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Lipase, Hepatic (LIPC)

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HL; HTGL; Hepatic Lipase; Hepatic triacylglycerol lipase; Lipase member C

Lipase, Hepatic (LIPC)
CCC A769
HGNC 6619
MGI 96216
PubMed 8485124
RGD 3009
UniProt P11150
Wiki LIPC

  • Hepatic lipase is a form of lipase. It is expressed in the liver and adrenal glands.One of the principal functions of hepatic lipase is to convert IDL to LDL.LIPC encodes hepatic triglyceride lipase, which is expressed in liver. LIPC has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake.

  • Hepatic lipase deficiency is a rare, autosomal recessive disorder that results in elevated high density lipoprotein (HDL) cholesterol due to a mutation in the hepatic lipase gene. Clinical features are not well understood and there are no characteristic xanthomas. There is an association with a delay in atherosclerosis in an animal model.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA769Hu01 Recombinant Lipase, Hepatic (LIPC) Positive Control; Immunogen; SDS-PAGE; WB.
RPA769Hu02 Recombinant Lipase, Hepatic (LIPC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA769Hu01 Polyclonal Antibody to Lipase, Hepatic (LIPC) WB; ICC; IHC-P; IHC-F; ELISA.
MAA769Hu22 Monoclonal Antibody to Lipase, Hepatic (LIPC) WB; IHC; ICC; IP.
LAA769Hu71 Biotin-Linked Polyclonal Antibody to Lipase, Hepatic (LIPC) WB; IHC; ICC.
PAA769Hu02 Polyclonal Antibody to Lipase, Hepatic (LIPC) WB; ICC; IHC-P; IHC-F; ELISA.
Assay Kits SEA769Hu ELISA Kit for Lipase, Hepatic (LIPC) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA769Mu01 Recombinant Lipase, Hepatic (LIPC) Positive Control; Immunogen; SDS-PAGE; WB.
RPA769Mu02 Recombinant Lipase, Hepatic (LIPC) Positive Control; Immunogen; SDS-PAGE; WB.
RPA769Mu03 Recombinant Lipase, Hepatic (LIPC) Positive Control; Immunogen; SDS-PAGE; WB.
RPA769Mu04 Recombinant Lipase, Hepatic (LIPC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA769Mu01 Polyclonal Antibody to Lipase, Hepatic (LIPC) WB; IHC; ICC; IP.
LAA769Mu81 FITC-Linked Polyclonal Antibody to Lipase, Hepatic (LIPC) WB; IHC; ICC; IF.
LAA769Mu71 Biotin-Linked Polyclonal Antibody to Lipase, Hepatic (LIPC) WB; IHC; ICC.
PAA769Mu02 Polyclonal Antibody to Lipase, Hepatic (LIPC) WB; IHC; ICC; IP.
Assay Kits SEA769Mu ELISA Kit for Lipase, Hepatic (LIPC) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA769Ra01 Recombinant Lipase, Hepatic (LIPC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA769Ra01 Polyclonal Antibody to Lipase, Hepatic (LIPC) WB; IHC; ICC; IP.
LAA769Ra81 FITC-Linked Polyclonal Antibody to Lipase, Hepatic (LIPC) WB; IHC; ICC; IF.
LAA769Ra71 Biotin-Linked Polyclonal Antibody to Lipase, Hepatic (LIPC) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Lipase, Hepatic (LIPC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Lipase, Hepatic (LIPC) ELISA Kit Customized Service Offer

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA769Po01 Recombinant Lipase, Hepatic (LIPC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA769Po01 Polyclonal Antibody to Lipase, Hepatic (LIPC) WB; IHC; ICC; IP.
LAA769Po81 FITC-Linked Polyclonal Antibody to Lipase, Hepatic (LIPC) WB; IHC; ICC; IF.
LAA769Po71 Biotin-Linked Polyclonal Antibody to Lipase, Hepatic (LIPC) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Lipase, Hepatic (LIPC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Lipase, Hepatic (LIPC) ELISA Kit Customized Service Offer
  1. "Human hepatic triglyceride lipase: cDNA cloning, amino acid sequence and expression in a cultured cell line."Differentiation 35:45-52(1987) [PubMed] [Europe PMC] [Abstract]
  2. "Human hepatic lipase. Cloned cDNA sequence, restriction fragment length polymorphisms, chromosomal localization, and evolutionary relationships with lipoprotein lipase and pancreatic lipase."J. Biol. Chem. 263:1107-1110(1988) [PubMed] [Europe PMC] [Abstract]
  3. "Isolation and cDNA sequence of human postheparin plasma hepatic triglyceride lipase."J. Biol. Chem. 263:10907-10914(1988) [PubMed] [Europe PMC] [Abstract]
  4. "Structure of the human hepatic triglyceride lipase gene."Biochemistry 28:8966-8971(1989) [PubMed] [Europe PMC] [Abstract]
  5. "Isolation and characterization of the human hepatic lipase gene."J. Biol. Chem. 265:6552-6555(1990) [PubMed] [Europe PMC] [Abstract]
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Analysis of the DNA sequence and duplication history of human chromosome 15." Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "18 bp insertion/duplication with internal missense mutation in human hepatic lipase gene exon 3."Hum. Mutat. 12:216-216(1998) [PubMed] [Europe PMC] [Abstract]
  10. "Identification of a BstNI polymorphism in exon 9 of the human hepatic triglyceride lipase gene."Mol. Cell. Probes 10:313-314(1996) [PubMed] [Europe PMC] [Abstract]
  11. "The G-250A promoter polymorphism of the hepatic lipase gene predicts the conversion from impaired glucose tolerance to type 2 diabetes mellitus: the Finnish diabetes prevention study."J. Clin. Endocrinol. Metab. 89:2019-2023(2004) [PubMed] [Europe PMC] [Abstract]
  12. "The -250G>A promoter variant in hepatic lipase associates with elevated fasting serum high-density lipoprotein cholesterol modulated by interaction with physical activity in a study of 16,156 Danish subjects."J. Clin. Endocrinol. Metab. 93:2294-2299(2008) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  14. "Human hepatic lipase mutations and polymorphisms."Hum. Mutat. 1:320-324(1992) [PubMed] [Europe PMC] [Abstract]
  15. "Genetic variants affecting human lipoprotein and hepatic lipases."Curr. Opin. Lipidol. 2:104-109(1991)
  16. "Characterization of single-nucleotide polymorphisms in coding regions of human genes."Nat. Genet. 22:231-238(1999) [PubMed] [Europe PMC] [Abstract]
  17. ErratumNat. Genet. 23:373-373(1999)
  18. "Association of extreme blood lipid profile phenotypic variation with 11 reverse cholesterol transport genes and 10 non-genetic cardiovascular disease risk factors."Hum. Mol. Genet. 12:2733-2743(2003) [PubMed] [Europe PMC] [Abstract]