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Programmed cell death 1, also known as PDCD1, is a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation.
In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure.
These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases.
Organism species: Homo sapiens (Human)
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA751Mu01 | Recombinant Programmed Cell Death Protein 1 (PD1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | n/a | Monoclonal Antibody to Programmed Cell Death Protein 1 (PD1) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Programmed Cell Death Protein 1 (PD1) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | SEA751Mu | ELISA Kit for Programmed Cell Death Protein 1 (PD1) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA751Ra01 | Recombinant Programmed Cell Death Protein 1 (PD1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| APA751Ra01 | Active Programmed Cell Death Protein 1 (PD1) | Cell culture; Activity Assays. | |
| Antibodies | PAA751Ra01 | Polyclonal Antibody to Programmed Cell Death Protein 1 (PD1) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Programmed Cell Death Protein 1 (PD1) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Programmed Cell Death Protein 1 (PD1) | ELISA Kit Customized Service Offer |
Organism species: Felis catus; Feline (Cat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | EPA751Fe61 | Eukaryotic Programmed Cell Death Protein 1 (PD1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| APA751Fe61 | Active Programmed Cell Death Protein 1 (PD1) | Cell culture; Activity Assays. | |
| Antibodies | n/a | Monoclonal Antibody to Programmed Cell Death Protein 1 (PD1) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Programmed Cell Death Protein 1 (PD1) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Programmed Cell Death Protein 1 (PD1) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Programmed Cell Death Protein 1 (PD1) | ELISA Kit Customized Service Offer |
Organism species: Canis familiaris; Canine (Dog)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA751Ca01 | Recombinant Programmed Cell Death Protein 1 (PD1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| EPA751Ca62 | Eukaryotic Programmed Cell Death Protein 1 (PD1) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | n/a | Monoclonal Antibody to Programmed Cell Death Protein 1 (PD1) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Programmed Cell Death Protein 1 (PD1) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Programmed Cell Death Protein 1 (PD1) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Programmed Cell Death Protein 1 (PD1) | ELISA Kit Customized Service Offer |
- "Structure and chromosomal localization of the human PD-1 gene (PDCD1)."Genomics 23:704-706(1994) [PubMed] [Europe PMC] [Abstract]
- "The human PD-1 gene: complete cDNA, genomic organization, and developmentally regulated expression in B cell progenitors."Gene 197:177-187(1997) [PubMed] [Europe PMC] [Abstract]
- ErratumGene 203:253-253(1997)
- "A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans." Nat. Genet. 32:666-669(2002) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "The role of the PD-1 pathway in autoimmunity and peripheral tolerance."Ann. N. Y. Acad. Sci. 1217:45-59(2011) [PubMed] [Europe PMC] [Abstract]