Programmed Cell Death Protein 1 Ligand 1 (PDL1)
[Edit]CD274; PDCD1LG1; B7-H; B7H1; PD-L1; PDCD1L1; PDCD1-LG1; Programed Death Ligand 1
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CD274 (Cluster of Differentiation 274) also known as PD-L1 (Programed Death Ligand-1) or B7-H1 is a protein,PD-L1 binds to its receptor, PD-1, found on activated T cells, B cells, and myeloid cells, to modulate activation or inhibition. The affinity between PD-L1 and PD-1, as defined by the dissociation constant Kd, is 770nM. Interestingly, PD-L1 also has an appreciable affinity for the costimulatory molecule CD80 (B7-1), but not CD86 (B7-2).
CD80's affinity for PD-L1, 1.4µM, is intermediate between its affinities for CD28 and CTLA-4 (4.0µM and 400nM, respectively). The related molecule PD-L2 has no such affinity for CD80 or CD86, but shares PD-1 as a receptor (with a stronger Kd of 140nM).
Organism species: Homo sapiens (Human)
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA788Mu01 | Recombinant Programmed Cell Death Protein 1 Ligand 1 (PDL1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPA788Mu02 | Recombinant Programmed Cell Death Protein 1 Ligand 1 (PDL1) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAA788Mu01 | Polyclonal Antibody to Programmed Cell Death Protein 1 Ligand 1 (PDL1) | WB; IHC; ICC; IP. |
| PAA788Mu02 | Polyclonal Antibody to Programmed Cell Death Protein 1 Ligand 1 (PDL1) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA788Mu | ELISA Kit for Programmed Cell Death Protein 1 Ligand 1 (PDL1) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| AEA788Mu | ELISA Kit for Anti-Programmed Cell Death Protein 1 Ligand 1 Antibody (Anti-PDL1) | Enzyme-linked immunosorbent assay for Antibody Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA788Ra01 | Recombinant Programmed Cell Death Protein 1 Ligand 1 (PDL1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA788Ra01 | Polyclonal Antibody to Programmed Cell Death Protein 1 Ligand 1 (PDL1) | WB; IHC; ICC; IP. |
| MAA788Ra21 | Monoclonal Antibody to Programmed Cell Death Protein 1 Ligand 1 (PDL1) | WB; IHC; ICC; IP. | |
| MAA788Ra22 | Monoclonal Antibody to Programmed Cell Death Protein 1 Ligand 1 (PDL1) | WB; IHC; ICC; IP. | |
| MAA788Ra23 | Monoclonal Antibody to Programmed Cell Death Protein 1 Ligand 1 (PDL1) | WB; IHC; ICC; IP. | |
| MAA788Ra24 | Monoclonal Antibody to Programmed Cell Death Protein 1 Ligand 1 (PDL1) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA788Ra | ELISA Kit for Programmed Cell Death Protein 1 Ligand 1 (PDL1) | Enzyme-linked immunosorbent assay for Antigen Detection. |
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