Mutat. 7:176-179(1996) [PubMed] [Europe PMC] [Abstract]
  41. "Type I protein C deficiency in French Canadians: evidence of a founder effect and association of specific protein C gene mutations with plasma protein C levels."Thromb. Haemost. 80:551-556(1998) [PubMed] [Europe PMC] [Abstract]
  42. "Molecular characterization of p.Asp77Gly and the novel p.Ala163Val and p.Ala163Glu mutations causing protein C deficiency."Thromb. Res. 135:718-726(2015) [PubMed] [Europe PMC] [Abstract]