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Complement Factor P (CFP)

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CF-P; PFC; Properdin

Complement Factor P (CFP)
CCC A783
HGNC 8864
MGI 97545
PubMed 20941861
RGD 1594557
UniProt P27918
Wiki Properdin

Properdin or factor P is a globulin protein found in the blood serum of more complex animals. In the complement system, an innate-immunity series of proenzymes dissolved in the circulation, it is also called "Factor P". It is known that it participates in some specific immune responses. It plays a part in tissue inflammation as well as the engulfing of pathogens by phagocytes. In addition it is known to help to neutralize some viruses.
As a component of the alternative pathway for complement activation (otherwise known as the "properdin pathway"), it complexes with another protein, C3b, to stabilize the alternative C3 convertase (C3bBb) that then cleaves more C3.Properdin was discovered in 1954 by Dr. Louis Pillemer of the Institute of Pathology .

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA783Hu01 Recombinant Complement Factor P (CFP) Positive Control; Immunogen; SDS-PAGE; WB.
RPA783Hu02 Recombinant Complement Factor P (CFP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA783Hu01 Polyclonal Antibody to Complement Factor P (CFP) WB; IHC; ICC; IP; FCM
MAA783Hu22 Monoclonal Antibody to Complement Factor P (CFP) WB; IHC; ICC; IP.
LAA783Hu71 Biotin-Linked Polyclonal Antibody to Complement Factor P (CFP) WB; IHC; ICC.
PAA783Hu02 Polyclonal Antibody to Complement Factor P (CFP) WB; IHC; ICC; IP.
Assay Kits SEA783Hu ELISA Kit for Complement Factor P (CFP) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA783Hu CLIA Kit for Complement Factor P (CFP) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA783Mu01 Recombinant Complement Factor P (CFP) Positive Control; Immunogen; SDS-PAGE; WB.
RPA783Mu02 Recombinant Complement Factor P (CFP) Positive Control; Immunogen; SDS-PAGE; WB.
RPA783Mu03 Recombinant Complement Factor P (CFP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA783Mu01 Polyclonal Antibody to Complement Factor P (CFP) WB; IHC; ICC; IP.
PAA783Mu02 Polyclonal Antibody to Complement Factor P (CFP) WB; IHC; ICC; IP.
LAA783Mu71 Biotin-Linked Polyclonal Antibody to Complement Factor P (CFP) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Complement Factor P (CFP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Complement Factor P (CFP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA783Ra01 Recombinant Complement Factor P (CFP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Complement Factor P (CFP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Complement Factor P (CFP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Complement Factor P (CFP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Complement Factor P (CFP) ELISA Kit Customized Service Offer
  1. "Molecular cloning of the cDNA coding for properdin, a positive regulator of the alternative pathway of human complement."Eur. J. Immunol. 21:771-776(1991) [PubMed] [Europe PMC] [Abstract]
  2. "Characterization of the human properdin gene."Biochem. J. 287:291-297(1992) [PubMed] [Europe PMC] [Abstract]
  3. "Detection of properdin mRNA in human peripheral blood monocytes and spleen."J. Lab. Clin. Med. 120:762-766(1992) [PubMed] [Europe PMC] [Abstract]
  4. "Sequence-based analysis of properdin deficiency: identification of point mutations in two phenotypic forms of an X-linked immunodeficiency."Genomics 29:1-8(1995) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Properdin, the positive regulator of complement, is highly C-mannosylated."J. Biol. Chem. 275:28569-28574(2000) [PubMed] [Europe PMC] [Abstract]
  8. "C-mannosylation and O-fucosylation of thrombospondin type 1 repeats."Mol. Cell. Proteomics 1:11-18(2002) [PubMed] [Europe PMC] [Abstract]
  9. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Native polymeric forms of properdin selectively bind to targets and promote activation of the alternative pathway of complement."Immunobiology 215:932-940(2010) [PubMed] [Europe PMC] [Abstract]
  11. "A strategy for precise and large scale identification of core fucosylated glycoproteins."Mol. Cell. Proteomics 8:913-923(2009) [PubMed] [Europe PMC] [Abstract]
  12. "The dimeric and trimeric solution structures of the multidomain complement protein properdin by X-ray scattering, analytical ultracentrifugation and constrained modelling."J. Mol. Biol. 343:1327-1343(2004) [PubMed] [Europe PMC] [Abstract]
  13. "Molecular characterization of properdin deficiency type III: dysfunction produced by a single point mutation in exon 9 of the structural gene causing a tyrosine to aspartic acid interchange."J. Immunol. 157:3666-3671(1996) [PubMed] [Europe PMC] [Abstract]
  14. "Expression of properdin in complete and incomplete deficiency: normal in vitro synthesis by monocytes in two cases with properdin deficiency type II due to distinct mutations."J. Clin. Immunol. 18:272-282(1998) [PubMed] [Europe PMC] [Abstract]
  15. "Molecular characterisation of 10 Dutch properdin type I deficient families: mutation analysis and X-inactivation studies."Eur. J. Hum. Genet. 8:513-518(2000) [PubMed] [Europe PMC] [Abstract]
  16. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]