Programmed Cell Death Protein 1 (PD1)

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CD279; PDCD1; SLEB2; HPD1P

Programmed Cell Death Protein 1 (PD1)

Programmed cell death 1, also known as PDCD1, is a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation.

In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure.

These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA751Hu01 Recombinant Programmed Cell Death Protein 1 (PD1) Positive Control; Immunogen; SDS-PAGE; WB.
APA751Hu01 Active Programmed Cell Death Protein 1 (PD1) Cell culture; Activity Assays.
RPA751Hu02 Recombinant Programmed Cell Death Protein 1 (PD1) Positive Control; Immunogen; SDS-PAGE; WB.
EPA751Hu61 Eukaryotic Programmed Cell Death Protein 1 (PD1) Positive Control; Immunogen; SDS-PAGE; WB.
APA751Hu61 Active Programmed Cell Death Protein 1 (PD1) Cell culture; Activity Assays.
APA751Hu02 Active Programmed Cell Death Protein 1 (PD1) Cell culture; Activity Assays.
Antibodies PAA751Hu01 Polyclonal Antibody to Programmed Cell Death Protein 1 (PD1) WB; IHC; ICC/IF
MAA751Hu21 Monoclonal Antibody to Programmed Cell Death Protein 1 (PD1) WB; IHC
MAA751Hu22 Monoclonal Antibody to Programmed Cell Death Protein 1 (PD1) WB; IHC; ICC; IP.
MAA751Hu23 Monoclonal Antibody to Programmed Cell Death Protein 1 (PD1) WB; IHC; ICC; IP.
MAA751Hu24 Monoclonal Antibody to Programmed Cell Death Protein 1 (PD1) WB; IHC; ICC; IP.
PAA751Hu02 Polyclonal Antibody to Programmed Cell Death Protein 1 (PD1) WB; IHC; ICC; IP.
MAA751Hu25 Monoclonal Antibody to Programmed Cell Death Protein 1 (PD1) WB; IHC; ICC; IP.
MAA751Hu27 Monoclonal Antibody to Programmed Cell Death Protein 1 (PD1) WB; IHC; ICC; IP.
MAA751Hu29 Monoclonal Antibody to Programmed Cell Death Protein 1 (PD1) WB; IHC; ICC; IP.
Assay Kits SEA751Hu ELISA Kit for Programmed Cell Death Protein 1 (PD1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA751Mu01 Recombinant Programmed Cell Death Protein 1 (PD1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Programmed Cell Death Protein 1 (PD1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Programmed Cell Death Protein 1 (PD1) Polyclonal Antibody Customized Service Offer
Assay Kits SEA751Mu ELISA Kit for Programmed Cell Death Protein 1 (PD1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA751Ra01 Recombinant Programmed Cell Death Protein 1 (PD1) Positive Control; Immunogen; SDS-PAGE; WB.
APA751Ra01 Active Programmed Cell Death Protein 1 (PD1) Cell culture; Activity Assays.
Antibodies PAA751Ra01 Polyclonal Antibody to Programmed Cell Death Protein 1 (PD1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Programmed Cell Death Protein 1 (PD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Programmed Cell Death Protein 1 (PD1) ELISA Kit Customized Service Offer

Organism species: Felis catus; Feline (Cat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins EPA751Fe61 Eukaryotic Programmed Cell Death Protein 1 (PD1) Positive Control; Immunogen; SDS-PAGE; WB.
APA751Fe61 Active Programmed Cell Death Protein 1 (PD1) Cell culture; Activity Assays.
Antibodies n/a Monoclonal Antibody to Programmed Cell Death Protein 1 (PD1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Programmed Cell Death Protein 1 (PD1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Programmed Cell Death Protein 1 (PD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Programmed Cell Death Protein 1 (PD1) ELISA Kit Customized Service Offer

Organism species: Canis familiaris; Canine (Dog)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA751Ca01 Recombinant Programmed Cell Death Protein 1 (PD1) Positive Control; Immunogen; SDS-PAGE; WB.
EPA751Ca62 Eukaryotic Programmed Cell Death Protein 1 (PD1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Programmed Cell Death Protein 1 (PD1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Programmed Cell Death Protein 1 (PD1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Programmed Cell Death Protein 1 (PD1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Programmed Cell Death Protein 1 (PD1) ELISA Kit Customized Service Offer
  1. "Structure and chromosomal localization of the human PD-1 gene (PDCD1)."Genomics 23:704-706(1994) [PubMed] [Europe PMC] [Abstract]
  2. "The human PD-1 gene: complete cDNA, genomic organization, and developmentally regulated expression in B cell progenitors."Gene 197:177-187(1997) [PubMed] [Europe PMC] [Abstract]
  3. ErratumGene 203:253-253(1997)
  4. "A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans." Nat. Genet. 32:666-669(2002) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The role of the PD-1 pathway in autoimmunity and peripheral tolerance."Ann. N. Y. Acad. Sci. 1217:45-59(2011) [PubMed] [Europe PMC] [Abstract]