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Forkhead Box Protein O1 (FOXO1)

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FOX-O1; FKH1; FKHR; FOXO1A; Forkhead Homolog In Rhabdomyosarcoma

Forkhead Box Protein O1 (FOXO1)
CCC A764
HGNC 3819
MGI 1890077
PubMed 18590693
RGD 620283
UniProt Q12778
Wiki FOXO1

FOXO1 belongs to the forkhead family of transcription factors which are characterized by a distinct fork head domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Galili et al. (1993) isolated the chromosome 13 gene that is fused with PAX3. The rearrangement breakpoints occurred within an intron downstream of the paired box and homeodomain-encoding regions. Galili et al. (1993) identified the gene as a member of the forkhead domain family, which encodes transcription factors containing a conserved DNA-binding motif related to the Drosophila region-specific homeotic gene 'forkhead.' The distal half of the forkhead and the C-terminal region of the FKHR gene are involved in the chimeric transcript and fusion protein.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA764Hu01 Recombinant Forkhead Box Protein O1 (FOXO1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA764Hu01 Polyclonal Antibody to Forkhead Box Protein O1 (FOXO1) WB; IHC; IF; FCM
MAA764Hu22 Monoclonal Antibody to Forkhead Box Protein O1 (FOXO1) WB; IHC; ICC; IP.
Assay Kits SEA764Hu ELISA Kit for Forkhead Box Protein O1 (FOXO1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA764Mu01 Recombinant Forkhead Box Protein O1 (FOXO1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA764Mu01 Polyclonal Antibody to Forkhead Box Protein O1 (FOXO1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Forkhead Box Protein O1 (FOXO1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Forkhead Box Protein O1 (FOXO1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA764Ra01 Recombinant Forkhead Box Protein O1 (FOXO1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA764Ra01 Polyclonal Antibody to Forkhead Box Protein O1 (FOXO1) WB; IHC; ICC; IP.
MAA764Ra21 Monoclonal Antibody to Forkhead Box Protein O1 (FOXO1) WB; IHC; ICC; IP.
Assay Kits SEA764Ra ELISA Kit for Forkhead Box Protein O1 (FOXO1) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma."Nat. Genet. 5:230-235(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily."Genomics 47:187-199(1998) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 13." Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Fusion of PAX7 to FKHR by the variant t(1;13)(p36;q14) translocation in alveolar rhabdomyosarcoma."Cancer Res. 54:2869-2872(1994) [PubMed] [Europe PMC] [Abstract]
  6. "Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B."J. Biol. Chem. 274:17179-17183(1999) [PubMed] [Europe PMC] [Abstract]
  7. "Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence."J. Biol. Chem. 274:17184-17192(1999) [PubMed] [Europe PMC] [Abstract]
  8. "The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site."Biochem. J. 355:597-607(2001) [PubMed] [Europe PMC] [Abstract]
  9. "Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting."Biochem. J. 354:605-612(2001) [PubMed] [Europe PMC] [Abstract]
  10. "Two novel phosphorylation sites on FKHR that are critical for its nuclear exclusion."EMBO J. 21:2263-2271(2002) [PubMed] [Europe PMC] [Abstract]
  11. "Phosphorylation of serine 256 suppresses transactivation by FKHR (FOXO1) by multiple mechanisms. Direct and indirect effects on nuclear/cytoplasmic shuttling and DNA binding."J. Biol. Chem. 277:45276-45284(2002) [PubMed] [Europe PMC] [Abstract]
  12. "Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity."Proc. Natl. Acad. Sci. U.S.A. 101:10042-10047(2004) [PubMed] [Europe PMC] [Abstract]
  13. "The coactivator p300 directly acetylates the forkhead transcription factor Foxo1 and stimulates Foxo1-induced transcription."Mol. Endocrinol. 19:2283-2298(2005) [PubMed] [Europe PMC] [Abstract]
  14. "Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation."Proc. Natl. Acad. Sci. U.S.A. 102:1649-1654(2005) [PubMed] [Europe PMC] [Abstract]
  15. "Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt."Mol. Cell 32:221-231(2008) [PubMed] [Europe PMC] [Abstract]
  16. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  17. "Activation of FOXO1 by Cdk1 in cycling cells and postmitotic neurons."Science 319:1665-1668(2008) [PubMed] [Europe PMC] [Abstract]
  18. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  19. "Regulation of neuronal cell death by MST1-FOXO1 signaling."J. Biol. Chem. 284:11285-11292(2009) [PubMed] [Europe PMC] [Abstract]
  20. "Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity."Nat. Cell Biol. 12:665-675(2010) [PubMed] [Europe PMC] [Abstract]
  21. "KRIT1 regulates the homeostasis of intracellular reactive oxygen species."PLoS ONE 5:E11786-E11786(2010) [PubMed] [Europe PMC] [Abstract]
  22. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  23. "Hippo/Mst1 stimulates transcription of the proapoptotic mediator NOXA in a FoxO1-dependent manner."Cancer Res. 71:946-954(2011) [PubMed] [Europe PMC] [Abstract]
  24. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  25. "Structural basis for DNA recognition by FoxO1 and its regulation by posttranslational modification."Structure 16:1407-1416(2008) [PubMed] [Europe PMC] [Abstract]