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Forkhead Box Protein M1 (FOXM1)

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FKHL16; FOXM1B; HFH11; HNF3; INS1; MPHOSPH2; MPP2; PIG29; Trident; M-Phase Phosphoprotein 2; HNF-3/fork-head homolog 11; Winged-helix factor from INS-1 cells

Forkhead Box Protein M1 (FOXM1)
CCC A767
HGNC 3818
MGI 1347487
PubMed 19513552
RGD 61807
UniProt Q08050
Wiki FOXM1

Forkhead box protein M1 is a member of the FOX family of transcription factors.FOXM1 is known to play a key role in cell cycle progression where endogenous FOXM1 expression peaks at S and G2/M phases.

FOXM1-null mouse embryos were neonatal lethal as a result of the development of polyploid cardiomyocytes and hepatocytes, highlighting the role of FOXM1 in mitotic division. More recently a study using transgenic/knockout mouse embryonic fibroblasts and human osteosarcoma cells (U2OS) has shown that FOXM1, regulates expression of a large array of G2/M-specific genes, such as Plk1, cyclin B2, Nek2 and CENPF, and plays an important role in maintenance of chromosomal segregation and genomic stability

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Forkhead Box Protein M1 (FOXM1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Forkhead Box Protein M1 (FOXM1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Forkhead Box Protein M1 (FOXM1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Forkhead Box Protein M1 (FOXM1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Forkhead Box Protein M1 (FOXM1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA767Mu01 Recombinant Forkhead Box Protein M1 (FOXM1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Forkhead Box Protein M1 (FOXM1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Forkhead Box Protein M1 (FOXM1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Forkhead Box Protein M1 (FOXM1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Forkhead Box Protein M1 (FOXM1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA767Ra01 Recombinant Forkhead Box Protein M1 (FOXM1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA767Ra01 Polyclonal Antibody to Forkhead Box Protein M1 (FOXM1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Forkhead Box Protein M1 (FOXM1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Forkhead Box Protein M1 (FOXM1) ELISA Kit Customized Service Offer
  1. "Hepatocyte nuclear factor 3/fork head homolog 11 is expressed in proliferating epithelial and mesenchymal cells of embryonic and adult tissues."Mol. Cell. Biol. 17:1626-1641(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular analysis of a novel winged helix protein, WIN. Expression pattern, DNA binding property, and alternative splicing within the DNA binding domain."J. Biol. Chem. 272:19827-19836(1997) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Cloning of cDNAs for M-phase phosphoproteins recognized by the MPM2 monoclonal antibody and determination of the phosphorylated epitope."Proc. Natl. Acad. Sci. U.S.A. 91:714-718(1994) [PubMed] [Europe PMC] [Abstract]
  5. "Chk2 mediates stabilization of the FoxM1 transcription factor to stimulate expression of DNA repair genes."Mol. Cell. Biol. 27:1007-1016(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progression."Nat. Cell Biol. 10:1076-1082(2008) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  9. "Structure of the FoxM1 DNA-recognition domain bound to a promoter sequence."Nucleic Acids Res. 38:4527-4538(2010) [PubMed] [Europe PMC] [Abstract]