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Forkhead Box Protein C1 (FOXC1)

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FOX-C1; ARA; FKHL7; FREAC3; IGDA; IHG1; IRID1; Forkhead-related protein FKHL7; Forkhead-related transcription factor 3

Forkhead Box Protein C1 (FOXC1)
CCC A763
HGNC 3800
MGI 1347466
PubMed 15277473
RGD 1589718
UniProt Q12948
Wiki FOXC1

Forkhead box C1, also known as FOXC1, is a protein belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined; however, it has been shown to play a role in the regulation of embryonic and ocular development. Mutations in this gene cause various glaucoma phenotypes including primary congenital glaucoma, autosomal dominant iridogoniodysgenesis anomaly, and Axenfeld-Rieger anomaly. [provided by RefSeq]. Sequence Note: This RefSeq record was created from genomic sequence data because mRNA transcripts were not available for the full length of the gene. The extent of this transcript is supported by orthologous mouse data.
 

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Forkhead Box Protein C1 (FOXC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Forkhead Box Protein C1 (FOXC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Forkhead Box Protein C1 (FOXC1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Forkhead Box Protein C1 (FOXC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Forkhead Box Protein C1 (FOXC1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA763Mu01 Recombinant Forkhead Box Protein C1 (FOXC1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA763Mu01 Polyclonal Antibody to Forkhead Box Protein C1 (FOXC1) WB; IHC; ICC; IP.
LAA763Mu71 Biotin-Linked Polyclonal Antibody to Forkhead Box Protein C1 (FOXC1) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Forkhead Box Protein C1 (FOXC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Forkhead Box Protein C1 (FOXC1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Forkhead Box Protein C1 (FOXC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Forkhead Box Protein C1 (FOXC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Forkhead Box Protein C1 (FOXC1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Forkhead Box Protein C1 (FOXC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Forkhead Box Protein C1 (FOXC1) ELISA Kit Customized Service Offer
  1. "The forkhead transcription factor gene FKHL7 is responsible for glaucoma phenotypes which map to 6p25."Nat. Genet. 19:140-147(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Mutations of the forkhead/winged-helix gene, FKHL7, in patients with Axenfeld-Rieger anomaly."Am. J. Hum. Genet. 63:1316-1328(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Mutation spectrum of FOXC1 and clinical genetic heterogeneity of Axenfeld-Rieger anomaly in India."Mol. Vis. 9:43-48(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  5. "Drosophila forkhead homologues are expressed in a lineage-restricted manner in human hematopoietic cells."Blood 81:2854-2859(1993) [PubMed] [Europe PMC] [Abstract]
  6. "Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending."EMBO J. 13:5002-5012(1994) [PubMed] [Europe PMC] [Abstract]
  7. "FOXC1 is required for cell viability and resistance to oxidative stress in the eye through the transcriptional regulation of FOXO1A."Hum. Mol. Genet. 17:490-505(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Human p32 is a novel FOXC1-interacting protein that regulates FOXC1 transcriptional activity in ocular cells."Invest. Ophthalmol. Vis. Sci. 49:5243-5249(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  14. "A spectrum of FOXC1 mutations suggests gene dosage as a mechanism for developmental defects of the anterior chamber of the eye."Am. J. Hum. Genet. 68:364-372(2001) [PubMed] [Europe PMC] [Abstract]
  15. "A novel (Pro79Thr) mutation in the FKHL7 gene in a Japanese family with Axenfeld-Rieger syndrome."Am. J. Ophthalmol. 132:572-575(2001) [PubMed] [Europe PMC] [Abstract]
  16. "Screening for mutations of Axenfeld-Rieger syndrome caused by FOXC1 gene in Japanese patients."J. Glaucoma 10:477-482(2001) [PubMed] [Europe PMC] [Abstract]
  17. "Novel mutation in FOXC1 wing region causing Axenfeld-Rieger anomaly."Invest. Ophthalmol. Vis. Sci. 43:3613-3616(2002) [PubMed] [Europe PMC] [Abstract]
  18. "A family with Axenfeld-Rieger syndrome and Peters Anomaly caused by a point mutation (Phe112Ser) in the FOXC1 gene."Am. J. Ophthalmol. 135:368-375(2003) [PubMed] [Europe PMC] [Abstract]
  19. "Identification and analysis of a novel mutation in the FOXC1 forkhead domain."Invest. Ophthalmol. Vis. Sci. 44:4608-4612(2003) [PubMed] [Europe PMC] [Abstract]
  20. "Axenfeld-Rieger anomaly: a novel mutation in the forkhead box C1 (FOXC1) gene in a 4-generation family."Arch. Ophthalmol. 122:1527-1533(2004) [PubMed] [Europe PMC] [Abstract]
  21. "The wing 2 region of the FOXC1 forkhead domain is necessary for normal DNA-binding and transactivation functions."Invest. Ophthalmol. Vis. Sci. 45:2531-2538(2004) [PubMed] [Europe PMC] [Abstract]
  22. "Novel mutations of FOXC1 and PITX2 in patients with Axenfeld-Rieger malformations."Invest. Ophthalmol. Vis. Sci. 47:3846-3852(2006) [PubMed] [Europe PMC] [Abstract]
  23. ErratumInvest. Ophthalmol. Vis. Sci. 47:5162-5162(2006)
  24. "Analyses of a novel L130F missense mutation in FOXC1."Arch. Ophthalmol. 125:128-135(2007) [PubMed] [Europe PMC] [Abstract]