≡

Forkhead Box Protein P1 (FOXP1)

[Edit]

FOX-P1; 12CC4; QRF1; HFKH1B; Fork Head-Related Protein Like B; Glutamine-Rich Factor 1; PAX5/FOXP1 Fusion Protein

Forkhead Box Protein P1 (FOXP1)
CCC A765
HGNC 3823
MGI 1914004
PubMed 20848658
RGD 1308669
UniProt Q9H334
Wiki FOXP1

FOXP1 ("forkhead box P1") is a gene that is necessary for the proper development of the brain and lung in mammals. It is a member of the large FOX family of transcription factors.

This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family.Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA765Hu01 Recombinant Forkhead Box Protein P1 (FOXP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA765Hu01 Polyclonal Antibody to Forkhead Box Protein P1 (FOXP1) WB; IHC
MAA765Hu21 Monoclonal Antibody to Forkhead Box Protein P1 (FOXP1) WB; IHC; ICC; IP.
MAA765Hu22 Monoclonal Antibody to Forkhead Box Protein P1 (FOXP1) WB
MAA765Hu23 Monoclonal Antibody to Forkhead Box Protein P1 (FOXP1) WB
Assay Kits SEA765Hu ELISA Kit for Forkhead Box Protein P1 (FOXP1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA765Mu01 Recombinant Forkhead Box Protein P1 (FOXP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA765Mu01 Polyclonal Antibody to Forkhead Box Protein P1 (FOXP1) WB; IHC; ICC; IP.
Assay Kits SEA765Mu ELISA Kit for Forkhead Box Protein P1 (FOXP1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Forkhead Box Protein P1 (FOXP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Forkhead Box Protein P1 (FOXP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Forkhead Box Protein P1 (FOXP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Forkhead Box Protein P1 (FOXP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Forkhead Box Protein P1 (FOXP1) ELISA Kit Customized Service Offer
  1. "The FOXP1 winged helix transcription factor is a novel candidate tumor suppressor gene on chromosome 3p."Cancer Res. 61:8820-8829(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia."Nature 446:758-764(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
  7. "Integrin engagement regulates monocyte differentiation through the forkhead transcription factor Foxp1."J. Clin. Invest. 114:408-418(2004) [PubMed] [Europe PMC] [Abstract]
  8. "FOXP1 is an androgen-responsive transcription factor that negatively regulates androgen receptor signaling in prostate cancer cells."Biochem. Biophys. Res. Commun. 374:388-393(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Down-regulation of the forkhead transcription factor Foxp1 is required for monocyte differentiation and macrophage function."Blood 112:4699-4711(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Cooperative regulation in development by SMRT and FOXP1."Genes Dev. 22:740-745(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  12. "De novo mutations in FOXP1 in cases with intellectual disability, autism, and language impairment."Am. J. Hum. Genet. 87:671-678(2010) [PubMed] [Europe PMC] [Abstract]
  13. "An alternative splicing switch regulates embryonic stem cell pluripotency and reprogramming."Cell 147:132-146(2011) [PubMed] [Europe PMC] [Abstract]
  14. "FoxP1 stimulates angiogenesis by repressing the inhibitory guidance protein semaphorin 5B in endothelial cells."PLoS ONE 8:E70873-E70873(2013) [PubMed] [Europe PMC] [Abstract]
  15. "FOXP1 directly represses transcription of pro-apoptotic genes and cooperates with NF-kappaB to promote survival of human B-cells."Blood 124:3431-3440(2014) [PubMed] [Europe PMC] [Abstract]
  16. "Transcriptional Regulation by FOXP1, FOXP2, and FOXP4 Dimerization."J. Mol. Neurosci. 55:437-448(2015) [PubMed] [Europe PMC] [Abstract]
  17. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  18. "Solution structure and backbone dynamics of the DNA-binding domain of FOXP1: insight into its domain swapping and DNA binding."Protein Sci. 20:908-924(2011) [PubMed] [Europe PMC] [Abstract]
  19. "Assessing the impact of FOXP1 mutations on developmental verbal dyspraxia."Eur. J. Hum. Genet. 17:1354-1358(2009) [PubMed] [Europe PMC] [Abstract]
  20. "Identification of FOXP1 deletions in three unrelated patients with mental retardation and significant speech and language deficits." Hum. Mutat. 31:E1851-E1860(2010) [PubMed] [Europe PMC] [Abstract]